Association between Disturbances in Polyunsaturated Fatty Acid Metabolism and Development of Oxidative Stress during Experimental Diabetes Mellitus

2019 ◽  
Vol 167 (3) ◽  
pp. 343-346
Author(s):  
N. P. Mikaelyan ◽  
A. S. Dvornikov ◽  
A. A. Mikaelyan ◽  
N. V. Smirnova
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus

scholarly journals THE ALTERATION OF COMPOSITION OF FATTY ACIDS AND INSULIN-BINDING ACTIVITY OF CELLS IN CONDITIONS OF OXIDATIVE STRESS UNDER EXPERIMENTAL DIABETES MELLITUS

2017 ◽  
Vol 23 (6) ◽  
pp. 308-311
Author(s):  
Nina P. Mikaelyan ◽  
A. E Gurina ◽  
A. A Terentev ◽  
A. A Mikaelyan
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Unsaturated Fatty Acids ◽  
Experimental Diabetes ◽  
Saturated Fatty Acids ◽  
Insulin Binding ◽  
Binding Activity ◽  
Experimental Diabetes Mellitus

The parallel study of effect of experimental diabetes mellitus on the level of lipids and composition of fatty acids in blood and homogenates of liver and insulin-binding activity of cells in conditions of oxidative stress demonstrated that in rats already at early period of development of diabetes, alongside with hyperlipoproteinemia, hypertriglyceridemia and hypercholesterolemia significant alterations are marked in structure of fatty acids and homogenates of liver. These alterations are accompanied by peroxide oxidation of lipids and decreasing of activity of enzymes-antioxidants and also by decreasing of insulin-binding activity of cells. Under experimental diabetes mellitus, a significant increasing of level of saturated fatty acids, especially palmitic fatty acid results in decreasing of levels of mono-unsaturated fatty acids (at the expense of oleic fatty acid) that significantly differs corresponding specter in patients with diabetes. The increasing of concentration of eicosapentaenoic and docosahexaenoic acids is accompanied by decreasing of total content of fatty acid Omega-3 at the expense of alfa-linoleic fatty acid. At that, the level of fatty acid Omega-6 reliably decreases both in erythrocytes and homogenates of liver. The results of study also testify that already at early stages of development of diabetes mellitus alterations in pool of fatty acids of erythrocytes and homogenates of liver are similar (with slight differences) and in all analyzed tissues disorder of metabolism of fatty acids has an anti-sclerotic direction.

scholarly journals Delta-6-desaturase Links Polyunsaturated Fatty Acid Metabolism With Phospholipid Remodeling and Disease Progression in Heart Failure

2014 ◽  
Vol 7 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Catherine H. Le ◽  
Christopher M. Mulligan ◽  
Melissa A. Routh ◽  
Gerrit J. Bouma ◽  
Melinda A. Frye ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acid ◽  
Disease Progression ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Delta 6 Desaturase

Polyunsaturated fatty acid metabolism in enterocyte models: T84 cell line vs. Caco-2 cell line

2013 ◽  
Vol 50 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Pauline Beguin ◽  
Anne-Catherine Schneider ◽  
Eric Mignolet ◽  
Yves-Jacques Schneider ◽  
Yvan Larondelle
Keyword(s):  
Fatty Acid ◽  
Cell Line ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
T84 Cell Line

scholarly journals Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

2018 ◽  
Vol 22 (7) ◽  
pp. 3388-3396 ◽  
Author(s):  
Rong Huang ◽  
Xinli Xue ◽  
Shengxian Li ◽  
Yuying Wang ◽  
Yun Sun ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polycystic Ovary Syndrome ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Polyunsaturated Fatty Acid Metabolism during Lactation

2000 ◽  
pp. 184-189 ◽  
Author(s):  
H. Demmelmair ◽  
T. Sauerwald ◽  
N. Fidler ◽  
M. Baumheuer ◽  
B. Koletzko
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism

scholarly journals Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sara Huerta-Yepez ◽  
Ana Tirado-Rodriguez ◽  
Mayra R. Montecillo-Aguado ◽  
Jun Yang ◽  
Bruce D. Hammock ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Tumor Progression ◽  
Aryl Hydrocarbon Receptor ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Omega 3 ◽  
Aryl Hydrocarbon ◽  
Omega 6
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