A microcalcification cluster detection method based on deep learning and multi-scale feature fusion

2019 ◽  
Vol 75 (9) ◽  
pp. 5808-5830
Author(s):  
Xinsheng Zhang ◽  
Zhe Wang
Keyword(s):  
Deep Learning ◽  
Detection Method ◽  
Feature Fusion ◽  
Cluster Detection ◽  
Scale Feature ◽  
Multi Scale ◽  
Microcalcification Cluster

MUFFIN: multi-scale feature fusion for drug–drug interaction prediction

2021 ◽  
Author(s):  
Yujie Chen ◽  
Tengfei Ma ◽  
Xixi Yang ◽  
Jianmin Wang ◽  
Bosheng Song ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Deep Learning ◽  
Medical Information ◽  
Feature Fusion ◽  
Molecular Graph ◽  
Knowledge Graph ◽  
Sequence Information ◽  
Learning Models ◽  
Scale Feature ◽  
Multi Scale

Abstract Motivation Adverse drug–drug interactions (DDIs) are crucial for drug research and mainly cause morbidity and mortality. Thus, the identification of potential DDIs is essential for doctors, patients and the society. Existing traditional machine learning models rely heavily on handcraft features and lack generalization. Recently, the deep learning approaches that can automatically learn drug features from the molecular graph or drug-related network have improved the ability of computational models to predict unknown DDIs. However, previous works utilized large labeled data and merely considered the structure or sequence information of drugs without considering the relations or topological information between drug and other biomedical objects (e.g. gene, disease and pathway), or considered knowledge graph (KG) without considering the information from the drug molecular structure. Results Accordingly, to effectively explore the joint effect of drug molecular structure and semantic information of drugs in knowledge graph for DDI prediction, we propose a multi-scale feature fusion deep learning model named MUFFIN. MUFFIN can jointly learn the drug representation based on both the drug-self structure information and the KG with rich bio-medical information. In MUFFIN, we designed a bi-level cross strategy that includes cross- and scalar-level components to fuse multi-modal features well. MUFFIN can alleviate the restriction of limited labeled data on deep learning models by crossing the features learned from large-scale KG and drug molecular graph. We evaluated our approach on three datasets and three different tasks including binary-class, multi-class and multi-label DDI prediction tasks. The results showed that MUFFIN outperformed other state-of-the-art baselines. Availability and implementation The source code and data are available at https://github.com/xzenglab/MUFFIN.

scholarly journals 6mAPred-MSFF: A Deep Learning Model for Predicting DNA N6-Methyladenine Sites across Species Based on a Multi-Scale Feature Fusion Mechanism

2021 ◽  
Vol 11 (16) ◽  
pp. 7731
Author(s):  
Rao Zeng ◽  
Minghong Liao
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Prediction Accuracy ◽  
Cross Validation ◽  
Feature Fusion ◽  
Experimental Comparison ◽  
Scale Feature ◽  
Learning Framework ◽  
Multi Scale ◽  
Fold Cross Validation

DNA methylation is one of the most extensive epigenetic modifications. DNA N6-methyladenine (6mA) plays a key role in many biology regulation processes. An accurate and reliable genome-wide identification of 6mA sites is crucial for systematically understanding its biological functions. Some machine learning tools can identify 6mA sites, but their limited prediction accuracy and lack of robustness limit their usability in epigenetic studies, which implies the great need of developing new computational methods for this problem. In this paper, we developed a novel computational predictor, namely the 6mAPred-MSFF, which is a deep learning framework based on a multi-scale feature fusion mechanism to identify 6mA sites across different species. In the predictor, we integrate the inverted residual block and multi-scale attention mechanism to build lightweight and deep neural networks. As compared to existing predictors using traditional machine learning, our deep learning framework needs no prior knowledge of 6mA or manually crafted sequence features and sufficiently capture better characteristics of 6mA sites. By benchmarking comparison, our deep learning method outperforms the state-of-the-art methods on the 5-fold cross-validation test on the seven datasets of six species, demonstrating that the proposed 6mAPred-MSFF is more effective and generic. Specifically, our proposed 6mAPred-MSFF gives the sensitivity and specificity of the 5-fold cross-validation on the 6mA-rice-Lv dataset as 97.88% and 94.64%, respectively. Our model trained with the rice data predicts well the 6mA sites of other five species: Arabidopsis thaliana, Fragaria vesca, Rosa chinensis, Homo sapiens, and Drosophila melanogaster with a prediction accuracy 98.51%, 93.02%, and 91.53%, respectively. Moreover, via experimental comparison, we explored performance impact by training and testing our proposed model under different encoding schemes and feature descriptors.

scholarly journals Adaptive Weighted Multi-Level Fusion of Multi-Scale Features: A New Approach to Pedestrian Detection

2021 ◽  
Vol 13 (2) ◽  
pp. 38
Author(s):  
Yao Xu ◽  
Qin Yu
Keyword(s):  
Deep Learning ◽  
Feature Fusion ◽  
Pedestrian Detection ◽  
Feature Maps ◽  
Scale Feature ◽  
Multi Scale ◽  
One Stage ◽  
Current State ◽  
Multi Level ◽  
Feature Utilization

Great achievements have been made in pedestrian detection through deep learning. For detectors based on deep learning, making better use of features has become the key to their detection effect. While current pedestrian detectors have made efforts in feature utilization to improve their detection performance, the feature utilization is still inadequate. To solve the problem of inadequate feature utilization, we proposed the Multi-Level Feature Fusion Module (MFFM) and its Multi-Scale Feature Fusion Unit (MFFU) sub-module, which connect feature maps of the same scale and different scales by using horizontal and vertical connections and shortcut structures. All of these connections are accompanied by weights that can be learned; thus, they can be used as adaptive multi-level and multi-scale feature fusion modules to fuse the best features. Then, we built a complete pedestrian detector, the Adaptive Feature Fusion Detector (AFFDet), which is an anchor-free one-stage pedestrian detector that can make full use of features for detection. As a result, compared with other methods, our method has better performance on the challenging Caltech Pedestrian Detection Benchmark (Caltech) and has quite competitive speed. It is the current state-of-the-art one-stage pedestrian detection method.

scholarly journals Infrared small target detection method based on multi-scale feature fusion

2021 ◽  
Vol 2024 (1) ◽  
pp. 012012
Author(s):  
Fang Wang ◽  
Chuanqiang Li ◽  
Bo Wu ◽  
Kun Yu ◽  
Chan Jin
Keyword(s):  
Target Detection ◽  
Detection Method ◽  
Feature Fusion ◽  
Small Target ◽  
Scale Feature ◽  
Small Target Detection ◽  
Multi Scale ◽  
Infrared Small Target
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