Quality of life following awake surgery depends on ability of executive function, verbal fluency, and movement

2021 ◽  
Author(s):  
Riho Nakajima ◽  
Masashi Kinoshita ◽  
Hirokazu Okita ◽  
Mitsutoshi Nakada
Keyword(s):  
Quality Of Life ◽  
Executive Function ◽  
Verbal Fluency ◽  
Awake Surgery

QOLP-18. QUALITY OF LIFE IN GLIOMAS WHO UNDERWENT AWAKE SURGERY DEPENDS ON RETURN TO SOCIAL LIFE, ABILITY OF MOVEMENT AND VERBAL FLUENCY

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi186-vi187
Author(s):  
Riho Nakajima ◽  
Masashi Kinoshita ◽  
Hirokazu Okita ◽  
Mitsutoshi Nakada
Keyword(s):  
Quality Of Life ◽  
Motor Function ◽  
Verbal Fluency ◽  
Social Life ◽  
Awake Surgery ◽  
Clinical Factors ◽  
Factors Influencing ◽  
Sf 36 ◽  
Functional Factors

Abstract Awake surgery is performed aiming for maintaining postoperative quality of life (QOL) by preserving brain function. Nowadays, it is not known whether QOL is certainly maintained in gliomas who underwent awake surgery, and which brain functions contribute to maintain their postoperative QOL. Here we investigated QOL following awake surgery, and to determine their background and functional factors influencing on QOL. Totally 80 patients with gliomas were matched our inclusion criteria. SF-36 was performed for assessment of QOL. Three component scores including physical component summary (PCS), mental component summary (MCS), and role/social component summary (RCS) were calculated, and were compared them with that of normal healthy controls. Additionally, neurological/neuropsychological functions were evaluated at pre- and post-operative six months. Multiple regression analyses were used to investigate functional and sociodemographic/clinical factors influencing on SF-36. RCS but not PCS and MCS in patient group was significantly lower than that of normal controls (p< .0001). Then, we investigated sociodemographic/clinical factors influencing on RCS, and found two significant factors, returning to social life and malignancy grade (p=0.011 and 0.022, respectively). The primary reasons for difficulty in returning to social life were functional deficits including aphasia and paresis. Among functional factors, RCS significantly related to motor function and verbal fluency (p= 0.0042 and 0.040, respectively). To support the results, RCS in deficit group for movement and verbal fluency was significantly low than in non-deficit group (Wilcoxon test, p=0.037 and 0.044, respectively). Among factors influencing on RCS, sociodemographic/clinical factors were returning to social life and malignancy grade, while functional factors were motor function and verbal fluency.

Predictors of Social Function and Quality of Life in Patients with Traumatic Brain Injury

2017 ◽  
Vol 41 (S1) ◽  
pp. s792-s792 ◽  
Author(s):  
S. Ubukata ◽  
G. Sugihara ◽  
T. Murai ◽  
K. Ueda
Keyword(s):  
Quality Of Life ◽  
Traumatic Brain Injury ◽  
Executive Function ◽  
Verbal Fluency ◽  
Functional Outcomes ◽  
Social Function ◽  
Depressive Mood ◽  
Physical Symptoms ◽  
Fluency Test

Cognitive deficits as well as affective and physical symptoms are common after traumatic brain injury (TBI). However, little is known about how these deficits affect functional outcomes. The purpose of this study was to investigate the relationship between neuropsychological, affective and physical sequelae and outcomes such as social function and quality of life in patients with TBI. We studied these relationships in 57 patients with TBI over the course of 6 months post-injury. The patients completed neuropsychological assessments, including the Wechsler Adult Intelligence Scale-III, the Rivermead Behavioural Memory Test, and verbal fluency test. Affective and physical symptoms were assessed by beck depression inventory-II, Chalder fatigue scale, and Pittsburgh sleep quality index. Functional outcomes were assessed using the world health organization (WHO) disability assessment rated by others and the WHO quality of life assessment (WHO/QOL 26). The patients showed impairments in executive function assessed by verbal fluency test. The affective and physical assessments showed mild depressive mood and fatigue problem. Multiple regression analysis revealed that executive function and depressive mood were the best predictors of social function and quality of life, respectively. The findings of this study suggest that executive function and depressive mood are important factors to predict functional outcomes in patients with TBI.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Adult ADHD, Executive Function, Depressive/Anxiety Symptoms, and Quality of Life: A serial two-mediator model

