scholarly journals Differential assessment of fluid compartments by bioimpedance in pediatric patients with kidney diseases

2021 ◽  
Author(s):  
Sandra M. Frey ◽  
Bruno Vogt ◽  
Giacomo D. Simonetti ◽  
Rainer Büscher ◽  
Sandra Habbig ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Chronic Kidney Failure ◽  
Whole Body ◽  
Hydration Status ◽  
Control Group ◽  
Fluid Compartment ◽  
Fluid Compartments ◽  
Acute Changes

Abstract Background The kidney is central for maintaining water balance. As a corollary, patients with impaired kidney function are prone to pathological fluid volumes. Total body water (TBW) is distributed between the extracellular (ECW) and intracellular fluid compartments (ICW). In clinical practice, the judgment of hydration status does not allow to distinguish between ECW and ICW. Here, we evaluate the hydration status in children with chronic kidney disease by analyzing TBW, ECW, and ICW. Methods Hydration was quantified using whole-body bioimpedance spectroscopy (BCM) in 128 outpatients (1–25 years, 52 girls). Forty-two were transplanted (TPL), 43 suffered from chronic kidney disease without kidney replacement therapy (CKD), 21 were on peritoneal dialysis (PD), and 22 on hemodialysis (HD). HD patients were investigated before, after, and sequentially during dialysis. Results The ECW and ICW values obtained by BCM were of the same magnitude as those from the literature using isotope dilution. When compared with a healthy control group, TBW was increased in 9 TPL, 9 CKD, 1 PD, and 11 HD patients before but in none after dialysis. The decline of overhydration during dialysis (p < 0.001, n = 22) correlated with the change in body weight (R2 = 0.62). The kinetics of fluid compartment changes assessed twice in six HD patients revealed a reproducible linear decay of the ECW/ICW ratio due to an increase of ICW and a decrease of ECW. Conclusion BCM quantifies TBW and acute changes of ECW and ICW in children with chronic kidney failure. The clinical utility of measuring TBW, ECW, and ICW should be defined in the future.

scholarly journals Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm

2019 ◽  
Author(s):  
Milena Miszczuk ◽  
Verena Müller ◽  
Christian E. Althoff ◽  
Andrea Stroux ◽  
Daniela Widhalm ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Strong Association ◽  
Renal Cysts ◽  
Aortic Aneurysms ◽  
Control Group ◽  
Abdominal Aortic ◽  
And Control ◽  
Charité Berlin

AbstractAbdominal aortic aneurysms (AAA) primarily affect elderly men who often have many other diseases, with similar risk factors and pathobiological mechanisms to AAA. The aim of this study was to assess the prevalence of simple renal cysts (SRC), chronic kidney disease (CKD), and other kidney diseases (e.g. nephrolithiasis) among patients presenting with AAA. Two groups of patients (100/group), with and without AAA, from the Surgical Clinic Charité, Berlin, Germany, were selected for the study. The control group consisted of patients who were evaluated for a kidney donation (n = 14) and patients who were evaluated for an early detection of a melanoma recurrence (n = 86). The AAA and control groups were matched for age and sex. Medical records were analyzed and computed tomography scans were reviewed for the presence of SRC and nephrolithiasis. SRC (73% vs. 57%; p<0.001) and CKD (31% vs. 8%; p<0.001) were both more common among AAA than control group patients. On multivariate analysis, CKD, but not SRC, showed a strong association with AAA. Knowledge about pathobiological mechanisms and association between CKD and AAA could provide better diagnostic and therapeutic approaches for these patients.

scholarly journals Role of interactive survey in early diagnosis of chronic kidney diseases

2021 ◽  
Vol 38 (6) ◽  
pp. 74-82
Author(s):  
Ekaterina Alekseevna Burtseva ◽  
Vitaly Yurievich Mishlanov ◽  
Anna Vladimirovna Anikeeva ◽  
Victoria Ivanovna Selezneva ◽  
Ekaterina Petrovna Koshurnikova ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Early Diagnosis ◽  
Comparative Study ◽  
High Efficiency ◽  
Kidney Diseases ◽  
Kidney Damage ◽  
Control Group ◽  
Low Sensitivity ◽  
Healthy Persons

