scholarly journals Non-Melanoma Facial Skin Tumors—The Correspondence between Clinical and Histological Diagnosis

2021 ◽  
Vol 11 (16) ◽  
pp. 7543
Author(s):  
Camelia Tamas ◽  
Irina Mihaela Jemnoschi Hreniuc ◽  
Angela Tecuceanu ◽  
Bogdan Mihnea Ciuntu ◽  
Clara Larisa Ibanescu ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Malignant Tumors ◽  
Skin Tumors ◽  
Histological Diagnosis ◽  
Benign Tumors ◽  
Facial Skin ◽  
Correlation Data ◽  
Clinical Differential Diagnosis ◽  
Histological Results

This paper consists of a retrospective study that includes a total of 186 cases with facial skin tumors diagnosed and treated between January 2015 and December 2017. Our aim was to correlate the initial clinical diagnosis with the histological results, in order to observe the success rate of our clinical experience, but also to underline that certain clinical tumor aspects can be misleading as the histological findings can result in different final diagnostics. From the total number of cases, we counted a total of 226 tumors (both benign and malignant), from which 194 had the clinical diagnosis confirmed by the anatomopathological exam and 34 had a different laboratory result from the clinical presumption: 10 benign tumors and 22 malignant tumors (eight BCC and 14 SCC, 12 of the latter being confused with ulcerovegetant BCC). Detailed correlation data were presented, as well as different situations of incongruence between the clinical and the histological diagnosis. The long-term goal of the study was to use our experience of correlating the clinical and the histological diagnosis, in order to improve the existing knowledge on the clinical differential diagnosis of both malignant and benign facial skin tumors.

Retrospective Evaluation of Lingual Tumors in 42 Dogs: 1999–2005

2008 ◽  
Vol 44 (6) ◽  
pp. 308-319 ◽  
Author(s):  
Jason A. Syrcle ◽  
Jennifer J. Bonczynski ◽  
Sebastien Monette ◽  
Philip J. Bergman
Keyword(s):  
Prognostic Factors ◽  
Retrospective Study ◽  
Benign Tumor ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Tumor Type ◽  
Retrospective Evaluation ◽  
Short Term ◽  
Drinking Habits

In this retrospective study of 42 cases of lingual tumors in dogs, 27 (64%) were malignant, and 15 (36%) were benign. Median survival time for dogs with benign tumors was >1607 days, compared to 286 days for malignant tumors. Prognostic factors significantly associated with increased survival included complete histological margins (P=0.036), smaller tumor size (P=0.003), and benign tumor type (P=0.011). Smaller tumors were more likely to be completely resected (P=0.008) and were less likely to recur (P=0.001). Partial or subtotal glossectomies were performed in 13 cases. Short-term morbidity associated with glossectomy included ptyalism and dehiscence. Long-term morbidity included minor changes in eating and drinking habits.

Surgical Treatment of Primary Cardiac Tumors

1997 ◽  
Vol 5 (2) ◽  
pp. 101-103 ◽  
Author(s):  
Gu Chun Jiu ◽  
Bao Wei Ke ◽  
Guo Bin Xun ◽  
Yuan Hong ◽  
Xiu Zhong Yi
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumors ◽  
Right Atrial ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Long Term Result ◽  
The Right ◽  
Medical University ◽  
Primary Cardiac Tumors

During a 16-year period from 1980 to 1996, 101 patients with primary cardiac tumors underwent surgery at the 1st Affiliated Hospital of China Medical University, which represented 2.44% of 4142 open-heart surgical cases during this period. Most tumors were benign; 94 were myxomas, 2 were fibromas, and 1 was a hemangioma. Three myxomas were in the right atrium and 91 were in the left atrium. The 4 malignant tumors comprised 2 mesothelioma, 1 histiocytoma, and 1 right atrial malignant myxoma. All benign tumors were completely excised with 4.95% mortality. Only 1 malignant tumor was completely excised. In our experience, the long-term result of surgical treatment of benign cardiac tumors is excellent, whereas the prognosis for patients with malignant cardiac tumors is very poor. The incidence of malignant tumors was lower than in other studies.

scholarly journals Tumor jinak kulit pada wajah

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Ferra O. Mawu
Keyword(s):  
Skin Surface ◽  
Skin Lesions ◽  
Skin Tumors ◽  
Careful Examination ◽  
Benign Tumors ◽  
Facial Skin ◽  
Skin Tag ◽  
The Face ◽  
Seborrheic Keratoses

