scholarly journals Activity of anti-CR3-RP polyclonal antibody against biofilms formed by Candida auris, a multidrug-resistant emerging fungal pathogen

2018 ◽  
Vol 38 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Jaroslava Dekkerová ◽  
Jose L. Lopez-Ribot ◽  
Helena Bujdáková
Keyword(s):  
Polyclonal Antibody ◽  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris

scholarly journals Hog1 signalling in the emerging multidrug resistant fungal pathogen Candida auris

2019 ◽  
Vol 1 (9) ◽  
Author(s):  
Leon Bamborough ◽  
Janet Quinn ◽  
Alison Day
Keyword(s):  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris

Relative Resistance of the Emerging Fungal Pathogen Candida auris and Other Candida Species to Killing by Ultraviolet Light

2017 ◽  
Vol 39 (1) ◽  
pp. 94-96 ◽  
Author(s):  
Jennifer L. Cadnum ◽  
Aaron A. Shaikh ◽  
Christina T. Piedrahita ◽  
Annette L. Jencson ◽  
Emily L. Larkin ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Species ◽  
Fungal Pathogen ◽  
Laboratory Testing ◽  
Multidrug Resistant ◽  
Relative Resistance ◽  
Candida Auris ◽  
Healthcare Facilities ◽  
Ultraviolet C ◽  
Uv C

Mobile ultraviolet-C (UV-C) light room decontamination devices are frequently used as an adjunct to standard cleaning in healthcare facilities, but their efficacy in killing Candida species is not clear. In laboratory testing, the emerging multidrug-resistant Candida auris and 2 other Candida species were significantly less susceptible to killing by UV-C than methicillin-resistant Staphylococcus aureus.Infect Control Hosp Epidemiol 2018;39:94–96

scholarly journals Assessment of Environmental and Occupational Exposure while Working with Candida auris a Multidrug Resistant (MDR) Fungus in the Animal Facility.

2018 ◽  
Author(s):  
Steven R. Torres ◽  
Heather C. Kim ◽  
Lynn Leach ◽  
Sudha Chaturvedi ◽  
Corey J. Bennett ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Animal Models ◽  
Fungal Pathogen ◽  
Small Animal ◽  
Multidrug Resistant ◽  
Murine Models ◽  
Candida Auris ◽  
Buddy System ◽  
Small Animal Models ◽  
Dose Dependent

In less than a decade since its identification in 2009, the emerging fungal pathogen Candida auris has become a major public health threat due to its multidrug resistant (MDR) phenotype, high transmissibility, and high mortality. Unlike any other Candida species, C. auris has acquired high levels of resistance to an already limited arsenal of antifungals. As an emerging pathogen, there are currently a limited number of documented murine models of C. auris infection. These animal models use inoculums as high as 107-108 cells per mouse, and the environmental and occupational exposure of working with these models has not been clearly defined. Using an intravenous model of C. auris infection, this study determined that shedding of the organism is dose-dependent. C. auris was detected in the cage bedding when mice were infected with 107 and 108 cells, but not with doses of 105 and 106 cells. Potential for exposure to C. auris during necropsies and when working with infected tissues was also demonstrated. To mitigate these potential exposures, a rigorous buddy system workflow, biomonitoring and disinfection procedures were developed that can be used to prevent accidental exposures when using small animal models of C. auris infection.

scholarly journals A Markerless CRISPR-Mediated System for Genome Editing in Candida auris Reveals a Conserved Role for Cas5 in the Caspofungin Response

2021 ◽  
Author(s):  
Craig L. Ennis ◽  
Aaron D. Hernday ◽  
Clarissa J. Nobile
Keyword(s):  
Genome Editing ◽  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Content Type ◽  
Life Threatening ◽  
Systemic Infections

Candida auris is a recently emerged multidrug-resistant fungal pathogen capable of causing life-threatening systemic infections in humans. Few tools are available for genome editing in C. auris .

scholarly journals Candida auris: A Review of Recommendations for Detection and Control in Healthcare Settings

2019 ◽  
Vol 5 (4) ◽  
pp. 111 ◽  
Author(s):  
Diego H. Caceres ◽  
Kaitlin Forsberg ◽  
Rory M. Welsh ◽  
David Joseph Sexton ◽  
Shawn R. Lockhart ◽  
...  
Keyword(s):  
Early Detection ◽  
Infection Control ◽  
High Mortality ◽  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Laboratory Methods ◽  
Healthcare Settings ◽  
The World ◽  
And Control

Candida auris is an emerging multidrug-resistant fungal pathogen. Since first reported in 2009, C. auris has caused healthcare outbreaks around the world, often involving high mortality. Identification of C. auris has been a major challenge as many common conventional laboratory methods cannot accurately detect it. Early detection and implementation of infection control practices can prevent its spread. The aim of this review is to describe recommendations for the detection and control of C. auris in healthcare settings.

scholarly journals Candida auris: The recent emergence of a multidrug-resistant fungal pathogen

