Accumulation mechanism of nanoparticles around photothermally generated surface bubbles

2021 ◽  
Vol 23 (8) ◽  
Author(s):  
Koki Okada ◽  
Kento Kodama ◽  
Ken Yamamoto ◽  
Masahiro Motosuke
2021 ◽  
Vol 10 (8) ◽  
pp. 1768
Author(s):  
Zhitao Wang ◽  
Rui Jiang ◽  
Qian Li ◽  
Huiping Wang ◽  
Qianshan Tao ◽  
...  

Myeloid-derived suppressor cells (MDSCs) are defined as negative regulators that suppress the immune response through a variety of mechanisms, which usually cluster in cancer, inflammation, and autoimmune diseases. This study aims to investigate the correlation between M-MDSCs and the clinical features of diffuse large B-cell lymphoma (DLBCL) patients, as well as the possible accumulation mechanism of M-MDSCs. The level of M-MDSCs is significantly increased in newly diagnosed and relapsed DLBCL patients. Regarding newly diagnosed DLBCL patients, the frequency of M-MDSCs is positively correlated with tumor progression and negatively correlated with overall survival (OS). More importantly, the level of M-MDSCs can be defined as a biomarker for a poor prognosis in DLBCL patients. Additionally, interleukin-35 (IL-35) mediates the accumulation of M-MDSCs in DLBCL patients. Anti-IL-35 treatment significantly reduces levels of M-MDSCs in Ly8 tumor-bearing mice. Thus, M-MDSCs are involved in the pathological process of DLBCL. Targeting M-MDSCs may be a promising therapeutic strategy for the treatment of DLBCL patients.


Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 255
Author(s):  
Ziyi Luo ◽  
Hao Xu ◽  
Liwei Liu ◽  
Tymish Y. Ohulchanskyy ◽  
Junle Qu

Alzheimer’s disease (AD) is a multifactorial, irreversible, and incurable neurodegenerative disease. The main pathological feature of AD is the deposition of misfolded β-amyloid protein (Aβ) plaques in the brain. The abnormal accumulation of Aβ plaques leads to the loss of some neuron functions, further causing the neuron entanglement and the corresponding functional damage, which has a great impact on memory and cognitive functions. Hence, studying the accumulation mechanism of Aβ in the brain and its effect on other tissues is of great significance for the early diagnosis of AD. The current clinical studies of Aβ accumulation mainly rely on medical imaging techniques, which have some deficiencies in sensitivity and specificity. Optical imaging has recently become a research hotspot in the medical field and clinical applications, manifesting noninvasiveness, high sensitivity, absence of ionizing radiation, high contrast, and spatial resolution. Moreover, it is now emerging as a promising tool for the diagnosis and study of Aβ buildup. This review focuses on the application of the optical imaging technique for the determination of Aβ plaques in AD research. In addition, recent advances and key operational applications are discussed.


1981 ◽  
Vol 77 (1) ◽  
pp. 77-93 ◽  
Author(s):  
D C Spray ◽  
A L Harris ◽  
M V Bennett

The conductance of junctions between amphibian blastomeres is strongly voltage dependent. Isolated pairs of blastomeres from embryos of Ambystoma mexicanum, Xenopus laevis, and Rana pipiens were voltage clamped, and junctional current was measured during transjunctional voltage steps. The steady-state junctional conductance decreases as a steep function of transjunctional voltage of either polarity. A voltage-insensitive conductance less than 5% of the maximum remains at large transjunctional voltages. Equal transjunctional voltages of opposite polarities produce equal conductance changes. The conductance is half maximal at a transjunctional voltage of approximately 15 mV. The junctional conductance is insensitive to the potential between the inside and outside of the cells. The changes in steady-state junctional conductance may be accurately modeled for voltages of each polarity as arising from a reversible two-state system in which voltage linearly affects the energy difference between states. The voltage sensitivity can be accounted for by the movement of about six electron charges through the transjunctional voltage. The changes in junctional conductance are not consistent with a current-controlled or ionic accumulation mechanism. We propose that the intramembrane particles that comprise gap junctions in early amphibian embryos are voltage-sensitive channels.