Abstract: Benign skin tumors are commonly found in every individual. There are various benign tumors occur on the skin surface including facial skin. The main problems of these tumors are cosmetic concerns and the possibility of malignancy. Benign skin tumors frequently found on the face are inter alia seborrheic keratoses, skin tag, syringoma, nevus pigmentosus, xanthelasma, sebaceous hyperplasia, and cyst. Several benign facial skin lesions can be diagnosed clinically as long as it is supported by careful examination with good anamnesis and proper lighting. Physicians as well as specialists must have the ability to categorize and diagnose accurately the growing lesions or tumors as benign, malignant, or undetermined in order to take further step for planning and providing treatment properly.Keywords: seborrheic wart, skin tag, syringomaAbstrak: Hampir semua orang memiliki satu atau lebih tumor kulit yang pada umumnya adalah tumor jinak. Tumor jinak kulit dapat terjadi di seluruh permukaan kulit termasuk kulit wajah. Tumor kulit pada wajah umumnya menimbulkan masalah kosmetik dan kemungkinan pertumbuhan ke arah keganasan. Tumor jinak pada wajah yang sering ditemukan antara lain ialah keratosis seboroik, skin tag, siringoma, nevus pigmentosus, xantelasma, hiperplasia sebasea, dan kista. Secara klinik beberapa tumor jinak kulit pada wajah dapat langsung terdiagnosis, dengan syarat pemeriksaan dilakukan dengan teliti, mulai dari anamnesa sampai pemeriksaan fisik yang dilakukan di bawah penerangan yang baik. Dokter atau dokter ahli harus mampu mengategorikan tumor kulit sebagai tumor jinak/benigna, ganas/maligna, atau tidak jelas, sehingga kemungkinan penatalaksanaan dapat ditetapkan.Kata kunci: keratosis seboroik, skin tag, siringoma

scholarly journals Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

2021 ◽  
Author(s):  
A. C. Clemens ◽  
K. U. Loeffler ◽  
F. G. Holz ◽  
M. C. Herwig-Carl
Keyword(s):  
Clinical Diagnosis ◽  
Sebaceous Gland ◽  
Malignant Tumors ◽  
Pyogenic Granuloma ◽  
Hair Follicles ◽  
Benign Tumors ◽  
Reactive Lymphoid Hyperplasia ◽  
Histopathological Analysis ◽  
Pathological Correlation ◽  
Malignant Lesions

Abstract Purpose The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians. Methods Retrospective evaluation with clinico-pathologic correlation of surgically removed caruncular tumors between 1998 and 2020 at a tertiary referral center. Results Eighty-two caruncular tumors were identified in the respective period. The patients were between 11 and 85 years of age (mean, 46.8 years; median, 49 years). Nevi (n = 35), cystic lesions (n = 14), oncocytoma (n = 9), papilloma (n = 8), sebaceous gland hyperplasia (n = 8), and reactive lymphoid hyperplasia (n = 4) were observed most frequently. Besides, we are the first reporting herniated orbital fat accompanied by a pyogenic granuloma. 2.4% (n = 2) were malignant tumors (sebaceous gland carcinoma, conjunctival intraepithelial neoplasia with pyogenic granuloma). Conclusion Caruncular tumors show a broad spectrum of mostly benign tumors. They can occur in patients of any age. However, 8/9 oncocytomas and both malignant lesions were detected in patients older than 60 years. Although the clinical diagnosis was confirmed in only 68.3% by the histopathological analysis, the two malignant lesions were identified as such already clinically. Caruncular lesions with a history of growth or other signs of malignancy should be excised followed by detailed histopathological examination to allow a final diagnosis and exclude rare malignant tumors with lethal potential.

Current Concepts in the Management of Tumors of the Skull Base

1998 ◽  
Vol 5 (2) ◽  
pp. 138-149 ◽  
Author(s):  
Akio Morita ◽  
Laligam N. Sekhar ◽  
Donald C. Wright
Keyword(s):  
Skull Base ◽  
Malignant Tumors ◽  
Surgical Techniques ◽  
Surgical Excision ◽  
Cranial Base ◽  
Benign Tumors ◽  
Tumor Control ◽  
High Morbidity ◽  
Fractionated Radiotherapy

Background: Due to their involvement with critical neurovascular structures, tumors located in the cranial base present challenges to neurosurgeons and are associated with high morbidity and mortality. Methods: Rates of tumor control, complications, patient outcomes, and recurrences were extracted and summarized from two decades of our surgical and radiological treatment follow-up and review of the medical literature. Results: Recent advances in surgical techniques involving cranial base approaches have made surgical intervention safer and curative resection more likely. In managing benign tumors, surgical resection is the gold standard for treatment. While immediate complications are still significant, long-term outcomes in most cases are excellent. Focused radiosurgery using a gamma knife or linear accelerator has produced favorable outcomes, and it improves the management of small or minimally symptomatic cranial base tumors. For slow-growing malignant tumors, extensive surgery followed by radiotherapy achieves the best outcome. In managing highly malignant tumors, outcome is determined by the effects of chemotherapy and radiotherapy. On some occasions, surgery is needed to obtain greater control of highly malignant tumors. Conclusions: Skull base tumors are relatively common, and management of these tumors is rapidly evolving. The combination of surgical excision using cranial base techniques, radiosurgery, fractionated radiotherapy, and chemotherapy should be individually tailored based on the location and pathological aggressiveness of the tumor and the symptomatology of the patient. Appreciation is expressed to Jennifer Pryll for her illustrative and photographic assistance and to Joseph Reister for editing and preparing the manuscript.