2021 ◽  
Author(s):  
Zhang Shi-Yu ◽  
Qiu Sun-Wei ◽  
Pan Mei-Rong ◽  
Zhao Meng-Jie ◽  
Zhao Rong-Jia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Executive Function ◽  
Adult Adhd ◽  
Anxiety Symptoms

scholarly journals QOLP-02. PRESERVING FUNCTIONS OF LANGUAGE, MOTOR, AND WORKING MEMORY BY AWAKE MAPPING CONTRIBUTES TO MAINTAIN QUALITY OF LIFE IN GLIOMAS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi197-vi197
Author(s):  
Riho Nakajima ◽  
Masashi Kinoshita ◽  
Hirokazu Okita ◽  
Mitsutoshi Nakada
Keyword(s):  
Quality Of Life ◽  
Working Memory ◽  
Regression Analysis ◽  
Healthy Volunteers ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Awake Surgery ◽  
Brain Functions ◽  
Sf 36

Abstract INTRODUCTION Aims of awake surgery are considered as maximum resection and functional preservation for postoperative quality of life (QOL). However, any studies have not been focused on the fundamental hypothesis that preservation of brain functions contributes to patient’s QOL. In this study, we investigated postoperative QOL and its related factors to reveal contribution of awake surgery for maintaining QOL. METHODS A total of 63 patients who underwent awake surgery were studied. Several kinds of neuropsychological/neurological tests and SF-36 to assess QOL were performed at 6-month postoperatively. In SF-36, 3-component scores, including physical, mental, and role/social component were calculated and they were compared with healthy volunteers. Additionally, their background factors were collected from medical records. Then, influenced background and functional factors to QOL were analyzed using multiple regression analysis. Moreover, voxel-based lesion symptom (VLSM) analyses were performed to investigate relationship between resected regions and QOL. RESULTS Though physical and mental QOL scores were almost equivalent to healthy volunteers, role and social component score (RCS) were significantly declined (36.7, < .0001). Using multiple regression analysis, RCS significantly related to reinstatement among several background factors (p=0.0038). Until postoperative 6 months, 71.6% returned to professional work. Moreover, RCS correlated significantly with working memory, language, and motor function among several brain functions (p=0.019, 0.0028, 0.010, respectively). In the VLSM analysis, patients who resected following regions showed significantly low RCS; the left inferior frontal and superior to middle temporal gyri which relate to language; and right supplementary motor area and cingulate cortex which are involved in motor control or working memory. CONCLUSIONS The important factors to maintain QOL are reinstatement and preserving brain functions including language, motor, and working memory. This suggests that awake surgery aiming for preserving these functions is a benefit for postoperative QOL.

scholarly journals Do Patients With Advanced Cancer Have the Ability to Make Informed Decisions for Participation in Phase I Clinical Trials?

2018 ◽  
Vol 36 (24) ◽  
pp. 2483-2491 ◽  
Author(s):  
Fay J. Hlubocky ◽  
Greg A. Sachs ◽  
Eric R. Larson ◽  
Halla S. Nimeiri ◽  
David Cella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Executive Function ◽  
Phase I ◽  
Advanced Cancer ◽  
Phase I Trials ◽  
Trail Making Test ◽  
Phase I Clinical Trials ◽  
Trail Making

