Phytotoxic, clastogenic and bioaccumulation effects of the environmental endocrine disruptor bisphenol A in various crops grown hydroponically

Planta ◽  
2005 ◽  
Vol 223 (5) ◽  
pp. 910-916 ◽  
Author(s):  
Giuseppe Ferrara ◽  
Elisabetta Loffredo ◽  
Nicola Senesi
2021 ◽  
pp. 130287
Author(s):  
Palanisamy Karthika ◽  
Saravanakumar Shanmuganathan ◽  
Subramanian Viswanathan ◽  
Cristina Delerue-Matos

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 780
Author(s):  
Krystyna Makowska ◽  
Slawomir Gonkowski

Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.


2021 ◽  
Vol 552 ◽  
pp. 149513
Author(s):  
A.B. Hernández-Abreu ◽  
S. Álvarez-Torrellas ◽  
R.P. Rocha ◽  
M.F.R. Pereira ◽  
V.I. Águeda ◽  
...  

2021 ◽  
Vol 1150 ◽  
pp. 338228
Author(s):  
P. Arul ◽  
Sheng-Tung Huang ◽  
N.S.K. Gowthaman ◽  
G. Mani ◽  
Nithiya Jeromiyas ◽  
...  

2020 ◽  
Vol 257 ◽  
pp. 113516 ◽  
Author(s):  
Ramin Bahmani ◽  
DongGwan Kim ◽  
Mahsa Modareszadeh ◽  
Andrew J. Thompson ◽  
Jeong Hoon Park ◽  
...  

2012 ◽  
Vol 142 (5) ◽  
pp. S-652
Author(s):  
Sandrine Ménard ◽  
Viorica Braniste ◽  
Mathilde Leveque ◽  
Corinne Lencina ◽  
Manon Naturel ◽  
...  

2007 ◽  
Vol 1 (3) ◽  
pp. 350-356 ◽  
Author(s):  
Bin Xu ◽  
Naiyun Gao ◽  
Min Rui ◽  
Hong Wang ◽  
Haihui Wu

2008 ◽  
Vol 20 (9) ◽  
pp. 75
Author(s):  
C. J. Scott ◽  
I. J. Clarke ◽  
J. Wilkins ◽  
T. Flatscher-Bader ◽  
G. B. Martin ◽  
...  

Bisphenol A (BPA) is an endocrine disruptor, which has both oestrogenic and anti-oestrogenic actions. It has profound effects on development, especially of sex organs but also on the brain. The actions on the brain are poorly understood and little is known about males. Most work has been conducted in fish & rodents, but the lifespan of domestic ruminants means that BPA may accumulate in tissues over many years. This study tested the hypothesis that treatment of ram lambs with BPA would alter LH secretion as well as gene activity in various hypothalamic regions. Ram lambs were treated from 1 month old with thrice weekly injections (im) of BPA (3.5 mg/kg) or vehicle (n = 10/group) for 80days. Weekly bodyweights and jugular blood samples were collected and on day 79, blood samples were taken every 15 min for 8 h for LH RIA. The sheep were killed, body & testicular weights collected and the hypothalamus dissected into anterior, dorsal and ventral blocks, then frozen in liquid nitrogen. Bodyweight (Cont. 26.0 ± 0.5 kg v. BPA 25.2 ± 0.7 kg) and paired testicular weight (Cont. 31.6 ± 1.2 g v. BPA 29.3 ± 1.4 g) did not significantly differ (P > 0.05). LH secretion also did not differ, in either mean LH concentrations (Cont 0.31 ± 0.14 v. BPA 0.29 ± 0.12ng/mL) or pulses/8 h (Cont 1.8 ± 0.4 v. BPA 2.0 ± 0.4). Total RNA was extracted from the basal hypothalamus (ventral block) and RNA from 2 treated and 2 control animals was hybridised on 44K Agilent bovine microarrays. Preliminary analysis suggests 118 probes were differentially expressed. Gene ontology analysis of these differentially expressed probes revealed involvement in a broad range of biological processes and cellular components. This study suggests that gene array analysis is a suitable tool with which to study BPA actions in the sheep hypothalamus. Future work will expand this pilot microarray study to include all animals and all hypothalamic regions.


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