Aspects of dietary carbohydrate intake are not related to risk of colorectal polyps in the Tennessee Colorectal Polyp Study

BACKGROUND: Colorectal cancer is a major cause of morbidity and mortality and can arise through the adenoma-carcinoma sequence. Colonoscopy is considered the method of choice for population-wide cancer screening. AIM: To assess the characteristics of endoscopically resected polyps in a consecutive series of patients who underwent colonoscopy at a university hospital and compare histopathology findings according to patient age and polyp size. METHODS: Retrospective, cross-sectional of 1950 colonoscopy reports from consecutively examined patients. The sample was restricted to reports that mentioned colorectal polyps. A chart review was carried out for collection of demographic data and histopathology results. Data were compared for polyps sized ≤0.5 cm and ≥0.6 cm and then for polyps sized ≤1.0 cm and ≥1.1 cm. Finally, all polyps resected from patients aged 49 years or younger were compared with those resected from patients aged 50 years or older. RESULTS: A total of 272 colorectal polyps were resected in 224 of the 1950 colonoscopies included in the sample (11.5%). Polyps >1 cm tended to be pedunculated (p=0.000) and were more likely to exhibit an adenomatous component (p=0.001), a villous component (p=0.000), and dysplasia (p=0.003). These findings held true when the size cutoff was set at 0.5 cm. Patients aged 50 years or older were more likely to have sessile polyps (p=0.023) and polyps located in the proximal colon (p=0.009). There were no significant differences between groups in histopathology or presence of dysplasia. CONCLUSION: Polyp size is associated with presence of adenomas, a villous component, and dysplasia, whereas patient age is more frequently associated with sessile polyps in the proximal colon.

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Dietary carbohydrate intake and mortality: reflections and reactions

The Lancet Public Health ◽

10.1016/s2468-2667(18)30204-4 ◽

2018 ◽

Vol 3 (11) ◽

pp. e516

Author(s):

Marc F Bellemare ◽

Amelia B Finaret

Keyword(s):

Carbohydrate Intake ◽

Dietary Carbohydrate

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Performance of computed tomographic colonography for the screening of colorectal polyp in acromegalic patients: a prospective study

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032009000200003 ◽

2009 ◽

Vol 46 (2) ◽

pp. 90-96 ◽

Cited By ~ 5

Author(s):

Odery Ramos Jr. ◽

César Luiz Boguszewski ◽

Sandra Teixeira ◽

Ricardo De Bem ◽

Benito Parolim ◽

...

Keyword(s):

Prospective Study ◽

Virtual Colonoscopy ◽

Colorectal Polyp ◽

Colorectal Polyps ◽

High Risk Group ◽

Conventional Colonoscopy ◽

Intestinal Loop ◽

Computed Tomographic Colonography ◽

Computed Tomographic ◽

A Prospective Study

CONTEXT: Acromegalic patients have better chances to develop colorectal polyps and cancer and, considered a high-risk group, need to undergo frequent screening examinations. Moreover, in acromegalia, the increased bowel length and the intestinal loop complexity can lead to higher levels of technical difficulties and increase the risks of complications at conventional colonoscopy. Computed tomographic colonography, also known as virtual colonoscopy, is an innovative and secure technology which is revolutionizing the diagnosis of colon and rectum neoplasias. OBJECTIVE: To analyze computed tomographic colonography performance for the screening of colorectal polyps in acromegalic patients. METHODS: A prospective study of 21 asymptomatic acromegalic patients, 12 male and 9 female, average age 49, who underwent computed tomographic colonography and conventional colonoscopy. Computed tomographic colonography was performed with a GE Helical Multislice Computed Tomography Apparatus. Conventional colonoscopy was performed in the same day, without previous knowledge of the computed tomographic colonography diagnostics. The study evaluated the capacity of computed tomographic colonography to detect patients with colorectal polyps and identify each colorectal lesion described by the colonoscopy. RESULTS: In two patients (2/21), conventional colonoscopy was incomplete. However, in all patients computed tomographic colonography was complete. In Phase I ("per patient"), computed tomographic colonography diagnosed eight of the nine patients with colorectal polyps and showed 88% sensitivity, 75% specificity and 81% accuracy. In Phase II ("per polyp"), out of the 21 acromegalic patients included in this study, 12 presented normal findings at conventional colonoscopy. A total of 19 polyps were identified in 9 patients. Ten of the 19 polyps were smaller than 10 mm, and 9 were equal to or larger than 10 mm. Computed tomographic colonography identified 7 of the 9 polyps >10 mm described by conventional colonoscopy and only 6 of the 10 small polyps identified at conventional colonoscopy were detected by computed tomographic colonography. The histological analysis of resected lesions revealed 12 tubular adenomas, 6 hyperplastic polyps and 1 colonic tubulo-villous adenoma with an adenocarcinoma focus. CONCLUSION: The authors present the first reports of computed tomographic colonography in the screening of colorectal polyps in acromegalic patients. In this study, computed tomographic colonography was performed without complications and a complete and safe colorectal evaluation was possible in all acromegalic patients. Moreover, computed tomographic colonography presented good sensitivity, specificity and accuracy for the identification of acromegalic patients with polyps of any size and better results in the diagnosis of large polyps, when they were compared to small polypoid lesions.

