RGD-conjugated titanium dioxide nanoparticles: targeted near-infrared photothermal therapy for αvβ3 integrin overexpressed cancer cells

2017 ◽  
Vol 52 (23) ◽  
pp. 13356-13364 ◽  
Author(s):  
Heng Zhao ◽  
Min Wang ◽  
Ping Zhou ◽  
Quan Wang ◽  
Zhiguo Zhou ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Titanium Dioxide Nanoparticles ◽  
Αvβ3 Integrin

scholarly journals NEAR INFRARED LIGHT HEATING OF SOFT TISSUE PHANTOMS CONTAINING NANOPARTICLES

2014 ◽  
Vol 13 (1) ◽  
pp. 13
Author(s):  
S. Eibner ◽  
R. A. O. Jaime ◽  
B. Lamien ◽  
R. L. Q. Basto ◽  
H. R. B. Orlande ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Soft Tissue ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Titanium Dioxide Nanoparticles ◽  
Local Heating ◽  
Infrared Camera ◽  
Infrared Light ◽  
Thermal Paste ◽  
Tissue Phantoms

The objective of this paper is to investigate the effect of the addition of nanoparticles to soft tissue phantoms, aiming at the enhancement of photothermal therapy for cancer. The phantoms were made of Polyvinyl chloride-plastisol (PVC-P), with two different nanoparticles, namely, titanium dioxide nanoparticles (TiO2) and silica nanoparticles (SiO2). A phantom without nanoparticles and a phantom containing a thermal paste were also manufactured for comparison purposes. The PVC-P phantom is transparent to the near infrared laser light, whereas the addition of titanium dioxide nanoparticles modified the optical properties enhancing the local heating, as demonstrated through experiments with a laser-diode and an infrared camera.

scholarly journals Facile fabricating of rGO and Au/rGO nanocomposites using Brassica oleracea var. gongylodes biomass for non-invasive approach in cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fatemeh Yousefimehr ◽  
Saeed Jafarirad ◽  
Roya Salehi ◽  
Mohammad Sadegh Zakerhamidi
Keyword(s):  
Breast Cancer ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Brassica Oleracea ◽  
Photothermal Therapy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Therapeutic Effects ◽  
Invasive Approach ◽  
Au Nps

AbstractIn this study, we report a facile green-synthesis route for the fabrication of reduced graphene oxide (rGO) using biomass of Brassica oleracea var. gongylodes (B. oleracea). In addition, we have attempted to provide a green synthesis approach to prepare Gold nanoparticles (Au NPs) on the surface of rGO by using stem extract of B. oleracea. The synthesized Au/rGO nanocomposite was evaluated using UV–visible and FTIR spectroscopy, XRD, Raman, FE-SEM, EDX, AFM and DLS techniques. The obtained results demonstrated that the synthesized Au NPs on the surface of rGO was spherical with sizes ranging about 12–18 nm. The Au/rGO NC was, also, developed as photo-synthesizer system for the photothermal therapy (PTT) of MCF7 breast cancer cells. The near-infrared (NIR) photothermal properties of Au/rGO NCs was evaluated using a continuous laser at 808 nm with power densities of 1 W.cm−2. Their photothermal efficacy on MCF7 breast cancer cells after optimizing the proper concentration of the NCs were evaluated by MTT assay, Cell cycle and DAPI staining. In addition, the potential of the synthesized Au/rGO NCs on reactive oxygen species generating and antioxidant activity were assessed by DPPH. Au/rGO NCs possess high capacity to light-to-heat conversion for absorption in range NIR light, and it is able to therapeutic effects on MCF7 cells at a low concentration. The maximum amount of cell death is 40.12% which was observed in treatment groups that received a combination of Au/rGO NCs and laser irradiation. The results demonstrate that the nanomaterials synthesized by green approach lead to efficient destruction of cancer cell and might thus serve as an excellent theranostic agent in Photothermal therapy applications.

scholarly journals Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoxia Song ◽  
Zhi Chen ◽  
Xue Zhang ◽  
Junfeng Xiong ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Stimuli Responsive ◽  
Lung Cancer Cell ◽  
Precise Movement ◽  
Photothermal Property

AbstractMagnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

Corrigendum: Near‐infrared emissive polymer‐coated IR‐820 nanoparticles assisted photothermal therapy for cervical cancer cells

2022 ◽  
Author(s):  
Lijun Zhu ◽  
Jianjun Chen ◽  
Ting Yan ◽  
Gulinigaer Alimu ◽  
Xueliang Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cervical Cancer Cells

scholarly journals Induction of Apoptosis and Inhibition of Invasion in Gastric Cancer Cells by Titanium Dioxide Nanoparticles

2018 ◽  
Vol 33 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Reza Nasr ◽  
Hadi Hasanzadeh ◽  
Ali Khaleghian ◽  
Abdolvahab Moshtaghian ◽  
Alireza Emadi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Titanium Dioxide ◽  
Cancer Cells ◽  
Titanium Dioxide Nanoparticles ◽  
Gastric Cancer Cells ◽  
Induction Of Apoptosis

PEGylated nickel carbide nanocrystals as efficient near-infrared laser induced photothermal therapy for treatment of cancer cells in vivo

Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 12591-12600 ◽  
Author(s):  
Zhiguo Zhou ◽  
Jun Wang ◽  
Wei Liu ◽  
Chao Yu ◽  
Bin Kong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Nickel Carbide

scholarly journals RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles –switchableintegrin-targeted photodynamic treatment of melanoma cells

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9112-9119 ◽  
Author(s):  
Avraham Dayan ◽  
Gideon Fleminger ◽  
Osnat Ashur-Fabian
Keyword(s):  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
High Selectivity ◽  
Titanium Dioxide Nanoparticles ◽  
Melanoma Cells ◽  
Dihydrolipoamide Dehydrogenase ◽  
Photodynamic Treatment ◽  
Targeted Photodynamic Therapy

This work presents a UVA switchable integrin-targeted photodynamic therapy in melanoma, composed of an RGD-modified DLDH conjugated to TiO2nanoparticles, with high selectivity towards integrin-expressing cancer cells.

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