Effect of crude microbial enzyme pretreatment on the liberation of biological compounds and antioxidant activity of red ginseng extract

2013 ◽  
Vol 22 (3) ◽  
pp. 729-737
Author(s):  
Wei-Jie Wu ◽  
Byung-Yong Ahn
Keyword(s):  
Antioxidant Activity ◽  
Red Ginseng ◽  
Ginseng Extract ◽  
Enzyme Pretreatment ◽  
Microbial Enzyme ◽  
Biological Compounds

Effect of Red Ginseng Extract on Storage and Antioxidant Activity of Tofu

2008 ◽  
Vol 37 (11) ◽  
pp. 1497-1506 ◽  
Author(s):  
Jung-Suk Lee ◽  
Gyo-Nam Kim ◽  
Hae-Dong Jang
Keyword(s):  
Antioxidant Activity ◽  
Red Ginseng ◽  
Ginseng Extract

scholarly journals Improved Hygroscopicity and Bioavailability of Solid Dispersion of Red Ginseng Extract with Silicon Dioxide

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1022
Author(s):  
Sojeong Jin ◽  
Chul Haeng Lee ◽  
Dong Yu Lim ◽  
Jaehyeok Lee ◽  
Soo-Jin Park ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Intestinal Permeability ◽  
Solid Dispersion ◽  
Ussing Chamber ◽  
Red Ginseng ◽  
Scanning Calorimetry ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Powder Formulation ◽  
Significant Difference

This study aims to develop a powder formulation for the Korean red ginseng extract (RGE) and to evaluate its in vitro and in vivo formulation characteristics. The solid dispersion of RGE was prepared with hydrophilic carriers using a freeze-drying method. After conducting the water sorption–desorption isothermogram (relative humidity between 30 and 70% RH), differential scanning calorimetry thermal behavior, dissolution test, and intestinal permeation study, a solid dispersion formulation of RGE and silicon dioxide (RGE-SiO2) was selected. RGE-SiO2 formulation increased intestinal permeability of ginsenoside Rb1 (GRb1), GRb2, GRc, and GRd by 1.6-fold in rat jejunal segments as measured by the Ussing chamber system. A 1.6- to 1.8-fold increase in plasma exposure of GRb1, GRb2, GRc, and GRd in rats was observed following oral administration of RGE-SiO2 (375 mg/kg as RGE). No significant difference was observed in the time to reach maximum concentration (Tmax) and half-life in comparison to those in RGE administered rats (375 mg/kg). In conclusion, formulating solid dispersion of RGE with amorphous SiO2, the powder formulation of RGE was successfully formulated with improved hygroscopicity, increased intestinal permeability, and enhanced oral bioavailability and is therefore suitable for processing solid formulations of RGE product.

scholarly journals Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-κB and ERK1/2 pathways in colon cancer

2018 ◽  
Vol 42 (3) ◽  
pp. 288-297 ◽  
Author(s):  
Eui Joo Kim ◽  
Kwang An Kwon ◽  
Young Eun Lee ◽  
Ju Hyun Kim ◽  
Se-Hee Kim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Mesenchymal Transition

scholarly journals Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ann-Yae Na ◽  
Jung Jae Jo ◽  
Oh Kwang Kwon ◽  
Piljoung Cho ◽  
Yan Gao ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Herbal Remedy ◽  
Chronic Administration ◽  
Serum Glucose ◽  
Control Group ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Glucose Levels ◽  
Term Administration

AbstractGinseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (H2S) synthesis in the liver. This investigation provides novel evidence that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver.

scholarly journals Alterations of Spontaneous Sleep Architecture and Cortical Electroencephalogram Power Spectra by Red Ginseng Extract via GABAAergic Systems

2010 ◽  
Vol 34 (4) ◽  
pp. 304-313 ◽  
Author(s):  
Shu-Long Yang ◽  
Sang-Yoon Nam ◽  
Jin-Yi Han ◽  
Jun-Cheol Kim ◽  
Ki-Nam Lee ◽  
...  
Keyword(s):  
Power Spectra ◽  
Sleep Architecture ◽  
Red Ginseng ◽  
Ginseng Extract
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