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A comparison of normal versus low dietary carbohydrate intake on substrate oxidation during and after moderate intensity exercise in women

European Journal of Applied Physiology ◽

10.1007/s00421-011-1950-z ◽

2011 ◽

Vol 111 (12) ◽

pp. 3143-3150 ◽

Cited By ~ 5

Author(s):

Rachel Patterson ◽

Jeffrey A. Potteiger

Keyword(s):

Substrate Oxidation ◽

Carbohydrate Intake ◽

Moderate Intensity ◽

Dietary Carbohydrate ◽

Moderate Intensity Exercise

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A simplified table using validated diagnostic criteria is effective to improve characterization of colorectal polyps: the CONECCT teaching program

Endoscopy International Open ◽

10.1055/a-0962-9737 ◽

2019 ◽

Vol 07 (10) ◽

pp. E1197-E1206 ◽

Cited By ~ 1

Author(s):

Martin Fabritius ◽

Jean-Michel Gonzalez ◽

Aymeric Becq ◽

Xavier Dray ◽

Emmanuel Coron ◽

...

Keyword(s):

Colorectal Polyp ◽

Colorectal Polyps ◽

Treatment Choice ◽

Teaching Program ◽

Appropriate Treatment ◽

Post Test ◽

Choice Of Treatment ◽

Attending Physicians ◽

The Impact

Abstract Introduction and study aims Accurate real-time endoscopic characterization of colorectal polyps is key to choosing the most appropriate treatment. Mastering the currently available classifications is challenging. We used validated criteria for these classifications to create a single table, named CONECCT, and evaluated the impact of a teaching program based on this tool. Methods A prospective multicenter study involving GI fellows and attending physicians was conducted. During the first session, each trainee completed a pretest consisting in histological prediction and choice of treatment of 20 colorectal polyps still frames. This was followed by a 30-minute course on the CONECCT table, before taking a post-test using the same still frames reshuffled. During a second session at 3 – 6 months, a last test (T3 M) was performed, including these same still frames and 20 new ones. Results A total 419 participants followed the teaching program between April 2017 and April 2018. The mean proportion of correctly predicted/treated lesions improved significantly from pretest to post-test and to T3 M, from 51.0 % to 74.0 % and to 66.6 % respectively (P < 0.001). Between pretest and post-test, 343 (86.6 %) trainees improved, and 153 (75.4 %) at T3 M. Significant improvement occurred for each subtype of polyp for fellows and attending physicians. Between the two sessions, trainees continued to progress in the histology prediction and treatment choice of polyps CONECCT IIA. Over-treatment decreased significantly from 30.1 % to 15.5 % at post-test and to 18.5 % at T3 M (P < 0.001). Conclusion The CONECCT teaching program is effective to improve the histology prediction and the treatment choice by gastroenterologists, for each subtype of colorectal polyp.

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Urinary C-Peptide Excretion in Free-Living Healthy Children Is Related to Dietary Carbohydrate Intake but Not to the Dietary Glycemic Index1

Journal of Nutrition ◽

10.1093/jn/136.7.1828 ◽

2006 ◽

Vol 136 (7) ◽

pp. 1828-1833 ◽

Cited By ~ 6

Author(s):

Anette E. Buyken ◽

Yvonne Kellerhoff ◽

Sebastian Hahn ◽

Anja Kroke ◽

Thomas Remer

Keyword(s):

Carbohydrate Intake ◽

Healthy Children ◽

Dietary Carbohydrate ◽

Free Living ◽

C Peptide

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Associations of fat and carbohydrate intake with becoming overweight and obese: an 11-year longitudinal cohort study

British Journal Of Nutrition ◽

10.1017/s0007114520001579 ◽

2020 ◽

Vol 124 (7) ◽

pp. 715-728 ◽

Cited By ~ 1

Author(s):

Ya-Jing Cao ◽

Hui-Jun Wang ◽

Bing Zhang ◽

Su-Fen Qi ◽

Ying-Jun Mi ◽

...

Keyword(s):

Cox Model ◽

Overweight And Obesity ◽

Carbohydrate Intake ◽

Macronutrient Intake ◽

Dietary Carbohydrate ◽

Macronutrient Composition ◽

Total Fat ◽

The Relationship ◽

New Onset

AbstractThe effects of macronutrient intake on obesity are controversial. This research aims to investigate the associations between macronutrient intake and new-onset overweight/obesity. The relationship between the consumption of carbohydrate and total fat and obesity was assessed by the multivariable Cox model in this 11-year cohort, which included 6612 adults (3291 men and 3321 women) who were free of overweight and obesity at baseline. The dietary intake was recorded using a 24-h recall method for three consecutive days. Moreover, substitution models were developed to distinguish the effects of macronutrient composition alteration from energy intake modification. During 7·5 person years (interquartile range 4·3, 10·8) of follow-up, 1807 participants became overweight or obese. After adjusting for risk factors, the hazard ratio (HR) of overweight/obesity in extreme quintiles of fat was 1·48 (quintile 5 v. quintile 1, 95 % CI 1·16, 1·89; Ptrend = 0·02) in women. Additionally, replacing 5 % of energy from carbohydrate with equivalent energy from fat was associated with an estimated 4·3 % (HR 1·043, 95 % CI 1·007, 1·081) increase in overweight/obesity in women. Moreover, dietary carbohydrate was inversely associated with overweight/obesity (quintile 5 v. quintile 1, HR 0·70, 95 % CI 0·55, 0·89; Ptrend = 0·02) in women. Total fat was related to a higher risk of overweight/obesity, whereas high carbohydrate intake was related to a lower risk of overweight/obesity in women, which was not observed in men.

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