scholarly journals Voltammetric sensor based on long alkyl chain tetraalkylammonium ionic liquids comprising ascorbate anion for determination of nitrite

2021 ◽  
Vol 188 (2) ◽  
Author(s):  
Tomasz Rębiś ◽  
Michał Niemczak ◽  
Patrycja Płócienniczak ◽  
Juliusz Pernak ◽  
Grzegorz Milczarek
Keyword(s):  
Ionic Liquids ◽  
Electrostatic Interactions ◽  
Film Surface ◽  
Modified Electrodes ◽  
Voltammetric Sensor ◽  
Nitrite Oxidation ◽  
Alkyl Chains ◽  
Modified Surface ◽  
Influence Of Ph

AbstractAn electrochemical sensor was fabricated utilizing ionic liquids possessing cations with long alkyl chains such as trimethyl octadecylammonium and behenyl trimethylammonium and ascorbate anion. The ionic liquids were drop-coated onto the electrode. Thin modifying layers were prepared. Cyclic voltammetric investigations revealed electrostatic interactions between the electrochemical probes and the modified surface, proving that a positive charge was established at the film surface. Hence, negatively charged species such as nitrite can be pre-concentrated on the surface of presented modified electrodes. The fabricated electrodes have been used as a voltammetric sensor for nitrite. Due to the electrostatic accumulation properties of long alkyl cation, the assay exhibits a remarkable improvement in the voltammetric response toward nitrite oxidation. The influence of pH on the electrode response was thoroughly investigated, and the mechanism of the electrode was established. The developed sensor showed a linear electrochemical response in the range 1.0–50 μM with a detection limit of 0.1 μM. The electrode revealed good storage stability, reproducibility, and anti-interference ability. The determination of nitrite performed in curing salts brought satisfactory results. Graphical abstract

A Voltammetric Sensor for Simultaneous Determination of Vitamin C and Vitamin B6 in Food Samples Using ZrO2 Nanoparticle/Ionic Liquids Carbon Paste Electrode

2014 ◽  
Vol 8 (3) ◽  
pp. 549-557 ◽  
Author(s):  
Amin Baghizadeh ◽  
Hassan Karimi-Maleh ◽  
Zahra Khoshnama ◽  
Asadollah Hassankhani ◽  
Maryam Abbasghorbani
Keyword(s):  
Ionic Liquids ◽  
Vitamin C ◽  
Simultaneous Determination ◽  
Carbon Paste Electrode ◽  
Vitamin B6 ◽  
Food Samples ◽  
Voltammetric Sensor ◽  
Carbon Paste ◽  
Paste Electrode

Liquid phase determination of adrenaline uses a voltammetric sensor employing CuFe2O4 nanoparticles and room temperature ionic liquids

2016 ◽  
Vol 213 ◽  
pp. 369-373 ◽  
Author(s):  
Razie Bavandpour ◽  
Hassan Karimi-Maleh ◽  
Mohammad Asif ◽  
Vinod Kumar Gupta ◽  
Necip Atar ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Liquid Phase ◽  
Room Temperature ◽  
Room Temperature Ionic Liquids ◽  
Voltammetric Sensor ◽  
Phase Determination

scholarly journals Experimental Design to Enhance Dopamine Electrochemical Detection Using Carbon Paste Electrodes

2021 ◽  
Vol 8 (32) ◽  
pp. 178-197
Author(s):  
Soraya Blum ◽  
Felipe Zahrebelnei ◽  
Noemi Nagata ◽  
Valtencir Zucolotto ◽  
Luiz Mattoso ◽  
...  
Keyword(s):  
Carbon Black ◽  
Modified Electrodes ◽  
Electrochemical Sensing ◽  
Current Response ◽  
Carbon Paste ◽  
Fast Determination ◽  
Intrinsically Conducting Polymers ◽  
Influence Of Ph ◽  
Central Composite

Efforts have been made on the development of new modified electrodes to be used in the fast determination of neurotransmitters, either in commercial drugs or in biological samples. Determination of dopamine (DA), for example, is of great importance since the lack of this neurotransmitter is related to many neurological disorders, including Parkinson’s and Alzheimer’s diseases. In this paper, we present a detailed electrochemical characterization, as well as DA detection studies of paste electrodes incorporating carbon materials in different allotropic forms, including carbon black modified with intrinsically conducting polymers (Eeonomers®), pristine carbon black, graphite, and carbon nanotubes. Emphasis is put on the smaller particle size and larger specific surface area of CB Eeonomers® materials, which led to an improved electroanalytical performance for the developed devices. The electrodes fabricated with Eeonomers® modified with polyaniline exhibited the higher current response towards DA detection, in addition to the ability of distinguishing DA from its natural interferent, ascorbic acid. Furthermore, a central composite design was used to investigate the influence of pH and electrode composition (proportion of Eeonomers®) on the electrochemical sensing of DA. A greater sensitivity was achieved for 50:50 (w/w) KP20/KPy20 electrode at pH 7.0. The optimized devices showed to be promising tools to perform quick, cheap and sensitive detection of this neurotransmitter in bioanalytical systems.