1989 ◽  
Vol 37 (2) ◽  
pp. 450-453 ◽  
Author(s):  
Hisahiro YOSHIDA ◽  
Katsuhiko OKUMURA ◽  
Akira KAMIYA ◽  
Ryohei HORI

2021 ◽  
Author(s):  
Dengyi Xiao ◽  
Mingsheng Lv ◽  
Guangcheng Hu ◽  
Wenyuan Tian ◽  
Li Wang ◽  
...  

Abstract In Western UAE, the Middle Cretaceous petroleum system is composed of Shilaif source, Mishrif/Tuwayil reservoir and Tuwayil/Ruwaydha seal. Oil is discovered in Tuwayil sandstone in DH and NN fields. Well correlation of Tuwayil siliciclastic interval shows high heterogeneity and rapid lithology varies. Currently, a few general studies about Tuwayil sandstone was published. However, detailed sedimentary facies, reservoir characteristics and accumulation mechanism about Tuwayil are ambiguous. Limitation on these aspects prohibits enlarging exploration activity of Tuwayil and makes barriers to deepen understanding of the whole K2 PS. To enhance understanding on Tuwayil formation, well data in DH, NN fields and adjacent area was integrated. Dedicated single well analysis, well correlation and petrophysics study were carried out. Cores were observed and laboratory outcomes including TS, SEM, RCA, MICP, XRD were adopted into this study. Furthermore, we have also utilized 2D&3D seismic to illustrate the spatial distribution of Tuwayil siliciclastic setting and interior sediment pattern. Basically, the Tuwayil sand-shale interval represents the infilling of Mishrif/Shilaif intrashelf basin and mainly deposits in the tidal flat-delta facies. The epi-continental clast is sourced from the Arabian shield and transferred from west to east. In Western UAE, the Tuwayil depocenter located in DH field, where 4-5 sand layers deposit with net pay of 30-40ft. In NN field, only one sand layer develops with net pay about 4-6ft. Through deposition cycles identification and seismic reflection observation, two sand groups could be recognized in this interval. The lower group is constrained in the depocenter and influenced by the paleo-geomorphology background. The upper group overpassed the former set and pinched out around north of NN. The Mishrif/Shilaif slope area is another potential belt to enlarge Tuwayil discovery, where stratigraphic onlap could be observed and it probably represents the sand pinch-out in lower sand group. For the K2 PS, previous study believed the shale between Tuwayil sand and Mishrif separate these two reservoirs and works as cap rock for Mishrif grainstone. This study suggests that this shale is too thin and not continuous enough to hold the hydrocarbon in Mishrif. On that note, Tuwayil sand and Mishrif belong to the same petroleum system in NN and may have the same OWC. In the NN field, it is quite crucial to consider the extension of Tuwayil sand during evaluating the stratigraphic prospect of Mishrif because the hydrocarbon is mostly likely charged Tuwayil sand first and then gets into underlain Mishrif. This study provides updates and understandings on sedimentary facies, depositional pattern, hydrocarbon accumulation mechanism, reservoir extension and potential identification of Tuwayil formation, which has inspiring implications for the whole K2 PS and could also de-risk the further exploration activity in Western UAE.


Manufacturing ◽  
2002 ◽  
Author(s):  
Jun Lian ◽  
Zhongqin Lin ◽  
Fusheng Yao ◽  
Xinmin Lai

In the assembly process of auto-body, variations in the geometrical dimensions of sheet metal parts and fixtures are inevitable. These variations accumulate through the multi-station assembly process to form the dimensional variations of the final products. Compared with the assembly of rigid parts, the assembly process of the elastic parts is more complex because the variation accumulation patterns rely much on the variations of fixture, jointing methods and mechanical deformation. This paper aims at analyzing the variation transformation mechanism and accumulation characteristics for the assembly of sheet metal parts based on the analysis of dimensional coordination relations among parts and fixtures. Finite element method (FEM) and Monte-Carlo Simulation (MCS) were used to analyze the effect of jointing contact on variation transformation, while a state equation was developed to describe the variation accumulation mechanism. The result of the analysis indicates that the main characteristics of elastic assembly jointing are the overlap jointing methods and elastic contacts action. The fact that the variation transform coefficients (VTC) are variable makes the assembly variation distribution Non-Gaussian even if the dimension variation of parts is Gaussian distribution. The analysis conclusions have potential value for more reasonable tolerance synthesis of elastic parts assembly.


Sign in / Sign up

Export Citation Format

Share Document