scholarly journals The Role of FeTi Addition to Micro-inclusions in the Production of ULC Steel Grades via the RH Process Route

2019 ◽  
Vol 164 (11) ◽  
pp. 475-478 ◽  
Author(s):  
Christian Bernhard ◽  
Philipp Dorrer ◽  
Susanne Michelic ◽  
Roman Rössler
Keyword(s):  
Large Population ◽  
Casting Process ◽  
Steel Sample ◽  
Rh Process ◽  
Process Route ◽  
Alumina Particles ◽  
Initial Oxygen ◽  
Steel Grades ◽  
Plant Data

Abstract In the production of ULC steel grades via the RH process route, Al is added first for deoxidation after the end of decarburization and FeTi follows after a certain period of separation of alumina particles and the related reduction of the total oxygen content. The FeTi addition is well known to cause clogging problems in the following casting process. The analysis of plant data by voestalpine Stahl in Linz indicates an increasing clogging tendency with a higher Ti/Al ratio in the steel. Automated SEM/EDS investigations on lollipop samples show the existence of a newly nucleated Ti-containing alumina particle population after the FeTi addition. These particles are comparably smaller than the alumina particles and, even if thermodynamically unstable, they still exist as a large population of small particles in samples taken from the tundish. The addition of Al and FeTi into a molten steel sample with controlled initial oxygen activity for varying Ti/Al ratios was simulated in laboratory scale afterwards. Just like in the plant, a new population of small Ti-containing alumina particles nucleates, with the size and number depending on the Ti/Al ratio in the melt. Laboratory experiments and plant observations are in consistence with each other and indicate—for the underlying process route and process parameters—some countermeasures for the better control of clogging.

scholarly journals Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 723
Author(s):  
Gustavo Cernera ◽  
Marika Comegna ◽  
Monica Gelzo ◽  
Marcella Savoia ◽  
Dario Bruzzese ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Causes Of Death ◽  
Southern Italy ◽  
Large Population ◽  
Mthfr C677t ◽  
Geographic Area ◽  
Gene Variants ◽  
Interesting Possibility ◽  
Ischemic Attack

Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention.

Intergenerational Transmission of Violence Among Substance-Abusing Chinese Parents: Roles of Detachment and Social Support

2021 ◽  
pp. 088626052110374
Author(s):  
Ruixin Cao ◽  
Hechun Li ◽  
Huiping Zhang
Keyword(s):  
Social Support ◽  
Child Abuse ◽  
Childhood Abuse ◽  
Intergenerational Transmission ◽  
Parenting Practices ◽  
Large Population ◽  
Substance Abusing ◽  
Abuse History ◽  
Intergenerational Transmission Of Violence

Despite a large population of registered people with drug addiction, child protection in substance-abusing families is a neglected issue in China. The present study aims to investigate the association between parents’ childhood abuse history and the risk of abusing their own children in substance-abusing Chinese families and also to examine the mediating role of detachment and moderating role of social support during the intergenerational transmission of abuse. A total of 173 men and 116 women were selected using cluster sampling from two compulsory drug rehabilitation centers in Jiangsu Province. Results indicated that one’s childhood abuse history was positively associated with the current perpetration of child abuse for both fathers and mothers. Detachment mediated the linkage between a history of childhood maltreatment and perpetration of child abuse in all types of abuse for both men and women except for women’s sexual abuse. Social support from family members buffered the intergenerational transmission of child abuse for fathers but not for mothers. Child maltreatment in substance-abusing families is an urgent issue that needs measures to prevent the intergenerational transmission of violence in China. Intervention programs could involve helping parents cope with their childhood abuse history through rebuilding secure attachment and facilitating social support for their parenting practices, especially for fathers.

