Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma

A total of 401 eligible patients with resected stages B and C colorectal carcinoma were randomly assigned to no-further therapy or to adjuvant treatment with either levamisole alone, 150 mg/d for 3 days every 2 weeks for 1 year, or levamisole plus fluorouracil (5-FU), 450 mg/m2/d intravenously (IV) for 5 days and beginning at 28 days, 450 mg/m2 weekly for 1 year. Levamisole plus 5-FU, and to a lesser extent levamisole alone, reduced cancer recurrence in comparison with no adjuvant therapy. These differences, after correction for imbalances in prognostic variables, were only suggestive for levamisole alone (P = .05) but quite significant for levamisole plus 5-FU (P = .003). Whereas both treatment regimens were associated with overall improvements in survival, these improvements reached borderline significance only for stage C patients treated with levamisole plus 5-FU (P = .03). Therapy was clinically tolerable with either regimen and severe toxicity was uncommon. These promising results have led to a large national intergroup confirmatory trial currently in progress.

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Preoperative prognostic variables and the impact of postoperative adjuvant therapy on the outcomes of stage IB or II cervical carcinoma patients with or without pelvic lymph node metastases

Cancer ◽

10.1002/(sici)1097-0142(19990401)85:7<1537::aid-cncr15>3.0.co;2-6 ◽

1999 ◽

Vol 85 (7) ◽

pp. 1537-1546 ◽

Cited By ~ 91

Author(s):

Chyong-Huey Lai ◽

Ji-Hong Hong ◽

Swei Hsueh ◽

Koon-Kwan Ng ◽

Ting-Chang Chang ◽

...

Keyword(s):

Lymph Node ◽

Adjuvant Therapy ◽

Cervical Carcinoma ◽

Lymph Node Metastases ◽

Pelvic Lymph Node ◽

Postoperative Adjuvant Therapy ◽

Prognostic Variables ◽

Stage Ib ◽

Node Metastases ◽

The Impact

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Primary anatomical site as a prognostic factor for pleomorphic liposarcoma

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-020-03204-y ◽

2020 ◽

Vol 146 (6) ◽

pp. 1501-1508 ◽

Cited By ~ 1

Author(s):

Hea Gie Lee ◽

Sarah Aurit ◽

Peter Silberstein ◽

Jonathan Gootee

Keyword(s):

Prognostic Factor ◽

Anatomical Site ◽

Pleomorphic Liposarcoma ◽

Primary Anatomical Site

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Faculty Opinions recommendation of Primary anatomical site as a prognostic factor for pleomorphic liposarcoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737709016.793581004 ◽

2020 ◽

Author(s):

Richard Riedel

Keyword(s):

Prognostic Factor ◽

Anatomical Site ◽

Pleomorphic Liposarcoma ◽

Primary Anatomical Site

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Primary Site and Other Prognostic Variables Effects on Survival in Pediatric Synovial Sarcoma

Journal of Surgical Oncology ◽

10.31487/j.jso.2019.02.10 ◽

2019 ◽

pp. 1-11

Author(s):

Christina Curtin ◽

Jonathan Gootee ◽

Maria Isabel Gonzaga ◽

Peter Silberstein

Keyword(s):

Soft Tissue ◽

Survival Probability ◽

Tumor Size ◽

Primary Site ◽

Histologic Grade ◽

Survival Outcomes ◽

Anatomical Site ◽

Prognostic Variables ◽

Old Patients ◽

Survival Probabilities

Background: Synovial sarcomas (SS) are an aggressive type of soft tissue sarcoma that represent 10% of soft tissue sarcomas. Patients under the age of 20 represent 30% of all SS, and while pediatric and adult patients with SS have similar clinical presentations, pediatric cases have improved outcomes. Prognostic factors include tumor size, primary site, and presence of distant metastases. Methods: 597 pediatric (<18 years old) patients diagnosed with SS from the National Cancer Database were analyzed. Kaplan-Meier tables were compiled to estimate 1-, 3-, 5-, and 10-year survivals. Groups were compared using log-rank tests and Cox proportional hazards analysis. Results: Median age at diagnosis was 14 years, 79.4% of patients were Caucasian, and median tumor size was 6.0 cm. The most common anatomical primary site was the extremities, specifically the lower limb and hip. Overall 5- and 10-year survival probabilities were 85.3% and 79.5%, respectively. Tumors in the lungs and thorax had the worst survival, with an overall 5-year survival probability of 50.2%, while upper limb and shoulder tumors had the best 5-year survival probability of 95.9%. The 6-10 age range had the best 5- and 10-year survival probabilities and as age increased the overall survival decreased. Pediatric females had better survival outcomes than males. Approximately 91% of pediatric SS did not present with metastases but the most common site of metastasis was the lungs (2.8%). As histologic grade and tumor stage increased, survival decreases, except that stage II disease showed the best 5-year survival. Biphasic histology had better 5- and 10-year survival outcomes when compared to monophasic histology. Conclusion: This is the largest and most comprehensive study on pediatric SS to date. Statistically significant prognostic variables of pediatric SS include primary anatomical site, sex, race, histology type, tumor size, and histologic grade and stage.

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Mutations change excitability and the probability of re-entry in a computational model of cardiac myocytes in the sleeve of the pulmonary vein

10.1101/2021.09.24.461636 ◽

2021 ◽

Author(s):

Karoline Horgmo Jæger ◽

Andrew G. Edwards ◽

Wayne R. Giles ◽

Aslak Tveito

Keyword(s):

Atrial Fibrillation ◽

Finite Element ◽

Computational Model ◽

Cardiac Myocytes ◽

Human Heart ◽

Pulmonary Veins ◽

Anatomical Site ◽

Societal Costs ◽

Ectopic Beats ◽

Primary Anatomical Site

AbstractAtrial fibrillation (AF) is a common health problem with substantial individual and societal costs. The origin of AF has been debated for more than a century, and the precise, biophysical mechanisms that are responsible for the initiation and maintenance of the chaotic electrochemical waves that define AF, remains unclear. It is well accepted that the outlet of the pulmonary veins is the primary anatomical site of AF initiation, and that electrical isolation of these regions remains the most effective treatment for AF. Furthermore, it is well known that certain ion channel or transporter mutations can significantly increase the likelihood of AF. Here, we present a computational model capable of characterizing functionally important features of the microanatomical and electrophysiological substrate that represents the transition from the pulmonary veins (PV) to the left atrium (LA) of the human heart. This model is based on a finite element representation of every myocyte in a segment of this (PV/LA) region. Thus, it allows for investigation a mix of typical PV and LA myocytes. We use the model to investigate the likelihood of ectopic beats and re-entrant waves in a cylindrical geometry representing the transition from PV to LA. In particular, we investigate and illustrate how six different AF- associated mutations can alter the probability of ectopic beats and re-entry in this region.

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