Purpose Patients with advanced cancer (ACPs) participating in phase I clinical trials inadequately understand many elements of informed consent (IC); however, the prevalence and impact of cognitive impairment has not been described. Patients and Methods ACPs enrolled onto phase I trials underwent neuropsychological assessment to evaluate cognitive functioning (CF) covering the following domains: memory (Hopkins Verbal Learning Test), executive functioning (Trail Making Test B), language (Boston Naming Test-Short Version and Controlled Oral Word Association Test), attention (Trail Making Test A and Wechsler Adult Intelligenence Scale-IV Digit Span), comprehension (Wechsler Adult Intelligence Scale-IV), and quality of life (Functional Assessment of Cancer Therapy–Cognitive Function). Structured interviews evaluated IC and decisional capacity. Psychological measures included distress (Hospital Anxiety Depression Scale) and depression (Beck Depression Inventory-II). Results One hundred eighteen ACPs on phase I trials were evaluated, with CF ranging from mild impairment to superior performance. Only 45% of ACPs recalled physician disclosure of the phase I trial purpose. The 50% of ACPs who correctly identified the phase I research purpose had greater CF compared with ACPs who did not, as revealed by the mean T scores for memory (37.2 ± 5.6 v 32.5 ± 5.1, respectively; P = .001), attention (29 ± 2.7 v 26.9 ± 2.4, respectively; P < .001), visual attention (35.2 ± 6.6 v 31.5 ± 6.2, respectively; P = .001), and executive function (38.9 ± 7.5 v 34 ± 7.1, respectively; P < .001). Older ACPs (≥ 60 years) were less likely to recall physician disclosure of phase I purpose than younger ACPs (30% v 70%, respectively; P = .02) and had measurable deficits in total memory (34.2 ± 5.0 v 37.3 ± 5.6, respectively; P = .002), attention (24.5 ± 2.6 v 28 ± 2.8, respectively; P < .001), and executive function (32.8 ± 7.3 v 36.4 ± 7.6, respectively; P = .01). Older ACPs, compared with younger ACPs, also had greater depression scores (10.6 ± 9.2 v 8.1 ± 5.2, respectively; P = .03) and lower quality-of-life scores (152 ± 29.6 v 167 ± 20, respectively; P = .03). After adjustment by age, no psychological or neuropsychological variable was further significantly associated with likelihood of purpose identification. Conclusion CF seems to play a role in ACP recall and comprehension of IC for early-phase clinical trials, especially among older ACPs.

scholarly journals Moyamoya disease: functional and neurocognitive outcomes in the pediatric and adult populations

2011 ◽  
Vol 30 (6) ◽  
pp. E21 ◽  
Author(s):  
David G. Weinberg ◽  
Rudy J. Rahme ◽  
Salah G. Aoun ◽  
H. Hunt Batjer ◽  
Bernard R. Bendok
Keyword(s):  
Quality Of Life ◽  
Executive Function ◽  
Clinical Outcomes ◽  
Moyamoya Disease ◽  
Pediatric Patients ◽  
Adult Population ◽  
Cognitive Outcome ◽  
High Level ◽  
The Impact

Object Moyamoya disease is an occlusive cerebrovascular disorder commonly resulting in neurocognitive impairment. The cognitive outcome parameters commonly affected are intelligence, memory, executive function, and quality of life. In this paper, the authors review the existing literature on cognitive and clinical outcomes in adult and pediatric moyamoya populations separately. Methods A systematic review of the cognitive and clinical outcome literature was performed using the PubMed/MEDLINE database. Outcomes data were contrasted between adult and pediatric populations. Results Intelligence is the main cognitive outcome parameter affected in pediatric patients with moyamoya disease, whereas adults most commonly suffer from executive function impairment. Memory has not been studied sufficiently in pediatric patients, and its dysfunction in the adult population remains controversial. Quality of life has not been studied appropriately in either population. Surgical revascularization is the only beneficial treatment option, and a combination of direct and indirect bypass techniques has shown benefit, but the impact on the above-mentioned parameters has not been sufficiently elucidated. Conclusions Moyamoya disease affects the cognition and daily function in pediatric patients to a greater extent than in adult patients. Due to the rarity of the disease, there is a distinct lack of high-level evidence regarding cognitive and clinical outcomes.

scholarly journals Characteristics of Children Likely to Have Spontaneous Resolution of Obstructive Sleep Apnea: Results from the Childhood Adenotonsillectomy Trial (CHAT)

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 980
Author(s):  
Solveig Magnusdottir ◽  
Hugi Hilmisson ◽  
Roy J. E. M. Raymann ◽  
Manisha Witmans
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Executive Function ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Spontaneous Resolution ◽  
Healthy Weight ◽  
Simple Method ◽  
Obstructive Sleep