Assessing the Unacquainted: Inferred Reviewer Personality and Review Helpfulness

MIS Quarterly ◽  
2021 ◽  
Vol 45 (3) ◽  
pp. 1113-1148
Author(s):  
Angela Xia Liu ◽  
◽  
Yilin Li ◽  
Sean Xu ◽  
◽  
...  
Keyword(s):  
Personality Traits ◽  
Supervised Classification ◽  
Large Population ◽  
Superior Performance ◽  
Product Reviews ◽  
Review Helpfulness ◽  
Personality Theories ◽  
Deep Learning Model ◽  
Practical Implications

This work examines the question of who is more likely to provide future helpful reviews in the context of online product reviews by synergistically using personality theories and data analytics. It trains a deep learning model to infer a reviewer’s personality traits. This enables analyses to reveal the role of personality traits in review helpfulness among a large population of reviewers. We develop hypotheses on how personality traits are associated with review helpfulness, followed by hypotheses testing that confirms that higher review helpfulness is related to higher openness, conscientiousness, extraversion, and agreeableness and to lower emotional stability. These results suggest the appropriateness of using these five personality traits as inputs for developing a model for predicting future review helpfulness. Based on an ensemble model using supervised classification algorithms, we develop a predictive model and demonstrate its superior performance. Theoretical and practical implications are discussed.

The role of vacuum degree in the bonding of Al/Mg bimetal prepared by a compound casting process

2019 ◽  
Vol 265 ◽  
pp. 112-121 ◽  
Author(s):  
Guangyu Li ◽  
Wenchao Yang ◽  
Wenming Jiang ◽  
Feng Guan ◽  
Haixiao Jiang ◽  
...  
Keyword(s):  
Casting Process ◽  
Vacuum Degree ◽  
Compound Casting ◽  
Compound Casting Process

scholarly journals Ancestry of the AUTS2 family–A novel group of polycomb-complex proteins involved in human neurological disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0232101
Author(s):  
Robert A. Sellers ◽  
David L. Robertson ◽  
May Tassabehji
Keyword(s):  
Autosomal Dominant ◽  
Large Population ◽  
Evolutionary Analysis ◽  
Genome Data ◽  
High Prevalence ◽  
And Function ◽  
Polycomb Complex ◽  
Putative Domain ◽  
Human Specific

Autism susceptibility candidate 2 (AUTS2) is a neurodevelopmental regulator associated with an autosomal dominant intellectual disability syndrome, AUTS2 syndrome, and is implicated as an important gene in human-specific evolution. AUTS2 exists as part of a tripartite gene family, the AUTS2 family, which includes two relatively undefined proteins, Fibrosin (FBRS) and Fibrosin-like protein 1 (FBRSL1). Evolutionary ancestors of AUTS2 have not been formally identified outside of the Animalia clade. A Drosophila melanogaster protein, Tay bridge, with a role in neurodevelopment, has been shown to display limited similarity to the C-terminal of AUTS2, suggesting that evolutionary ancestors of the AUTS2 family may exist within other Protostome lineages. Here we present an evolutionary analysis of the AUTS2 family, which highlights ancestral homologs of AUTS2 in multiple Protostome species, implicates AUTS2 as the closest human relative to the progenitor of the AUTS2 family, and demonstrates that Tay bridge is a divergent ortholog of the ancestral AUTS2 progenitor gene. We also define regions of high relative sequence identity, with potential functional significance, shared by the extended AUTS2 protein family. Using structural predictions coupled with sequence conservation and human variant data from 15,708 individuals, a putative domain structure for AUTS2 was produced that can be used to aid interpretation of the consequences of nucleotide variation on protein structure and function in human disease. To assess the role of AUTS2 in human-specific evolution, we recalculated allele frequencies at previously identified human derived sites using large population genome data, and show a high prevalence of ancestral alleles, suggesting that AUTS2 may not be a rapidly evolving gene, as previously thought.

scholarly journals Genetic Analysis of Neuroligin 4Y Gene in Autism Population of India

2021 ◽  
Author(s):  
Rajat Hegde ◽  
Smita Hegde ◽  
Suyamindra S. Kulkarni ◽  
Aditya Pandurangi ◽  
Pramod B. Gai ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Genetic Analysis ◽  
Missense Mutation ◽  
Mentally Ill ◽  
Large Population ◽  
Original Structure ◽  
Male Predominance ◽  
Local Configuration ◽  
Autistic Population

