What happens to the interfacial reaction between fluoropolymer and nano aluminum below 1000 ℃?

The aim of the study is to formulate a modified release chitosan nanoparticles for the oral delivery of atorvastatin and to study the in vitro release of atorvastatin from chitosan nanoparticles. Atorvastatin-loaded chitosan nanoparticles were prepared with different concentration of cross-linking agent (glutaraldehyde) by emulsion interfacial reaction method. The formed nanoparticles were characterized in terms of size and morphological characteristics by scanning electron microscopy (SEM) and transmission electron microscope (TEM). Spherical and regular nanoparticles with the size range of 100-250nm were formed. Atorvastatin encapsulation efficiency of nanoparticles was found to be highest in ANP3, followed by ANP2 and ANP1. The in vitro release of atorvastatin was studied by membrane diffusion technique. The resulted cumulative percentage of drug released for ANP1, ANP2 and ANP3 were 60.08%, 34.81% and 20.39% respectively. Through this study, the nanoparticles preparation technique has shown to be a promising approach for enhancing the dissolution of hydrophobic drugs like atorvastatin calcium. The application of this novel delivery system offers good therapeutic potential in the management of hypercholesterolemia and dyslipidemia.

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Preparation and Evaluation of Chitosan Loaded Naproxen Nanoparticles by Emulsion Interfacial Reaction Method

Drug Delivery Letters ◽

10.2174/2210303109666190211150117 ◽

2019 ◽

Vol 9 (2) ◽

pp. 89-96

Author(s):

Abbaraju Krishna Sailaja ◽

Juveria Banu

Keyword(s):

Drug Release ◽

Interfacial Reaction ◽

Polymer Concentration ◽

Chitosan Nanoparticles ◽

Particle Diameter ◽

Entrapment Efficiency ◽

Reaction Method ◽

Release Data ◽

Mean Particle Diameter

Aim: The aim of this investigation was to develop and characterize naproxen loaded chitosan nanoparticles by emulsion interfacial reaction method. Methodology: For emulsion interfacial reaction method chitosan was used as a polymer. In this method, eight formulations were prepared by varying drug to polymer concentration. Discussion: Out of eight formulations prepared using emulsion interfacial reaction method EI8 formulation was found to be the best formulation. The drug content was observed as 94.4%, entrapment efficiency and loading capacity were found to be 87.5% and 75%, respectively. The mean particle diameter was measured as 324.6nm and the Zeta potential value was found to be -42.4mv. In vitro drug release data showed 97.2% of drug release rate sustained up to 12hrs. Conclusion: The results clearly reveal that EI8 formulation having the highest amount of drug was considered as the best formulation because of its small mean particle diameter, good entrapment efficiency, and stability.

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Interfacial reaction in squeeze cast SICW/AZ91 magnesium alloy composite

Scripta Materialia ◽

10.1016/1359-6462(96)00169-8 ◽

1996 ◽

Vol 35 (4) ◽

pp. 529-534 ◽

Cited By ~ 21

Author(s):

Kun Wu ◽

Mingyi Zheng ◽

Min Zhao ◽

Congkai Yao ◽

Jihong Li

Keyword(s):

Magnesium Alloy ◽

Interfacial Reaction ◽

Alloy Composite ◽

Az91 Magnesium Alloy ◽

Squeeze Cast ◽

Az91 Magnesium

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The oxidation performance and interfacial reaction behavior of YSZ-ZrB2 incorporated glass composite coating

Corrosion Science ◽

10.1016/j.corsci.2021.109622 ◽

2021 ◽

pp. 109622

Author(s):

Jing-Jia Wu ◽

Hao-Jie Yan ◽

Fa-He Cao ◽

Lian-Kui Wu

Keyword(s):

Composite Coating ◽

Interfacial Reaction ◽

Glass Composite ◽

Reaction Behavior ◽

Oxidation Performance

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A dynamic reaction density functional theory for interfacial reaction-diffusion coupling at nanoscale

Chemical Engineering Science ◽

10.1016/j.ces.2021.116513 ◽

2021 ◽

Vol 236 ◽

pp. 116513 ◽

Cited By ~ 2

Author(s):

Weiqiang Tang ◽

Hongping Yu ◽

Teng Zhao ◽

Leying Qing ◽

Xiaofei Xu ◽

...

Keyword(s):

Density Functional Theory ◽

Interfacial Reaction ◽

Density Functional ◽

Reaction Diffusion ◽

Dynamic Reaction ◽

Functional Theory ◽

Diffusion Coupling

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Interface Behavior of Brazing between Zr-Cu Filler Metal and SiC Ceramic

Crystals ◽

10.3390/cryst11070727 ◽

2021 ◽

Vol 11 (7) ◽

pp. 727

Author(s):

Bofang Zhou ◽

Taohua Li ◽

Hongxia Zhang ◽

Junliang Hou

Keyword(s):

Interfacial Reaction ◽

Reaction Layer ◽

Chemical Potential ◽

Filler Metal ◽

Diffusion Constant ◽

Interface Reaction ◽

Diffusion Path ◽

Interface Behavior ◽

Interfacial Reaction Layer ◽

Sic Ceramic

The interface behavior of brazing between Zr-Cu filler metal and SiC ceramic was investigated. Based on the brazing experiment, the formation of brazing interface products was analyzed using OM, SEM, XRD and other methods. The stable chemical potential phase diagram was established to analyze the possible diffusion path of interface elements, and then the growth behavior of the interface reaction layer was studied by establishing relevant models. The results show that the interface reaction between the active element Zr and SiC ceramic is the main reason in the brazing process the interface products are mainly ZrC and Zr2Si and the possible diffusion path of elements in the product formation process is explained. The kinetic equation of interfacial reaction layer growth is established, and the diffusion constant (2.1479 μm·s1/2) and activation energy (42.65 kJ·mol−1) are obtained. The growth kinetics equation of interfacial reaction layer thickness with holding time at different brazing temperatures is obtained.

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