Objective. To conduct a comparative study of the prevalence of specific symptoms in patients with kidney damage using the automated program "Electronic Polyclinic" to optimize the algorithm for early diagnosis of chronic kidney disease. Materials and methods. 18 patients of the therapeutic unit with kidney lesions, confirmed by laboratory and instrumental studies, as well as 7 healthy persons were examined. The main problems of patients were identified by the method of interactive questioning with the help of the program "Electronic Polyclinic". Further, a statistical analysis of the data and a comparative study with the control group of healthy persons were carried out using STATISTICA 12.0 program. Results. The main symptoms of kidney damage were reliably determined and a low sensitivity of individual symptoms in the diagnosis, in contrast to the syndromic approach, was revealed. It showed that in 100 % of cases the automated program "Electronic Polyclinic" detected the syndromes, that indicates its high efficiency. An algorithm for early diagnosis of chronic kidney disease was proposed, which consists in an initial interactive survey followed by examination formulated by the computer program. Conclusions. The method of interactive survey using the automated program "Electronic Polyclinic" allows you to effectively identify the syndromes of kidney damage, makes a preliminary diagnosis and draws up a plan of examination for further confirmation of the diagnosis. Symptomatic diagnosis has a number of disadvantages including low sensitivity and specificity, so it yields to syndromic diagnosis.

scholarly journals MO809DOES LISTENING TO LIVE MUSIC DURING HEMODIALYSIS SESIONS AFFECT THE QUALITY OF LIFE?*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Miriam Serrano ◽  
Alicia Garcia-Testal ◽  
Inmaculada Rico-Salvador ◽  
Conrado Carrrascosa López ◽  
Rafael Ortiz Ramón ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Classical Music ◽  
Scale Effects ◽  
Kidney Diseases ◽  
Well Being ◽  
Control Group ◽  
Mean Time

Abstract Background and Aims Patients with chronic kidney disease on hemodialysis (HD) treatment have a health-related quality of life (HRQoL) lower than the reference values of the Spanish population. Previous studies have shown through music therapy reduce levels of pain, anxiety and depression in chronic kidney disease patients on hemodialysis. This study presents an intervention with classical music performed live during HD sessions. It is the first time to study the effect of classical music heard live on HRQL. Method Randomized clinical trial by groups. 90 patients agreed to participate. They were randomized into an intervention group (IG) and a control group (CG). The IG listened to 30/45 minutes of live classical music in two of the three weekly HD sessions for 1 month. The CG followed his usual treatment. Different individual scales of the quality of life test in kidney diseases (KDQOL-SF) were analyzed, in two times, baseline (Start) and after (End) the musical intervention in both groups. The analysis was performed using a mixed linear regression model for repeated measures with independent variables (age, sex, months in HD, Kt/v, Hemoglobin (Hb)) and dependent variables (individual KDQOL-SF scale scores). Results The CG sample included 43 patients with a mean age of 75.8 years; 22 women (51%); mean Kt/v 1.53; mean Hb 11.5 and mean time on HD 60.46 months. The GI sample included 47 patients with a mean age of 73.53 years; 18 women (38%); mean Kt/v 1.47; mean Hb 11.3 and mean time on HD 63.34 months. The results show that after the intervention, IG vs CG increased the mean score (pm) in all the scales significantly. The End time and GI interaction showed a mean score increase of 15.78 (p &lt;0.001) for the Symptoms/problems scale; 14.96 (p &lt;0.001) scale Effects of kidney disease; 16.36 (p &lt;0.001) on the Kidney disease burden scale; 14.78 (p &lt;0.001) on the Sleep scale; 25.46 (p &lt;0.001) on the Vitality scale; 29.57 (p &lt;0.001) on the Emotional well-being scale; 41.92 (p &lt;0.001) on the Pain scale and 23.39 (p &lt;0.001) on the General Health scale. Conclusion Live classical music intervention during hemodialysis sessions improves self-perceived HRQL in patients with chronic kidney disease on HD

scholarly journals Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm

2019 ◽  
Author(s):  
Milena Miszczuk ◽  
Verena Müller ◽  
Christian Ernst Althoff ◽  
Andrea Stroux ◽  
Daniela Widhalm ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Strong Association ◽  
Renal Cysts ◽  
Aortic Aneurysms ◽  
Control Group ◽  
Pathophysiological Mechanisms ◽  
Abdominal Aortic ◽  
And Control