Abstract Background Autism is one of the most complex, heterogeneous neurological disorders. It is characterized mainly by abnormal communication, impaired social interaction, and restricted behaviors. Prevalence of autism is not clear in Indian population. Aim The present study hypothesizes that Y chromosome plays role in sex bias of autism in Indian autistic population. To investigate our hypothesis, we underwent genetic analysis of neuroligin 4Y [NLGN4Y] gene by sequencing 85 male autistic children after screening large population of 1,870 mentally ill children from North Karnataka region of India. Result Detailed sequencing of the single targeted gene revealed nine variants including, one novel missense mutation and eight synonymous variants; this accounts for 88.9% of synonymous variants. A single novel missense mutation is predicted to be nonpathogenic on the functions of neuroligin4Y protein but it slightly affects the local configuration by altering the original structure of a protein by changing charge and size of amino acid. Conclusion Probably NLGN4Y gene may not be the risk factor for autism in male children in Indian autistic population. Functional analysis was an important limitation of our study. Therefore, detailed functional analysis is necessary to determine the exact role of novel missense mutation of neuroligin 4Y [NLGN4Y] gene especially in the male predominance of autism in Indian autistic population.

The Dynamics of the Global Value Chains and Disruptive Technologies

2021 ◽  
pp. 203-217
Author(s):  
Michael Oluwaseun Olomu
Keyword(s):  
Large Population ◽  
Spillover Effect ◽  
Global Value Chains ◽  
Value Chains ◽  
Competitive Advantages ◽  
African Countries ◽  
Disruptive Technologies ◽  
Conceptual Shift ◽  
Innovation Practices

The advents of GVCs and disruptive technologies have provided alternative paths to industrialization and economic development for African countries, and with the transformation to digitalization now well under way, another conceptual shift is required to understand the evolving role of disruptive technologies in GVCs. It is evident that technological breakthroughs in the global markets have a spillover effect in the structural settings of African economies value chains, as lower tariffs and rapid technological changes have fragmented production across borders, but some African countries remain marginalized in GVCs. This study, therefore, attempts to preliminarily explain how African economies and markets capture value from disruptive technologies and create their competitive advantages within the global value chains context from the perspective of business-model innovation practices in African markets. Thus, developing African firms should not ignore those disruptive growth opportunities within the large population of mass customers and non-consumers in emerging economies.

Are ICT/Web 2.0 Tools Influencing Civic Engagement in Modern Democracies?

2012 ◽  
Vol 4 (4) ◽  
pp. 70-85
Author(s):  
Indu Nair ◽  
Bardo Fraunholz ◽  
Chandana Unnithan
Keyword(s):  
Public Opinion ◽  
Civic Engagement ◽  
Web 2.0 ◽  
Large Population ◽  
Electoral System ◽  
Democratic Governance ◽  
Central Theme ◽  
Web 2.0 Tools ◽  
Indian Context

Web 2.0 tools, while mobilising citizens to make informed choices, may also manipulated public opinion. This hypothesis forms the central theme of this research investigation through the historiography lens. Based on concurrent research from decade, the authors take a closer look at citizen-to-citizen engagement, so as to trace the role of web 2.0 tools, in perhaps manipulating public opinion or enabling democratic governance through reversal of some existing defects in the Indian context. Specifically, they raise these questions: Has ICT enabled civic engagement manipulated public opinion in this developing democracy? Has it succeeded in reversing apparent defects in the electoral system, which is regarded pivotal in democracies? Focusing on the elections, the authors present a synopsis of the use of web 2.0 tools which were seemingly efficiently and prolifically used during the elections albeit to reach out to the large population base in this country.

scholarly journals Patterns and Determinants of Complementary and Alternative Medicine Practitioner Use among Adults with Diabetes in Queensland, Australia

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Chi-Wai Lui ◽  
Jo Dower ◽  
Maria Donald ◽  
Joseph R. Coll
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Care Service ◽  
Health Care Service ◽  
Large Population ◽  
Significant Difference ◽  
Complementary And Alternative

There is evidence that complementary and alternative medicine (CAM) use is common among people with diabetes. The role of CAM in the treatment or management of diabetes is an emerging health issue given the potential side effects and benefits associated with the use of this kind of medicine. This paper examined patterns and determinants of CAM practitioner use in Queensland, Australia, using a large population-based sample of people with type 1 and type 2 diabetes. The study found that within a 12-month period, 7.7% of people with diabetes used the services of CAM practitioners alongside or as a complement to conventional health care service. Younger age, female gender, a higher education, having private health insurance, and engagement in preventive health behaviours are significant predictors of individuals who are more likely to visit a CAM practitioner. There was no significant difference in CAM practitioner use between people with type 1, type 2 insulin requiring, or type 2 noninsulin requiring diabetes. The findings highlight the need for further research on the role of CAM in the prevention and management of diabetes.

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