Dispersive Liquid-Liquid Microextraction Based on Ionic Liquid and Spectrophotometric Determination of Bilirubin in Biological Samples

2020 ◽  
Vol 16 (5) ◽  
pp. 652-659
Author(s):  
Asiye A. Avan ◽  
Hayati Filik
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Biological Samples ◽  
Urine Samples ◽  
Spectrophotometric Detection ◽  
Full Color ◽  
Dispersive Liquid Liquid Microextraction ◽  
Urine And Serum ◽  
Liquid Microextraction

Background: An Ionic Liquid-based based Dispersive Liquid-Liquid Microextraction (IL-DLLME) method was not applied to preconcentration and determination of bilirubin. Ionic Liquids (ILs) are new chemical compounds. In recent years, Ionic Liquids (ILs) have been employed as alternative solvents to toxic organic solvents. Due to these perfect properties, ILs have already been applied in many analytical extraction processes, presenting high extraction yield and selectivity for analytes. Methods: In this study, IL-DLLME was applied to biological samples (urine and serum) for the spectrophotometric detection of bilirubin. For bilirubin analysis, the full-color development was based on the reaction with periodate in the presence of hydrochloric acid. The high affinity of bilirubin for the ionic liquid phase gave extraction percentages above 98% in 0.3 M HCl solution. Results: Several IL-extraction parameters were optimized and room temperature ionic liquid 1-butyl- 1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide and ethanol were used as extraction and disperser solution. The linear range was found in the range of 0.5-6.0 μM (0.3-3.5 μg mL-1) and the limits of detection of the proposed method was 0.5 μM (0.3 μg mL-1). The proposed method was applied for the preconcentration and separation of trace bilirubin in real urine samples. Also, the recoveries for bilirubin in spiked biological samples (urine and serum) were found to be acceptable, between 95-102%. Conclusion: The proposed IL-DLLMEapproach was employed for the enrichment and determination of trace levels of bilirubin in urine samples using NaIO4 as an oxidizing agent and Uv-vis spectrophotometric detection. The periodate oxidation of bilirubin is rapid, effective, selective, and simple to perform. The method contains only HCl, NaOI4, and an anionic surfactant. The method may be useful for economizing in the consumption of reagents in bilirubin determining. The IL-DLLMEmethod ensures a high yield and has a low toxicity no skin sensitization, no mutagenicity and no ecotoxicity in an aquatic environment since only very low quantities of an IL is required. For full-color formation, no any extra auxiliary reagents are required. Besides, the IL-DLLME technique uses a low-cost instrument such as Uv-vis which is present in most of the medical laboratories.

A Review of Voltammetric Methods for Determination of Dopamine Agonists

2020 ◽  
Vol 16 ◽  
Author(s):  
Fatma Ağin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biological Samples ◽  
Dopamine Agonists ◽  
Modified Electrodes ◽  
Nerve Cells ◽  
Electroanalytical Methods ◽  
Voltammetry Methods ◽  
Voltammetric Methods

Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early stages and in later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. The voltammetry is one of the most commonly used electroanalytical methods. The aims of this review are to gather and discuss studies of voltammetric methods used in determination of dopamine agonists. Method: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters. Results: Cabergoline, pramipexole, ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and lineer sweep voltammetry methods are less applied methods. In this studies, a lot of modified electrodes were developed and used to analyse of dopamine agonists. Conclusion: The voltammetric methods supply determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.

Electroanalysis of Tricyclic Psychotropic Drugs using Modified Electrodes

2019 ◽  
Vol 15 (4) ◽  
pp. 423-442 ◽  
Author(s):  
Mona Habibi-Kool-Gheshlaghi ◽  
Farnoush Faridbod ◽  
Mahya Karami Mosammam ◽  
Mohammad Reza Ganjali
Keyword(s):  
Psychotropic Drugs ◽  
Analytical Methods ◽  
Electrochemical Techniques ◽  
Modified Electrodes ◽  
Electroanalytical Methods ◽  
Drug Assays ◽  
Medical Importance ◽  
Tricyclic Rings ◽  
Easy Operation

Background: Tricyclic psychotropic drugs are defined as a tricyclic rings of the dibenzazepine group with the presence of sulfur and nitrogen atoms. They have been prescribed for antidepressive therapy over the years. Due to their medical importance, many analytical methods have been developed for their monitoring. However, benefits of electrochemical techniques such as costeffectiveness, fast, easy operation and non-destructiveness make them appropriate analytical methods for drug assays. Electrochemical determinations of pharmaceuticals require suitable working electrodes. During years, many electrodes are modified by a variety of modifiers and several sensors were developed based on them. In this regard, nanomaterials, due to their remarkable properties, are one of the most important choices. Objective: Here, the application of electroanalytical methods in the determination of electroactive tricyclic psychotropic drugs will be reviewed and the nanomaterials which are used for improvements of the working electrodes will be considered.

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