Quantitative Morphometry of Elastic Fibers in Pelvic Organ Prolapse

2021 ◽  
Author(s):  
Shataakshi Dahal ◽  
Mei Kuang ◽  
Anna Rietsch ◽  
R. S. Butler ◽  
Anand Ramamurthi ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Elastic Fibers ◽  
Quantitative Morphometry

scholarly journals Effect of vaginal distention on elastic fiber synthesis and matrix degradation in the vaginal wall: potential role in the pathogenesis of pelvic organ prolapse

2008 ◽  
Vol 295 (4) ◽  
pp. R1351-R1358 ◽  
Author(s):  
D. D. Rahn ◽  
J. F. Acevedo ◽  
R. A. Word
Keyword(s):  
Pelvic Organ Prolapse ◽  
Protease Activity ◽  
Potential Role ◽  
Elastic Fiber ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Elastic Fibers ◽  
Wild Type ◽  
Fiber Assembly ◽  
Pregnant Mice

Matrix metalloprotease (MMP) activity is increased in the postpartum vagina of wild-type (WT) animals. This degradative activity is also accompanied by a burst in elastic fiber synthesis and assembly. The mechanisms that precipitate these changes are unclear. The goals of this study were to determine how vaginal distention (such as in parturition) affects elastic fiber homeostasis in the vaginal wall and the potential significance of these changes in the pathogenesis of pelvic organ prolapse. Vaginal distention with a balloon simulating parturition resulted in increased MMP-2 and MMP-9 activity in the vaginal wall of nonpregnant and pregnant animals. This was accompanied by visible fragmented and disrupted elastic fibers in the vaginal wall. In nonpregnant animals, the abundant amounts of tropoelastin and fibulin-5 in the vagina were not increased further by distention. In contrast, in pregnant animals, the suppressed levels of both proteins were increased 3-fold after vaginal distention. Distention performed in fibulin-5-deficient ( Fbln5−/−) mice with defective elastic fiber synthesis and assembly induced accelerated pelvic organ prolapse, which never recovered. We conclude that, in pregnant mice, vaginal distention results in increased protease activity in the vaginal wall but also increased synthesis of proteins important for elastic fiber assembly. Distention may thereby contribute to the burst of elastic fiber synthesis in the postpartum vagina. The finding that distention results in accelerated pelvic organ prolapse in Fbln5−/− animals, but not in WT, indicates that elastic fiber synthesis is crucial for recovery of the vaginal wall from distention-induced increases in vaginal protease activity.

scholarly journals Profile of Matrix Metalloproteinase Activity, Markers of Collagen and Elastin Degradation and Remodeling During Pregnancy, Delivery, and Puerperium in Pelvic Organ Prolapse 3 Months After Childbirth

2021 ◽  
Author(s):  
Tyas Priyatini ◽  
Budi Iman Santoso ◽  
Trika Irianta ◽  
Herqutanto . ◽  
Nuryati Chairani Siregar ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Matrix Metalloproteinase ◽  
Blood Sample ◽  
Post Partum ◽  
Pelvic Organ ◽  
Elastic Fibers ◽  
Type I ◽  
Fiber Assembly ◽  
Procollagen Type ◽  
Significant Difference

Abstract Introduction: Pelvic organ prolapse (POP) is a common condition that negatively impacts the quality of life of millions of women. Recent results indicate that a burst of elastic fiber assembly and cross-linking occurs in the vaginal wall postpartum and that synthesis and assembly of elastic fibers are crucial for the recovery of pelvic organ support after vaginal delivery.Methods: A total of 39 primigravida women with gestational age > 36 weeks who underwent vaginal delivery were included in this study. Blood and urine samples were taken for laboratory assessment including carboxyl-terminal telopeptide of the type I collagen (ICTP), procollagen type I N-propeptide (PINP), procollagen type-III N-propeptide (PIIINP), desmosine, tropoelastin, and matrix metalloproteinase-9 (MMP-9). At 24 ˗ 48 hours after labor, the subject was observed in the treatment room and a second blood sample was taken for the examination. At 6 weeks post-partum, a third blood sample was taken for examination.Results: There was a significant relationship between serum MMP-9 levels six weeks post-partum in the pelvic floor dysfunction group and the control group (p = 0.025). In addition, a significant difference was also found in the different levels of MMP-9 (p = 0.041) and tropoelastin (p = 0.041) during delivery and 6 weeks after delivery. There was a significant difference between serum ICTP levels at delivery in the cystocele and control groups (p = 0.042), ICTP (p = 0.019) and tropoelastin (p = 0.046) levels also differ significantly during delivery and 6 weeks after delivery.Conclusion: ICTP, MMP-9, and tropoelastin are potential biomarkers in association with pelvic organ prolapse.

V478: POP-Q Based Staging and Outcomes of Robotic Abdominal Sacrocolpopexy for Advanced Pelvic Organ Prolapse

2007 ◽  
Vol 177 (4S) ◽  
pp. 160-160
Author(s):  
Sarah E. McAchran ◽  
John C. Kefer ◽  
Courtenay Moore ◽  
Jihad H. Kaouk ◽  
Firouz Daneshgari
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Advanced Pelvic Organ Prolapse ◽  
Abdominal Sacrocolpopexy

HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Pelvic Organ Prolapse ◽  
Case Control Study ◽  
Pelvic Organ ◽  
Case Control ◽  
T Test ◽  
Pelvic Organ Prolapse Quantification ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

Experience of conservative treatment of genital prolapse with urogynecological pessaries

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 24-26
Author(s):  
Gennady Y Yarin ◽  
Inna A Vilgelmi ◽  
Evgeny V Liuft
Keyword(s):  
Patient Satisfaction ◽  
Pelvic Organ Prolapse ◽  
Conservative Treatment ◽  
Genital Prolapse ◽  
Treatment Method ◽  
Pelvic Organ ◽  
Safety And Efficacy ◽  
Treatment Methods ◽  
Complications Rate

Background. Pelvic organ prolapse is one of the most common women's diseases worldwide. Genital prolapse incidence among women over 50 is on average 41%. There are variety methods for genital prolapse treatment; they are divided into surgical and non-surgical ones. One of the conservative treatment methods is a use of pessaries. According to different studies an efficacy of pessary therapy is approximately 60%. Aim to estimate a safety and efficacy of genital prolapse conservative treatment with a cube pessary on the basis on standardized questionnaires. Outcomes and methods. In ANO “NRITO Clinic” Urology and Gynecology Center 26 women with various degree genital prolapse were treated with pessary within the period from August 2015 to March 2016. Efficacy of pessaries use, patient satisfaction with this treatment method and complications rate were estimated. Results. Urogynecological cube pessary use in a treatment of various types of genital prolapse is quite an effective method (p

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