2018 ◽  
Vol 57 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Kaitlin Forsberg ◽  
Kate Woodworth ◽  
Maroya Walters ◽  
Elizabeth L Berkow ◽  
Brendan Jackson ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Recent Emergence

scholarly journals Erratum: Candida auris: The recent emergence of a multidrug-resistant fungal Pathogen

2019 ◽  
Vol 57 (4) ◽  
pp. e7-e7 ◽  
Author(s):  
Kaitlin Forsberg ◽  
Kate Woodworth ◽  
Maroya Walters ◽  
Elizabeth L Berkow ◽  
Brendan Jackson ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Recent Emergence

scholarly journals Candida auris: an Emerging Fungal Pathogen

2017 ◽  
Vol 56 (2) ◽  
Author(s):  
Emily S. Spivak ◽  
Kimberly E. Hanson
Keyword(s):  
Health Care ◽  
Fungal Pathogen ◽  
Multidrug Resistant ◽  
Health Care Facilities ◽  
Candida Auris ◽  
Environmental Persistence ◽  
Content Type ◽  
Antifungal Drug Resistance ◽  
Hospital Infection Control ◽  
Skin Colonization

ABSTRACT Candida auris has emerged globally as a multidrug-resistant health care-associated fungal pathogen. Recent reports highlight ongoing challenges due to organism misidentification, high rates of antifungal drug resistance, and significant patient mortality. The predilection for transmission within and between health care facilities possibly promoted by virulence factors that facilitate skin colonization and environmental persistence is unique among Candida species. This minireview details the global emergence of C. auris and discusses issues relevant to clinical microbiology laboratories, hospital infection control, and antimicrobial stewardship efforts.

scholarly journals Environmental Surfaces in Healthcare Facilities are a Potential Source for Transmission ofCandida aurisand OtherCandidaSpecies

2017 ◽  
Vol 38 (9) ◽  
pp. 1107-1109 ◽  
Author(s):  
Christina T. Piedrahita ◽  
Jennifer L. Cadnum ◽  
Annette L. Jencson ◽  
Aaron A. Shaikh ◽  
Mahmoud A. Ghannoum ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Laboratory Testing ◽  
Multidrug Resistant ◽  
Infect Control Hosp ◽  
Hospital Environment ◽  
Candida Auris ◽  
Healthcare Facilities ◽  
Potential Source ◽  
Environmental Surfaces

Contaminated surfaces have been implicated as a potential route for dissemination of the emerging multidrug-resistant fungal pathogenCandida auris. In laboratory testing,C. aurisand otherCandidaspecies persisted for 7 days on moist or dry surfaces.Candidaspecies were recovered frequently from the hospital environment, particularly from moist surfaces.Infect Control Hosp Epidemiol2017;38:1107–1109

scholarly journals Experimental Mouse Models of Disseminated Candida auris Infection

mSphere ◽  
2019 ◽  
Vol 4 (5) ◽  
Author(s):  
Hong Xin ◽  
Farhan Mohiuddin ◽  
Jensen Tran ◽  
Abby Adams ◽  
Karen Eberle
Keyword(s):  
Mouse Model ◽  
Fungal Pathogen ◽  
The United States ◽  
Multidrug Resistant ◽  
Host Responses ◽  
High Dose ◽  
Invasive Infection ◽  
Global Public Health ◽  
Candida Auris ◽  
Content Type

ABSTRACT Disseminated candidiasis is a life-threatening disease and remains the most common bloodstream infection in hospitalized patients in the United States. Despite the availability of modern antifungal therapy, crude mortality in the last decade has remained unacceptably high. In particular, Candida auris is a multidrug-resistant, health care-associated fungal pathogen and has recently emerged as the first fungal pathogen to cause a global public health threat. A reliable animal model for disseminated C. auris candidiasis is therefore needed to study the unique aspects of this little-known host-pathogen interaction. In this study, we established an inbred A/J intravenous model as an appropriate model for human disseminated C. auris infection. We found that C5 deficiency in A/J mice results in a complex phenotype characterized by rapid fungal proliferation in target organs and the development of a unique and rapidly fatal response. In contrast, C57BL/6J mice and mice deficient in neutrophil elastase (NE−/−) survived high-dose C. auris intravenous challenge, even with cyclophosphamide (CY)-induced immunosuppression. Our study is the first to provide insight into the role of C5 in the host responses to C. auris invasive infection and establishes an inbred A/J mouse model of systemic C. auris infection without CY-induced immunosuppression. IMPORTANCE In the last decade, Candida auris has emerged globally as a multidrug‐resistant fungal pathogen. Although C. auris was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing challenges due to organism misidentification, high rates of multifungal drug resistance, and unacceptably high patient mortality. The assessment of C. auris virulence in a specific genetic deficiency mouse model of invasive C. auris infection in this study contributes to the little knowledge of host defense to C. auris infection, which holds promise as a model for investigating the pathogenesis of C. auris invasive infection, exploring the immune responses elicited by the fungus, evaluating the possible induction of immunity to the infection, and targeting candidates for an antifungal vaccine.

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