Abstract Background: Abdominal aortic aneurysms (AAA) primarily affect men over 65 years old who often have many other diseases, with similar risk factors and pathophysiological mechanisms to AAA. The aim of this study was to assess the prevalence of simple renal cysts (SRC), chronic kidney disease (CKD), and other kidney diseases (e.g. nephrolithiasis) among patients presenting with AAA. Methods: Two groups of patients (100/group), with and without AAA, from the Surgical Clinic Charité, Berlin, Germany, were selected for the study. The control group consisted of patients who were evaluated for a kidney donation (n = 14) and patients who were evaluated for an early detection of a melanoma recurrence (n = 86). The AAA and control groups were matched for age and sex. Medical records were analyzed and computed tomography scans were reviewed for the presence of SRC and nephrolithiasis. Results: SRC (73% vs. 57%; p<0.001) and CKD (31% vs. 8%; p<0.001) were both more common among AAA than control group patients. On multivariate analysis, CKD, but not SRC, showed a strong association with AAA. Conclusions: Knowledge about pathophysiological mechanisms and association between CKD and AAA could provide better diagnostic and therapeutic approaches for these patients.

scholarly journals Features of skin wound healing in rats with experimental chronic kidney disease

2021 ◽  
Vol 12 (4) ◽  
pp. 594-598
Author(s):  
S. B. Pavlov ◽  
O. B. Litvinova ◽  
N. M. Babenko
Keyword(s):  
Chronic Kidney Disease ◽  
Wound Healing ◽  
Growth Factors ◽  
Kidney Disease ◽  
Wound Repair ◽  
Histological Analysis ◽  
Kidney Diseases ◽  
Skin Wound ◽  
Control Group ◽  
Skin Wound Healing

Chronic kidney disease negatively affects the morphofunctional state of all organs due to hemodynamic and metabolic disorders. Changes in the content of cytokines observed in kidney diseases, which regulate the processes of inflammation and tissue repair, can complicate the course of the wound process. This research aimed to study disorders in the process of skin wound repair due to changes in the dynamics of production of interleukins IL-1β, IL-6, IL-10, IL-4, growth factors bFGF and VEGF in animals with experimental chronic kidney disease. The levels of interleukins and growth factors were determined on the 7th, 14th and 28th days after surgical modeling of wounds in the blood of rats with experimental chronic kidney disease and animals of the control group. To assess the dynamics and quality of wound healing, a semi-quantitative histological analysis was performed. The study showed an increase in the content of pro-inflammatory interleukins in the group of sick rats: on the 7th day the level of IL-1β was 1.19 times higher, and IL-6 – 1.55 times, on the 14th day the level of IL-1β was 1.37 times in comparison with the control group. The maximum increase in the concentration of anti-inflammatory interleukins was noted on the 28th day: IL-4 was 2.10 times higher, IL-10 – 1.39 times higher than in the control group. The content of bFGF and VEGF in animals of the control group reached its maximum on the 7th day, and in animals with chronic kidney disease – on the 15th day after surgery. Semi-quantitative histological analysis showed a decrease in indicators in the group of sick animals: the number of fibroblasts and collagen deposition – on the 7th day, reepithelialization – on the 28th day. A persistent increase in the number of polymorphonuclear leukocytes was also noted at all periods of the experiment: by 1.38, 1.99, and 9.82 times – on the 7th, 14th, and 28th days, respectively. The study showed that the dynamics of the production of interleukins and growth factors were impaired in rats with chronic kidney disease. In the process of damage regeneration in sick animals, pro-inflammatory mechanisms prevailed with the involvement of a large number of immunocompetent cells, as a result, skin wounds took longer to heal.

scholarly journals Early screening of chronic kidney disease patients among the asymptomatic adult population in Bangladesh

2020 ◽  
Vol 5 (1) ◽  
pp. e10-e10
Author(s):  
Zebunnesa Zeba ◽  
Kaniz Fatema ◽  
Ahmed Faisal Sumit ◽  
Rahelee Zinnat ◽  
Liaquat Ali
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Large Scale ◽  
Screening Program ◽  
Kidney Diseases ◽  
Demographic Data ◽  
Adult Population ◽  
Control Group ◽  
Asymptomatic Adult

