Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

2011 ◽  
Vol 30 (3-4) ◽  
pp. 363-385 ◽  
Author(s):  
Mary-Clare Cathcart ◽  
Joanne Lysaght ◽  
Graham P. Pidgeon
Keyword(s):  
Colorectal Cancer ◽  
Signalling Pathways ◽  
Prevention Intervention ◽  
Novel Approaches

scholarly journals Role of Vitamin D in Preventing Colorectal Carcinogenesis

2021 ◽  
Vol 11 ◽  
pp. 123-133
Author(s):  
Fauzan Herdian ◽  
Fahmi Radityamurti ◽  
Tiara Bunga Mayang Permata ◽  
Handoko Handoko ◽  
Henry Kodrat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Gene Transcription ◽  
Colorectal Adenoma ◽  
Relevant Literature ◽  
Colorectal Carcinogenesis ◽  
Signalling Pathways ◽  
Original Research ◽  
Metastatic Progression ◽  
Vitamin D Levels

Introduction: Colorectal carcinoma is one of the cancers with a high disease burden globally. Previous observational studies have found a connection between colorectal cancer incidence with sunlight exposure and vitamin D levels. Subsequent studies investigated this relationship further and found various anti-tumoral pathways regulated by vitamin D in colorectal tissue. This paper aims to elucidate the actions of those pathways in preventing the malignant transformation of the colorectal cell by reviewing relevant literature. Methods: A search was conducted on several medical literature electronic databases for original research studying the effects of vitamin D treatment on colorectal adenoma and colorectal cancer and its underlying anti-tumoral mechanism. A total of 122 studies were included for evaluation. Results: Twenty-seven studies passed for analysis. These in vitro and in vivo study reveals that vitamin D treatment can suppress cell proliferation, induce apoptosis, maintain cellular differentiation, reduce the pro-inflammatory response, inhibit angiogenesis, and hinder metastatic progression in colorectal cancer and colorectal adenoma cells by regulating associated gene transcription or directly prevents activation of selected signalling pathways. Five studies have also shown that adding calcium to vitamin D treatment increases the anti-tumoral activity of vitamin D through cross-talk between both of their pathways. Conclusion: Vitamin D could potentially impede colorectal cancer transformation and growth through interaction with various signalling pathways and regulating gene transcription. Further clinical studies are needed to confirm whether vitamin D can be used as the basis of targeted colorectal cancer therapy using its inherent anti-tumoral properties.

scholarly journals Does NLRP3 Inflammasome and Aryl Hydrocarbon Receptor Play an Interlinked Role in Bowel Inflammation and Colitis-Associated Colorectal Cancer?

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2427
Author(s):  
Ivan Qi Han Ngui ◽  
Agampodi Promoda Perera ◽  
Rajaraman Eri
Keyword(s):  
Colorectal Cancer ◽  
Immune System ◽  
Aryl Hydrocarbon Receptor ◽  
Nlrp3 Inflammasome ◽  
Intestinal Inflammation ◽  
Strong Association ◽  
Signalling Pathways ◽  
Inflammasome Activation ◽  
Intestinal Immunity ◽  
Aryl Hydrocarbon

Inflammation is a hallmark in many forms of cancer; with colitis-associated colorectal cancer (CAC) being a progressive intestinal inflammation due to inflammatory bowel disease (IBD). While this is an exemplification of the negatives of inflammation, it is just as crucial to have some degree of the inflammatory process to maintain a healthy immune system. A pivotal component in the maintenance of such intestinal homeostasis is the innate immunity component, inflammasomes. Inflammasomes are large, cytosolic protein complexes formed following stimulation of microbial and stress signals that lead to the expression of pro-inflammatory cytokines. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been extensively studied in part due to its strong association with colitis and CAC. The aryl hydrocarbon receptor (AhR) has recently been acknowledged for its connection to the immune system aside from its role as an environmental sensor. AhR has been described to play a role in the inhibition of the NLRP3 inflammasome activation pathway. This review will summarise the signalling pathways of both the NLRP3 inflammasome and AhR; as well as new-found links between these two signalling pathways in intestinal immunity and some potential therapeutic agents that have been found to take advantage of this link in the treatment of colitis and CAC.

The MAPK signalling pathways and colorectal cancer

2005 ◽  
Vol 6 (5) ◽  
pp. 322-327 ◽  
Author(s):  
Jing Yuan Fang ◽  
Bruce C Richardson
Keyword(s):  
Colorectal Cancer ◽  
Signalling Pathways ◽  
Mapk Signalling

scholarly journals A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Shengyang Qiu ◽  
Gianluca Pellino ◽  
Francesca Fiorentino ◽  
Shahnawaz Rasheed ◽  
Ara Darzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Studies ◽  
In Vivo Studies ◽  
Signalling Pathways ◽  
Diagnostic Biomarker ◽  
Gi Tract ◽  
Cellular Receptors

Neurotensin (NTS) is a physiologically occurring hormone which affects the function of the gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in the carcinogenesis of several cancers. In colorectal cancer (CRC), a significant body of evidence, from in vitro and in vivo studies, is available which elucidates the molecular biology of NTS/NTSR signalling and the resultant growth of CRC cells. There is growing clinical data from human studies which corroborate the role NTS/NTSR plays in the development of human CRC. Furthermore, blockade and modulation of the NTS/NTSR signalling pathways appears to reduce CRC growth in cell cultures and animal studies. Lastly, NTS/NTSR also shows potential of being utilised as a diagnostic biomarker for cancers as well as targets for functional imaging. We summarise the existing evidence and understanding of the role of NTS and its receptors in CRC.

Cannabinoids and cancer: potential for colorectal cancer therapy

2005 ◽  
Vol 33 (4) ◽  
pp. 712-714 ◽  
Author(s):  
H.A. Patsos ◽  
D.J. Hicks ◽  
A. Greenhough ◽  
A.C. Williams ◽  
C. Paraskeva
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Therapy ◽  
Surgical Techniques ◽  
Chemotherapeutic Agents ◽  
Signalling Pathways ◽  
The World ◽  
Endogenous Cannabinoids ◽  
Tumour Cell Growth ◽  
Stimulation Of

Despite extensive research into the biology of CRC (colorectal cancer), and recent advances in surgical techniques and chemotherapy, CRC continues to be a major cause of death throughout the world. Therefore it is important to develop novel chemopreventive/chemotherapeutic agents for CRC. Cannabinoids are a class of compounds that are currently used in the treatment of chemotherapy-induced nausea and vomiting, and in the stimulation of appetite. However, there is accumulating evidence that they could also be useful for the inhibition of tumour cell growth by modulating key survival signalling pathways. The chemotherapeutic potential for plant-derived and endogenous cannabinoids in CRC therapy is reviewed.

scholarly journals Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Annika Jacobsen ◽  
Linda J. W. Bosch ◽  
Sanne R. Martens-de Kemp ◽  
Beatriz Carvalho ◽  
Anke H. Sillars-Hardebol ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Aurora Kinase ◽  
Signalling Pathways ◽  
Aurora Kinase A ◽  
Mapk Signalling ◽  
Kinase A
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