scholarly journals Association between tubal ligation and endometrial cancer risk: A Swedish population-based cohort study

2018 ◽  
Vol 143 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Henrik Falconer ◽  
Li Yin ◽  
Daniel Altman
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Tubal Ligation ◽  
Swedish Population ◽  
Endometrial Cancer Risk

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

scholarly journals Endometrial Cancer Incidence in Endometriosis and Adenomyosis

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4592
Author(s):  
Marjolein Hermens ◽  
Anne M. van Altena ◽  
Iris Velthuis ◽  
Danielle C. M. van de Laar ◽  
Johan Bulten ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Retrospective Cohort ◽  
Population Based ◽  
First Year ◽  
Endometrial Cancer Risk ◽  
Increased Risk

Women with histologically proven endometriosis/adenomyosis have an increased risk of ovarian cancer. Small studies show conflicting results on the endometrial cancer risk in women with endometriosis/adenomyosis. Therefore, we assessed the incidence of endometrial cancer in women with histologically proven endometriosis or adenomyosis. We performed a population-based retrospective cohort study of 129,862 women with histologically proven endometriosis/adenomyosis, matched with 132,700 women with a nevus selected from the Dutch pathology registry between 1990 and 2015. Histology results for endometrial cancer were retrieved. Crude and age-adjusted odds ratios for endometrial cancer were estimated. In the endometriosis/adenomyosis group, 1827 (1.4%) women had a histological report on endometrial cancer, and in the nevus group, 771 (0.6%) women. The age-adjusted OR for endometrial cancer was 2.58 (95%CI 2.37–2.81). After excluding the first year of follow-up, the age-adjusted OR was 0.76 (95%CI 0.63–0.92), indicating that endometrial cancer is most often found at time of histological diagnosis of endometriosis/adenomyosis. In around 20% of the endometrial cancer cases, the endometrial cancer was not recognized until after hysterectomy. Of these women, 35% had no prior (micro)curettage or biopsy. This study shows an increased incidence of endometrial cancer in women with histologically proven endometriosis and adenomyosis.

scholarly journals BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study

2020 ◽  
Vol 136 ◽  
pp. 169-175
Author(s):  
Sarah J. Kitson ◽  
Cemsel Bafligil ◽  
Neil A.J. Ryan ◽  
Fiona Lalloo ◽  
Emma R. Woodward ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Pathogenic Variant ◽  
Brca1 And Brca2 ◽  
Endometrial Cancer Risk

scholarly journals Glycaemic index, glycaemic load and risk of endometrial cancer: a prospective cohort study

2005 ◽  
Vol 8 (7) ◽  
pp. 912-919 ◽  
Author(s):  
Stephanie AN Silvera ◽  
Thomas E Rohan ◽  
Meera Jain ◽  
Paul D Terry ◽  
Geoffrey R Howe ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Hormone Replacement ◽  
Premenopausal Women ◽  
Glycaemic Index ◽  
Obese Women ◽  
Endometrial Cancer Risk ◽  
Glycaemic Load

AbstractObjectiveHigh-glycaemic-load diets may increase endometrial cancer risk by increasing circulating insulin levels and, as a consequence, circulating oestrogen levels. Given the paucity of epidemiological data regarding the relationship between dietary glycaemic index and glycaemic load and endometrial cancer risk, we sought to examine these associations using data from a prospective cohort study.Design, setting and subjectsWe examined the association between dietary glycaemic load and endometrial cancer risk in a cohort of 49 613 Canadian women aged between 40 and 59 years at baseline who completed self-administered food-frequency questionnaires between 1982 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000.ResultsDuring a mean of 16.4 years of follow-up, we observed 426 incident cases of endometrial cancer. Hazard ratios for the highest versus the lowest quartile level of overall glycaemic index and glycaemic load were 1.47 (95% confidence interval (CI) = 0.90–2.41; P for trend = 0.14) and 1.36 (95% CI = 1.01–1.84; P for trend = 0.21), respectively. No association was observed between total carbohydrate or total sugar consumption and endometrial cancer risk. Among obese women (body mass index > 30 kg m−2) the hazard ratio for the highest versus the lowest quartile level of glycaemic load was 1.88 (95% CI = 1.08–3.29; P for trend = 0.54) and there was a 55% increased risk for the highest versus the lowest quartile level of glycaemic load among premenopausal women. There was also evidence to support a positive association between glycaemic load and endometrial cancer risk among postmenopausal women who had used hormone replacement therapy.ConclusionsOur data suggest that diets with high glycaemic index or high glycaemic load may be associated with endometrial cancer risk overall, and particularly among obese women, premenopausal women and postmenopausal women who use hormone replacement therapy.

scholarly journals Racial/Ethnic Differences in Endometrial Cancer Risk: The Multiethnic Cohort Study

2006 ◽  
Vol 165 (3) ◽  
pp. 262-270 ◽  
Author(s):  
V. W. Setiawan ◽  
M. C. Pike ◽  
L. N. Kolonel ◽  
A. M. Nomura ◽  
M. T. Goodman ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Ethnic Differences ◽  
Endometrial Cancer Risk ◽  
Multiethnic Cohort ◽  
Racial Ethnic

Effect of raloxifene on endometrial cancer risk in a population-based, case-control study

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 5001-5001 ◽  
Author(s):  
A. Demichele ◽  
A. Troxel ◽  
A. Weber ◽  
J. Berlin ◽  
G. Bunin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Control Study

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology

2021 ◽  
Author(s):  
Rajani Sharma ◽  
Elizabeth C Verna ◽  
Tracey G Simon ◽  
Jonas Söderling ◽  
Hannes Hagström ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Cancer Risk ◽  
Autoimmune Hepatitis ◽  
Cox Regression ◽  
Population Based ◽  
Swedish Population ◽  
Non Melanoma Skin Cancer ◽  
Incident Cancer ◽  
Increased Risk

Abstract We aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish Cancer Register. During follow-up, a cancer diagnosis was made in 1,119 individuals with AIH (17.2/1000 person-years) and 4,450 reference individuals (12.0/1000 person-years). This corresponded to an HR of 1.53 (95%CI: 1.42,1.66). Cancer risk was highest in those with cirrhosis. There was a 29.18-fold increased risk of hepatocellular carcinoma (HCC) (95%CI, 17.52,48.61). The annual incidence risk of HCC in individuals with AIH who had cirrhosis was 1.1% per year. AIH was also linked to non-melanoma skin cancer (HR=2.69) and lymphoma (HR=1.89). Sibling analyses yielded similar risk estimates for any cancer (HR=1.84) and HCC (HR=23.10). AIH is associated with an increased risk of any cancer, in particular, HCC and extra-hepatic malignancies. The highest risk for cancer, especially HCC, is in patients with cirrhosis.

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