Introduction: Early identification of chronic kidney disease (CKD) provides valuable opportunities for effective interventions that reduce the risk of outcomes, particularly renal failure. Objectives: This study aimed to screen the Bangladeshi asymptomatic adult population for CKD to identify potential risk factors for its development. Patients and Methods: The screening program was carried out among the 400 subjects in the Thakurgaon district of Bangladesh to identify people with the risk of CKD. All the subjects were asymptomatic and previously been never diagnosed with kidney diseases. Demographic data were collected by a structured questionnaire. Urinary protein was tested by dipstick method, and serum creatinine was measured by an auto-analyzer. Estimated glomerular filtration rate (eGFR) was calculated by using standard formula. CKD was diagnosed and classified according to the National Kidney Foundation (NKF) Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. Results: A total of 18.2% respondents were found to have likely CKD to whom 82% were in stage 1 and 18% were in stage 2. The majority of the likely CKD respondents (30.1%) were in age >60 years. The prevalence of proteinuria was significantly (P=0.0001) higher among previously documented CKD patients compared to the control group. Logistic analysis revealed that after adjustments, CKD showed a significant association with diabetes mellitus (ORs: 7.46, P=0.00), smoking (ORs: 2.36, P=0.02), obesity (ORs: 3.98, P=0.00) and hypertension (ORs: 1.16, P=0.66) compared to control. Conclusion: A substantial number of adults were found to be unaware of the existence of CKD hence, large-scale prevention programs should be undertaken to reduce the classical risk factors of these disorders.

scholarly journals Basal Gastric Acid level in Patients of Chronic Kidney Disease

2017 ◽  
Vol 12 (1) ◽  
pp. 10-14
Author(s):  
Nilima Jafrin ◽  
Nayeema Akter ◽  
Shahin Akhter ◽  
Md Myenuddin Mozumder ◽  
Sakhawat Mahmud Khan
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Gastric Acid ◽  
Gastric Juice ◽  
Kidney Diseases ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Ph Level

Background: Gastrointestinal symptoms are common in patients with chronic kidney disease (CKD). Chronic renal failure is associated with an increased incidence of acid-related gastrointestinal disorders.Objective: To determine the pH level of gastric acid in patients of CKD and to correlate the different stages of CKD with gastric acid status.Methods: This study was carried out in the Department of Physiology and Nephrology, Chittagong Medical College and Hospital during January 2008 to December 2008. Total 87 subjects were included in this study, of them 65 patients of diagnosed case of chronic kidney diseases were selected as study group. Age and sex matched 22 apparently healthy persons were selected as control group To assess gastric juice media gastric juice pH level was determined with the help of Model pHs -25 pH meter. Data were analyzed by Chi-square test, Student’s t-test and Pearson’s correlation co-efficient test where applicable.Results: Mean gastric juice pH level of CKD patients was lower than that of control group but it was not statistically significant. Again, pH level of gastric juice was significantly (p<0.001) decreased according to severity of CKD patients. Gradual decrease of pH level was found with the increasing severity of the CKD.Conclusion: In this study gastric juice pH was lowered in patients of chronic kidney disease which was significantly lowered in stage V. So it can be concluded that the gastric acid secretion may increase in chronic renal failure patient.Bangladesh Soc Physiol. 2017, June; 12(1): 10-14

Transient nitric oxide reduction induces permanent cardiac systolic dysfunction and worsens kidney damage in rats with chronic kidney disease

2010 ◽  
Vol 298 (3) ◽  
pp. R815-R823 ◽  
Author(s):  
L. G. Bongartz ◽  
B. Braam ◽  
M. C. Verhaar ◽  
M. J. Cramer ◽  
R. Goldschmeding ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Whole Body ◽  
Control Group ◽  
High Dose ◽  
No Production