scholarly journals Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Helen R. Davies ◽  
Kirsty Hodgson ◽  
Edward Schwalbe ◽  
Jonathan Coxhead ◽  
Naomi Sinclair ◽  
...  
Keyword(s):  
Pulmonary Metastases ◽  
Malignant Tumors ◽  
Skin Tumors ◽  
Benign Tumors ◽  
Multigenerational Families ◽  
Epigenetic Modifiers ◽  
Genomic Landscape ◽  
Recurrent Mutations ◽  
Multi Level ◽  
Genomic Methylation

Abstract Patients with CYLD cutaneous syndrome (CCS; syn. Brooke-Spiegler syndrome) carry germline mutations in the tumor suppressor CYLD and develop multiple skin tumors with diverse histophenotypes. Here, we comprehensively profile the genomic landscape of 42 benign and malignant tumors across 13 individuals from four multigenerational families and discover recurrent mutations in epigenetic modifiers DNMT3A and BCOR in 29% of benign tumors. Multi-level and microdissected sampling strikingly reveal that many clones with different DNMT3A mutations exist in these benign tumors, suggesting that intra-tumor heterogeneity is common. Integrated genomic, methylation and transcriptomic profiling in selected tumors suggest that isoform-specific DNMT3A2 mutations are associated with dysregulated methylation. Phylogenetic and mutational signature analyses confirm cylindroma pulmonary metastases from primary skin tumors. These findings contribute to existing paradigms of cutaneous tumorigenesis and metastasis.

Primary Intrathoracic Neurogenic Tumors: Clinical, Pathological, and Long-Term Outcomes

2020 ◽  
Author(s):  
Domenico Galetta ◽  
Lorenzo Spaggiari
Keyword(s):  
Malignant Tumors ◽  
Postoperative Radiotherapy ◽  
Lung Parenchyma ◽  
Posterior Mediastinum ◽  
Invasive Technique ◽  
Benign Tumors ◽  
Thoracic Inlet ◽  
Neurogenic Tumors

Abstract Background Intrathoracic neurogenic tumors (INTs) are uncommon neoplasms arising from nerve tissues. We report our single-center experience in treating these rare INTs. Methods Using a prospective institutional database, clinical, surgical, and pathological records of patients receiving resection of INT between May 1998 and June 2018 were analyzed. Survival was calculated by Kaplan–Meier method. Results There were 82 patients (24 females) with an average age of 53 years (29–75 years). Mean diameter was 32 mm (range, 12–68 mm). Histology included 49 schwannomas (11 malignant), 15 neurinomas (2 malignant), 14 neurilemmomas, and 4 paragangliomas. Tumor was located in the posterior mediastinum in 52 patients, in the thoracic inlet in 12, in the anterior mediastinum in 7, in the lung parenchyma in 5, and in the chest wall in 3. In three (3.6%) patients, the tumor showed an intraspinal extension. Symptoms were reported in 51 patients (62.2%) and included cough in 23, dyspnea in 15, neurologic symptoms in 11, and wheezing in 2. Operation was performed by thoracotomy in 42 (51.2%) cases and less invasive technique in 40 (48.8%) cases. Resection was completed in 80 patients (97.6%). Postoperative radiotherapy was administered in two cases. Intraoperative and postoperative mortalities were nil. Morbidity occurred in four patients (4.8%) including two prolonged air leaks, one hemothorax, and one chylothorax. Five-year survival was 97% (mean follow-up, 4.9 years). Malignant tumors had a worse prognosis (p = 0.02). No recurrence occurred during the follow-up neither for malignant nor for benign tumors. Conclusion The treatment of choice for INTs is complete resection which will be tailored to tumor size, location, and extension. Long-term prognosis is favorable for benign neurogenic tumors.

scholarly journals Clinicopathological Evaluation of Eyelid and Conjunctival Lesions in Patients of Farshchian Hospital in Hamadan

2018 ◽  
Vol 3 (3) ◽  
pp. 120
Author(s):  
Fateme Eslami ◽  
Hamidreza Ghasemibasir
Keyword(s):  
Clinical Diagnosis ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Final Diagnosis ◽  
Histological Diagnosis ◽  
Bulbar Conjunctiva ◽  
Benign Lesions ◽  
Cross Sectional ◽  
Clinical Appearance

