Protection of osteoblastic cells from freeze/thaw cycle-induced oxidative stress by green tea polyphenol

2005 ◽  
Vol 27 (9) ◽  
pp. 655-660 ◽  
Author(s):  
Dong-Wook Han ◽  
Hak Hee Kim ◽  
Mi Hee Lee ◽  
Hyun Sook Baek ◽  
Kwon-Yong Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Osteoblastic Cells ◽  
Tea Polyphenol ◽  
Freeze Thaw ◽  
Thaw Cycle ◽  
Green Tea Polyphenol ◽  
Freeze Thaw Cycle

Green tea polyphenol epigallocatechin-3-gallate improves the antioxidant capacity of eggs

2020 ◽  
Vol 11 (1) ◽  
pp. 534-543 ◽  
Author(s):  
Jianping Wang ◽  
Ru Jia ◽  
Pietro Celi ◽  
Xuemei Ding ◽  
Shiping Bai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Antioxidant Capacity ◽  
Green Tea ◽  
Dietary Supplementation ◽  
Tea Polyphenol ◽  
Chemical Substances ◽  
Green Tea Polyphenol

Dietary supplementation with EGCG led to an increase in egg antioxidant activity and antioxidant chemical substances, tryptophan and carotenoid. This may be associated with its increasing effect on the oxidative stress related regulators expression (P38MAPK, Nrf2 and HO-1).

scholarly journals Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Takako Yokozawa ◽  
Jeong Sook Noh ◽  
Chan Hum Park
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Green Tea ◽  
Renal Damage ◽  
Large Fraction ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol ◽  
Low Toxicity

Green tea, prepared from the leaves ofCamellia sinensisL., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (−)-epigallocatechin 3-O-gallate and (−)-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.

scholarly journals The green tea polyphenol EGCG is differentially associated with telomeric regulation in normal human fibroblasts versus cancer cells

2021 ◽  
Vol 11 (3) ◽  
pp. 73
Author(s):  
Angelika Pointner ◽  
Christine Mölzer ◽  
Ulrich Magnet ◽  
Katja Zappe ◽  
Berit Hippe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Green Tea ◽  
Epigenetic Regulation ◽  
Human Fibroblasts ◽  
Methylation Status ◽  
Epigallocatechin Gallate ◽  
Telomerase Activity ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol

Introduction: Topical investigations have demonstrated that oxidative stress and inflammation play key roles in biological aging and determine incidence and course of age-related diseases. Lifestyle and environmental factors hugely impact epigenetic regulation and DNA stability with telomere attrition and epigenetic instability providing a potential record of the cumulative burden of endogenous and exogenous oxidative noxae. Certain physiologically active plant components exhibit antioxidative activities affecting epigenetic regulation of inflammation response and DNA repair.Methods: Against this background, the present study investigated green tea polyphenol epigallocatechin gallate (EGCG) in the context of telomere regulation in Caco-2 colorectal adenocarcinoma cells vs. ES-1 primary skin fibroblasts. Cell lines were treated with 20 and 200 µM EGCG for 36, 72 and 144 hours, respectively. Telomerase activity, relative telomere length as well as methylation status of hTERT and c-Myc from different culture conditions were assessed. Malondialdehyde (MDA) served as a surrogate marker of potential pro-oxidative effects of EGCG in a physiologically relevant tissue model.Results: EGCG incubation was associated with telomere shortening and decreased telomerase activity in Caco-2 cells, and relatively longer telomeres along with increased methylation of six 5'—C—phosphate—G—3' (CpG) sites in the promoter region of human Telomerase Reverse Transcriptase (hTERT) in fibroblasts. At low concentrations, EGCG significantly decreased oxidative damage to lipids in Caco-2 cells and attenuated H2O2 induced oxidation at higher concentrations.Conclusion: These results suggest differential EGCG-mediated telomeric modulation in cancer vs. primary cells and a specific antioxidant activity of EGCG against oxidative damage to lipids in abnormal cells.Keywords: Caco-2, epigallocatechin gallate, telomeres, hTERT, DNA methylation, telomerase, oxidative stress, malondialdehyde

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