Left ventricular systolic dysfunction (LVSD) in patients with chronic kidney disease (CKD) is associated with poorer prognosis. Because patients with CKD often exhibit progressively decreased nitric oxide (NO) availability and inhibition of NO production can reduce cardiac output, we hypothesized that loss of NO availability in CKD contributes to pathogenesis of LVSD. Subtotally nephrectomized (SNX) rats were treated with a low dose of the NO synthase inhibitor Nω-nitro-l-arginine (l-NNA; 20 mg/l water; SNX+l-NNA) and compared with relevant control groups. To study permanent changes separate from hemodynamic effects, l-NNA was stopped after week 8 and rats were followed up to week 15, until blood pressure was similar in SNX+l-NNA and SNX groups. To study effects of NO depletion alone, a control group with high-dose l-NNA (l-NNA-High: 100 mg/l) was included. Mild systolic dysfunction developed at week 13 after SNX. In SNX+l-NNA, systolic function decreased by almost 50% already from week 4 onward, together with markedly reduced whole body NO production and high mortality. In l-NNA-High, LVSD was not as severe as in SNX+l-NNA, and renal function was not affected. Both LVSD and NO depletion were reversible in l-NNA-High after l-NNA was stopped, but both were persistently low in SNX+l-NNA. Proteinuria increased compared with rats with SNX, and glomerulosclerosis and cardiac fibrosis were worsened. We conclude that SNX+l-NNA induced accelerated and permanent LVSD that was functionally and structurally different from CKD or NO depletion alone. Availability of NO appears to play a pivotal role in maintaining cardiac function in CKD.

scholarly journals STUDY ON THE FREQUENCY OF TEETH BRUSHING FOR PATIENTS WITH TERMINAL STAGE OF CHRONIC KIDNEY DISEASE AND BEING ON CHRONIODIALYSIS, AND HEALTHY CONTROLS

2020 ◽  
Vol 26 (4) ◽  
pp. 3481-3484
Author(s):  
Anna Nenova-Nogalcheva ◽  
◽  
Desislava Konstantinova ◽  
Petia Pechalova ◽  
◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Demographic Data ◽  
Control Group ◽  
Healthy Controls ◽  
Terminal Stage ◽  
The People ◽  
Significant Difference ◽  
Main Factor

Dentists usually recommend at least two minutes of brushing two times per day as a minimum. The purpose of this study is to establish the frequency of teeth brushing for patients with terminal stage of chronic kidney disease and for healthy controls. Materials and methods: 140 patients from Northeastern Bulgaria took informed participation, volunteering, in this study. They are separated into two groups – 70 people were diagnosed with terminal stage of chronic kidney disease (CKD) and chroniohemodialysis at different stages of disease duration and 70 healthy controls. Anamnestic and socio-demographic data were collected, about gender, age and frequency of teeth brushing. The result was statistically processed using the IBM SPSS Statistics software, Version 20. Results: Data show that there is a statistically significant difference (χ2 = 79,031, p=0,000 ) between the patients of the groups studied. As we have expected, the patients from the control group brush their teeth more often (between 2 and 3 times per day). The Mann-Whitney test with Bonferroni correction shows that the CKD patients brush their teeth daily less than the people from the control group. Statistically significant difference (U = 1831,000, р = 0,004) is established between the two group participants. Conclusion: The frequency of teeth brushing as a main factor for maintaining good personal oral hygiene is higher for the healthy controls in comparison to the patients under the study, who belong to the group of people with CKD. We need more studies in order to understand better how could the frequency of teeth brushing influence the limitation of oral problems for people with kidney diseases on chroniodialysis.

Stroke in chronic renal failure

2008 ◽  
Vol 149 (15) ◽  
pp. 691-696
Author(s):  
Dániel Bereczki
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Chronic Renal Disease ◽  
Kidney Diseases ◽  
Cerebrovascular Diseases ◽  
Lipid Lowering ◽  
Increased Risk ◽  
Intracerebral Hemorrhages

Chronic kidney diseases and cardiovascular diseases have several common risk factors like hypertension and diabetes. In chronic renal disease stroke risk is several times higher than in the average population. The combination of classical risk factors and those characteristic of chronic kidney disease might explain this increased risk. Among acute cerebrovascular diseases intracerebral hemorrhages are more frequent than in those with normal kidney function. The outcome of stroke is worse in chronic kidney disease. The treatment of stroke (thrombolysis, antiplatelet and anticoagulant treatment, statins, etc.) is an area of clinical research in this patient group. There are no reliable data on the application of thrombolysis in acute stroke in patients with chronic renal disease. Aspirin might be administered. Carefulness, individual considerations and lower doses might be appropriate when using other treatments. The condition of the kidney as well as other associated diseases should be considered during administration of antihypertensive and lipid lowering medications.

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