Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro

2015 ◽  
Vol 26 (10) ◽  
Author(s):  
Da-Jun Lin ◽  
Fei-Yi Hung ◽  
Ming-Long Yeh ◽  
Truan-Sheng Lui
Keyword(s):  
Wound Healing ◽  
Magnesium Alloy ◽  
Biodegradable Magnesium

In vitro degradation behavior and cytocompatibility of a bioceramic anodization films on the biodegradable magnesium alloy

2016 ◽  
Vol 488 ◽  
pp. 82-92 ◽  
Author(s):  
Hamouda M. Mousa ◽  
Kamal H. Hussein ◽  
Hem Raj Pant ◽  
Heung M. Woo ◽  
Chan Hee Park ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Degradation Behavior ◽  
In Vitro Degradation ◽  
Biodegradable Magnesium

Surface microstructure and in vitro analysis of nanostructured akermanite (Ca2MgSi2O7) coating on biodegradable magnesium alloy for biomedical applications

2014 ◽  
Vol 117 ◽  
pp. 432-440 ◽  
Author(s):  
Mehdi Razavi ◽  
Mohammadhossein Fathi ◽  
Omid Savabi ◽  
Batoul Hashemi Beni ◽  
Daryoosh Vashaee ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Biomedical Applications ◽  
Surface Microstructure ◽  
Vitro Analysis ◽  
Biodegradable Magnesium ◽  
In Vitro Analysis

Cytotoxicity of biodegradable magnesium alloy WE43 to tumor cells in vitro: Bioresorbable implants with antitumor activity?

2019 ◽  
Vol 108 (1) ◽  
pp. 167-173 ◽  
Author(s):  
Natalia Anisimova ◽  
Mikhail Kiselevskiy ◽  
Natalia Martynenko ◽  
Boris Straumal ◽  
Regine Willumeit‐Römer ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Antitumor Activity ◽  
Tumor Cells ◽  
Alloy We43 ◽  
Bioresorbable Implants ◽  
Biodegradable Magnesium

scholarly journals Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors

2020 ◽  
Author(s):  
Nailin Yang ◽  
Fei Gong ◽  
Liang Cheng ◽  
Huali Lei ◽  
Wei Li ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Thermal Effect ◽  
Field Intensity ◽  
Magnetic Hyperthermia ◽  
Low Field ◽  
Hyperthermia Therapy ◽  
Biodegradable Magnesium ◽  
First Time

Abstract Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF) to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material, magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, MgA rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of MgA rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and ∼20% of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable MgA, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.

scholarly journals In vitro and in vivo studies on biodegradable magnesium alloy

2014 ◽  
Vol 24 (5) ◽  
pp. 466-471 ◽  
Author(s):  
Lida Hou ◽  
Zhen Li ◽  
Yu Pan ◽  
Li Du ◽  
Xinlin Li ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
In Vivo Studies ◽  
Biodegradable Magnesium
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