Objective: To evaluate if cardiopulmonary coupling (CPC) calculated sleep quality (SQI) may have a role in identifying children that may benefit from other intervention than early adenotonsillectomy (eAT) in management of obstructive sleep apnea (OSA). Methods: A secondary analysis of electrocardiogram-signals (ECG) and oxygen saturation-data (SpO2) collected during polysomnography-studies in the prospective multicenter Childhood Adenotonsillectomy Trial (CHAT) to calculate CPC-SQI and apnea hypopnea index (AHI) was executed. In the CHAT, children 5–9 years with OSA without prolonged oxyhemoglobin desaturations were randomly assigned to adenotonsillectomy (eAT) or watchful waiting with supportive care (WWSC). The primary outcomes were to document change in attention and executive function evaluated with the Developmental Neuropsychological Assessment (NEPSY). In our analysis, children in the WWSC-group with spontaneous resolution of OSA (AHIObstructive < 1.0) and high-sleep quality (SQI ≥ 75) after 7-months were compared with children that showed residual OSA. Results: Of the 227 children randomized to WWSC, 203 children had available data at both baseline and 7-month follow-up. The group that showed resolution of OSA at month 7 (n = 43, 21%) were significantly more likely to have high baseline SQI 79.96 [CI95% 75.05, 84.86] vs. 72.44 [CI95% 69.50, 75.39], p = 0.005, mild OSA AHIObstructive 4.01 [CI95% 2.34, 5.68] vs. 6.52 [CI95% 5.47, 7.57], p= 0.005, higher NEPSY-attention-executive function score 106.22 [CI95% 101.67, 110.77] vs. 101.14 [CI95% 98.58, 103.72], p = 0.038 and better quality of life according to parents 83.74 [CI95% 78.95, 88.54] vs. 77.51 [74.49, 80.53], p = 0.015. The groups did not differ when clinically evaluated by Mallampati score, Friedman palate position or sleep related questionnaires. Conclusions: Children that showed resolution of OSA were more likely to have high-SQI and mild OSA, be healthy-weight and have better attention and executive function and quality of life at baseline. As this simple method to evaluate sleep quality and OSA is based on analyzing signals that are simple to collect, the method is practical for sleep-testing, over multiple nights and on multiple occasions. This method may assist physicians and parents to determine the most appropriate therapy for their child as some children may benefit from WWSC rather than interventions. If the parameters can be used to plan care a priori, this would provide a fundamental shift in how childhood OSA is diagnosed and managed.

scholarly journals Executive Function Training in Childhood Obesity: Food Choice, Quality of Life, and Brain Connectivity (TOuCH): A Randomized Control Trial Protocol

2021 ◽  
Vol 9 ◽  
Author(s):  
Cristina Sanchez-Castañeda ◽  
Sandra Luis-Ruiz ◽  
Marta Ramon-Krauel ◽  
Carles Lerin ◽  
Consuelo Sanchez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Executive Function ◽  
Executive Functions ◽  
Neural Plasticity ◽  
Brain Plasticity ◽  
Trial Registration ◽  
Control Group ◽  
General Hypothesis ◽  
Executive Function Training

Background: Individuals with obesity are known to present cognitive deficits, especially in executive functions. Executive functions play an important role in health and success throughout the whole life and have been related to food decision-making and to the ability to maintain energy balance. It is possible to improve executive functions through targeted training. This would involve brain plasticity changes that could be studied through connectivity MRI. The general hypothesis of this study is that executive functions training in children with obesity can improve food choices and produce cognitive and neuroimaging changes (structural and functional connectivity), as well as improve emotional state and quality of life.Methods: Randomized controlled double-blind trial with 12-month follow-up. Thirty children with obesity will be randomly allocated into “executive training” (Cognifit with adaptive difficulty + Cogmed) or “control task” group (Cognifit without adaptive difficulty). Both groups will attend 30–45 min of individual gamified training (Cogmed and/or Cognifit systems) by iPad, five times per week during 6 weeks. Cogmed and Cognifit software are commercially available from Pearson and Cognifit, respectively. Participants will receive an iPad with both apps installed for a 6-week use. Participants will also receive counseling diet information via presentations sent to the iPad and will wear a Fitbit Flex 2 tracker to monitor daily activity and sleep patterns. Main outcomes will be cognitive, emotional, food decision, and quality-of-life measures, as well as neuroimaging measures. Participants are evaluated at baseline (T0), after treatment (T1), and 12 months since baseline (T2).Discussion: Longitudinal study with active control group and 3 time points: baseline, immediately after treatment, and 1 year after baseline. Threefold treatment: executive function training, psychoeducation, and feedback on activity/sleep tracking. We will evaluate the transfer effects of the intervention, including emotional and functional outcomes, as well as the effects on neural plasticity by connectivity MRI.Trial registration: This project has been registered in ClinicalTrials.gov (trial registration number NCT03615274), August 3, 2018.

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