Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis

Calendula officinalisis an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed thatC. officinalispresented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.

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M1762 Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis on TNBS-Induced Mouse Colitis Model

Gastroenterology ◽

10.1016/s0016-5085(10)61905-1 ◽

2010 ◽

Vol 138 (5) ◽

pp. S-414

Author(s):

Yosuke Abe ◽

Mitsuyuki Murano ◽

Naoko Murano ◽

Eijiro Morita ◽

Ken Kawakami ◽

...

Keyword(s):

Intestinal Fibrosis ◽

Anti Inflammatory ◽

Colitis Model ◽

Inflammatory Effect

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Efektifitas Anti Inflamasi Formulasi Kunyit (Curcuma Longa), Daun Binahong (Anredera Cordifolia) Dan Daun Sambiloto (Andrographis Paniculata) Terhadap Luka Sayat Pada Kelinci

Interest : Jurnal Ilmu Kesehatan ◽

10.37341/interest.v7i2.46 ◽

2018 ◽

Vol 7 (2) ◽

Author(s):

Kh Endah Widhi Astuti ◽

Sih Rini Handajani

Keyword(s):

Curcuma Longa ◽

Healing Process ◽

Andrographis Paniculata ◽

Control Group ◽

Wound Healing Process ◽

Second Stage Of Labor ◽

Post Test ◽

Treatment Research ◽

Anti Inflammatory ◽

Inflammatory Effect

Background: Perineal lacerations are tears that occur in the perineum because of the second stage of labor. The Javanese people do the purpose of this study is the effectiveness of anti-inflammatory formulation of turmeric (curcuma longa), leaves of Binahong (Anredera cordifolia) and leaves of Sambiloto (Andrographis paniculata) against incisions in rabbits. Method: The method used in this study is the method in this study. This research uses a quantitative method with a type of pure treatment research in the form of pre-post test design. The sample in this study was 10 rabbits per group in 5 groups. Results: There was an anti-inflammatory effect of the turmeric formulation, binahong leaves of bitter leaf (F1, F2 and F3) in the incision wound in rabbits (ρ <0.001). There is an anti-inflammatory effect of turmeric formulation, binahong leaves of bitter leaf on leukocyte levels in rabbit incisions in F1, F2 and F3 compared to the control group (ρ <0.001). Conclusion: Turmeric formula, binahong leaf, bitter leaf (F1, F2 and F3) in the incision in rabbits can improve the wound healing process.

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Effects of low laser level therapy in rehabilitation of patients with COVID19 pneumonia

Balneo and PRM Research Journal ◽

10.12680/balneo.2021.458 ◽

2021 ◽

pp. 323-326

Author(s):

Viorela Mihaela CIORTEA ◽

Mădălina Iliescu ILIESCU ◽

Eliza BLENDEA ◽

Irina MOTOASCA ◽

Ileana Monica BORDA ◽

...

Keyword(s):

Laser Therapy ◽

Healing Process ◽

Severe Pneumonia ◽

Laser Level ◽

Low Level Laser Therapy ◽

Health Crisis ◽

Public Health Crisis ◽

Level Laser ◽

Anti Inflammatory ◽

Inflammatory Effect

Introduction. An unprecedented public health crisis has been triggered worldwide by SARS-CoV-2’s high contagiosity and it’s mortality rates of 1-5%. Although the majority of COVID-19 cases have a good outcome, there is a small percentage that develop severe pneumonia and citokine storm and may be in the need of mechanical ventilation. Methods. Identifying the exact drivers of the excessive inflammation and the biomarkers that can predict a hyperinflammatory response to SARS-CoV-2 would be extremly helpful in finding efficient anti-inflammatory interventions that may stop the progression to acute respiratory distress syndrome (ARDS). Results. In the search for such interventions we have identified the promising effect of low level LASER therapy (LLLT) on lung inflammation from COVID-19 pneumonia. Due to its well known anti-inflammatory effect and modulatory activity on immune cells, laser therapy may be able to decrease lung and systemic inflammation without affecting lung function in acute lung lesions, relieve respiratory symptoms, normalize respiratory function and stimulate the healing process of lung tissue. The recovery time may also be significantly shortened and all blood, immunological and radiological parameters may improve. Conclusions. This findings need further confirmation from clinical trials but we are hopeful for their contribution on the global battle against COVID-19 pandemic. Keywords: SARS-CoV-2, pneumonia, low LASER level therapy, anti-inflammatory effect, citokine storm,

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Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process

Berkala Kedokteran ◽

10.20527/jbk.v14i2.5335 ◽

2018 ◽

Vol 14 (2) ◽

pp. 83

Author(s):

Maharani Laillyza Apriasari ◽

Dewi Puspitasari ◽

Amy Nindia Carabelly

Keyword(s):

Wound Healing ◽

Treatment Group ◽

Healing Process ◽

Positive Control ◽

Positive Control Group ◽

Control Group ◽

Wound Healing Process ◽

Inflammatory Phase ◽

Anti Inflammatory ◽

Inflammatory Effect

Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract

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Efektifitas Anti Inflamasi Formulasi Kunyit (Curcuma Longa), Daun Binahong (Anredera Cordifolia) Dan Daun Sambiloto (Andrographis Paniculata) Terhadap Luka Sayat Pada Kelinci

Interest : Jurnal Ilmu Kesehatan ◽

10.37341/interest.v8i1.124 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Kh Endah Widhi Astuti ◽

Sih Rini Handajani

Keyword(s):

Curcuma Longa ◽

Healing Process ◽

Andrographis Paniculata ◽

Control Group ◽

Wound Healing Process ◽

Second Stage Of Labor ◽

Post Test ◽

Treatment Research ◽

Anti Inflammatory ◽

Inflammatory Effect

Background: Perineal lacerations are tears that occur in the perineum because of the second stage of labor. The Javanese people do the purpose of this study is the effectiveness of the anti-inflammatory formulation of turmeric (Curcuma longa), leaves of Binahong (Anredera cordifolia) and leaves of Sambiloto (Andrographis paniculata) against incisions in rabbits. Method: The method used in this study is the method in this study. This research uses a quantitative method with a type of pure treatment research in the form of a pre-post test design. The sample in this study was 10 rabbits per group in 5 groups. Results: There was an anti-inflammatory effect of the turmeric formulation, binahong leaves of bitter leaf (F1, F2, and F3) in the incision wound in rabbits (ρ <0.001). There is an anti-inflammatory effect of turmeric formulation, binahong leaves of a bitter leaf on leukocyte levels in rabbit incisions in F1, F2, and F3 compared to the control group (ρ <0.001). Conclusion: Turmeric formula, binahong leaf, bitter leaf (F1, F2, and F3) in the incision in rabbits can improve the wound healing process.

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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