Colorimetric and electrochemical (dual) thrombin assay based on the use of a platinum nanoparticle modified metal-organic framework (type Fe-MIL-88) acting as a peroxidase mimic

2019 ◽  
Vol 186 (2) ◽  
Author(s):  
Ting Cheng ◽  
Xiang Li ◽  
Peng Huang ◽  
Han Wang ◽  
Meixia Wang ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Peroxidase Mimic ◽  
Platinum Nanoparticle ◽  
Metal Organic ◽  
Organic Framework

A nanosized metal–organic framework of Fe-MIL-88NH2 as a novel peroxidase mimic used for colorimetric detection of glucose

The Analyst ◽  
2013 ◽  
Vol 138 (16) ◽  
pp. 4526 ◽  
Author(s):  
Ya Li Liu ◽  
Xi Juan Zhao ◽  
Xiao Xi Yang ◽  
Yuan Fang Li
Keyword(s):  
Metal Organic Framework ◽  
Colorimetric Detection ◽  
Peroxidase Mimic ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Stable DNA Aptamer–Metal–Organic Framework as Horseradish Peroxidase Mimic for Ultra-Sensitive Detection of Carcinoembryonic Antigen in Serum

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 181
Author(s):  
Lingjun Sha ◽  
Mingcong Zhu ◽  
Fuqing Lin ◽  
Xiaomeng Yu ◽  
Langjian Dong ◽  
...  
Keyword(s):  
Horseradish Peroxidase ◽  
Carcinoembryonic Antigen ◽  
Limit Of Detection ◽  
Detection System ◽  
Metal Organic Framework ◽  
Dna Aptamer ◽  
Sensitive Detection ◽  
Peroxidase Mimic ◽  
Metal Organic ◽  
Organic Framework

Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. For CEA detection, a novel type of metal–organic framework (MOF) was prepared by grafting CEA aptamer-incorporated DNA tetrahedral (TDN) nanostructures into PCN-222 (Fe)-based MOF (referred as CEAapt-TDN-MOF colloid nanorods). The synthesized CEAapt-TDN-MOF is a very stable detection system due to the vertex phosphorylated TDN structure at the interface, possessing a one-year shelf-life. Moreover, it exhibits a significant horseradish peroxidase mimicking activity due to the iron porphyrin ring, which leads to a colorimetric reaction upon binding toward antibody-captured CEA. Using this method, we successfully achieved the highly specific and ultra-sensitive detection of CEA with a limit of detection as low as 3.3 pg/mL. In addition, this method can detect and analyze the target proteins in clinical serum samples, effectively identify the difference between normal individuals and patients with colon cancer, and provide a new method for the clinical diagnosis of tumors, demonstrating a great application potential.

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