Introduction: The lesions of the eyelid and conjunctiva are benign and malignant. The ratio of benign lesions is more than the malignant, increases with age, and are easily diagnosed clinically. However, in some cases, the clinical diagnosis of malignant tumors is impossible, necessitating the final diagnosis by histopathological examination. The incidence of benign and malignant tumors differs between countries according to the genetics of the racial population or environmental factors.Materials and methods: This cross-sectional descriptive study was conducted on 424 patients with eyelid and conjunctival lesions from the Farshchian Hospital of Hamadan between 2010–2014. The final pathological report, clinical diagnosis, demographic variables including age and gender, site of lesions, and clinical appearance were extracted from medical records.Results: The lesions consisted of 159 (37.5%) eyelid and 265 (62.5%) conjunctival lesions. The predominant location was bulbar conjunctiva (35.1%), and the least was external canthus (1.7%). The most frequent lesion based on clinical diagnosis was pterygium (51.7%), and the least frequent was sebaceous glands carcinoma. The most frequent lesion based on histological diagnosis was pterygium (52.5%), and the least frequent was xanthelasma. In this study, the concordance between clinical and histological diagnosis was 90.3% that indicated the physician’s accurate diagnosis.Conclusion: According to this study, the frequency of eyelid and conjunctival lesion was similar in males and females. The prevalence of lesions in >60-year-olds is more common than that in other age groups. The benign lesions of eyelids and conjunctiva are common than malignant lesions. Despite high clinicopathological concordance, the physician should always consider the rare cases, and the pathological diagnosis must be considered for all specimens.

Thermal Simulations of Cancerous Breast Tumors and Cysts on a Realistic Female Torso

2021 ◽  
Author(s):  
Francisco J Gonzalez
Keyword(s):  
Clinical Diagnosis ◽  
Computational Models ◽  
Infrared Imaging ◽  
Malignant Tumors ◽  
Diagnostic Technique ◽  
Breast Tumors ◽  
Benign Tumors ◽  
Temperature Pattern ◽  
Thermal Pattern ◽  
Thermal Simulations

Abstract Thermography as a clinical imaging technique has been around for several decades, however it has not become a common diagnostic technique mainly due to its low specificity. The development of computational models of heat transfer in biological tissue can provide a deeper knowledge of healthy and non-healthy thermal patterns could increase the usefulness of thermography in clinical diagnosis. In this work the thermal pattern of cancerous and benign breast tumors are calculated through finite element computer simulations using a realistic female human torso. The simulation results show a thermal pattern which is consistent with infrared images of female subjects and it is not present in simulations performed using other approximate geometries of the breast. A parametric study using cancerous tumors and cysts as a function of size and depth show that the temperature over the skin closest to the tumor decreases for benign tumors while it increases for malignant tumors, also the temperature patterns show a 20% deviation from thermal simulations using a hemispherical breast model. This result indicates that there is a strong geometric component in the human temperature pattern. These results are a first step to understand benign and malignant thermal processes in the breast which might help increase the usefulness of infrared imaging in breast clinical diagnosis.

scholarly journals Intramuscular myxoma of the thigh: A case report

2020 ◽  
Vol 7 ◽  
Author(s):  
Abderrahim Zaizi ◽  
Hicham Benomar ◽  
Reda Badaoui ◽  
Mohammed Reda Fekhaoui ◽  
Talal Grimi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Intramuscular Myxoma ◽  
Tissue Mass ◽  
Long Term Follow Up ◽  
Short And Long Term ◽  
Magnetic Resonance Imaging Mri

Introduction : Myxomas are rare benign tumors of soft tissue, represent 1% of adult cancers, they are most often located in the intramuscular compartment, particularly in the thigh. They are most often observed in elderly patients between fifth and seventh decade, particularly females.Case report : We present the case of a 60-year-old man with a painless and several years progressive mass of the medial aspect of the left thigh. Magnetic Resonance Imaging (MRI) has showed a tissue mass with cystic lesion. In addition, histopathological diagnosis of the specimen was in favor of an intramuscular myxoma without signs of malignancy. Short and long-term follow-up of two years did not detect any recurrence.Conclusion : The slowly growing character is not an argument of benignity, in contrast to other situations. Therefore, the myxoid component may be present in other soft tissue malignant tumors, specially liposarcoma. This difficulty sometimes imposing more specimen verification or a second opinion. Although myxomas are rare, it is important to keep them in mind when a myxoid component is present and distinguish them from sarcomas.

Sign in / Sign up

Export Citation Format

Share Document