Pharmacogenetic distribution of warfarin and its clinical significance in Korean patients during initial anticoagulation therapy

2011 ◽  
Vol 32 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Aerin Kwon ◽  
Sang-Ho Jo ◽  
Hyoung-June Im ◽  
Yun-A Jo ◽  
Ji-Young Park ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Anticoagulation Therapy ◽  
Korean Patients

scholarly journals Trends in Oral Anticoagulation Therapy Among Korean Patients With Atrial Fibrillation: The KORean Atrial Fibrillation Investigation

2012 ◽  
Vol 42 (2) ◽  
pp. 113 ◽  
Author(s):  
Hong-Won Shin ◽  
Yoon-Nyun Kim ◽  
Han-Jun Bae ◽  
Ho-Myung Lee ◽  
Hyun-Ok Cho ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Oral Anticoagulation ◽  
Anticoagulation Therapy ◽  
Oral Anticoagulation Therapy ◽  
Korean Patients

High frequency ofJAK2exon 12 mutations in Korean patients with polycythaemia vera: novel mutations and clinical significance

2016 ◽  
Vol 69 (8) ◽  
pp. 737-741 ◽  
Author(s):  
Chang-Hun Park ◽  
Ki-O Lee ◽  
Jun-Ho Jang ◽  
Chul Won Jung ◽  
Jong-Won Kim ◽  
...  
Keyword(s):  
Clinical Significance ◽  
High Frequency ◽  
Polycythaemia Vera ◽  
Novel Mutations ◽  
Korean Patients

The Prevalence and Clinical Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Korean Patients with Ulcerative Colitis

2009 ◽  
Vol 55 (5) ◽  
pp. 1406-1412 ◽  
Author(s):  
Jin Ha Lee ◽  
Jae Hee Cheon ◽  
Eun Soo Kim ◽  
Moon Jae Chung ◽  
Wonseok Kang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Significance ◽  
Korean Patients

Clinical Significance of Genetic Variations in the PI3K/PTEN/AKT/mTOR Pathway in Korean Patients with Colorectal Cancer

Oncology ◽  
2010 ◽  
Vol 79 (3-4) ◽  
pp. 278-282 ◽  
Author(s):  
Jong Gwang Kim ◽  
Yee Soo Chae ◽  
Sang Kyun Sohn ◽  
Byung Woog Kang ◽  
Joon Ho Moon ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Genetic Variations ◽  
Mtor Pathway ◽  
Korean Patients

scholarly journals Clinical Significance of Hematuria in Atrial Fibrillation With Oral Anticoagulation Therapy

2017 ◽  
Vol 81 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Hee Tae Yu ◽  
Tae-Hoon Kim ◽  
Jae-Sun Uhm ◽  
Jong-Youn Kim ◽  
Hui-Nam Pak ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Significance ◽  
Oral Anticoagulation ◽  
Anticoagulation Therapy ◽  
Oral Anticoagulation Therapy

scholarly journals The Clinical Significance of Drug–Food Interactions of Direct Oral Anticoagulants

2021 ◽  
Vol 22 (16) ◽  
pp. 8531
Author(s):  
Grzegorz Grześk ◽  
Daniel Rogowicz ◽  
Łukasz Wołowiec ◽  
Agnieszka Ratajczak ◽  
Wojciech Gilewski ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Clinical Significance ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Healthcare Providers ◽  
Anticoagulation Therapy ◽  
Daily Practice ◽  
Food Ingredients ◽  
Clinical Observations

Cardiovascular diseases are the most common cause of death in the world. For almost 60 years, vitamin K antagonists (VKAs) were the mainstay of anticoagulation therapy, but in recent years direct oral anticoagulants (DOACs) have become the anticoagulant treatment of choice. DOACs were initially considered drugs with no significant food interactions; however, clinical observations from daily practice have proved otherwise as interactions with food ingredients have been reported. Food, dietary supplements or herbs may contain substances that, when administered concomitantly with DOACs, can potentially affect the plasma concentration of the drugs. The aim of this paper was to evaluate the clinical significance of drug–food interactions of DOACs, such as dabigatran, rivaroxaban, apixaban, edoxaban and betrixaban. Patients treated with anticoagulants should avoid products containing St. John’s wort and take special care with other food ingredients. As the interest in dietary supplements is on the rise, healthcare providers can contribute to the development of well-designed clinical trials on interactions between DOACs and food, and distribute sufficient knowledge about the proper use of these supplements among patients.

scholarly journals Prevalence, Clinical Characteristics, and Predictors of Patients with Thromboembolic Events in Takotsubo Cardiomyopathy

2016 ◽  
Vol 10 ◽  
pp. CMC.S38151 ◽  
Author(s):  
Ibrahim El-Battrawy ◽  
Michael Behnes ◽  
Dennis Hillenbrand ◽  
Darius Haghi ◽  
Ursula Hoffmann ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Clinical Significance ◽  
Takotsubo Cardiomyopathy ◽  
Clinical Characteristics ◽  
Anticoagulation Therapy ◽  
Thromboembolic Events ◽  
St Segment Elevation ◽  
Reactive Protein ◽  
Kaplan Meier ◽  
St Segment

Background Several acute complications related to takotsubo cardiomyopathy (TTC) have been documented recently. However, the incidence and clinical significance of acute thromboembolic events in TTC is not well established. Methods A detailed investigation of the clinical characteristics and in-hospital complications of 114 consecutive patients diagnosed with TTC between January 2003 and September 2015 was carried out. This study was initiated to reveal the predictors, clinical significance, and short-term and long-term outcomes of patients with TTC associated with acute thromboembolic events on index presentation. Results The incidence of acute thromboembolic events related to TTC was around 12.2%, and these included ventricular thrombi, cerebrovascular events, retinal and brachial artery pathologies, renal, splenic, and aortic involvement. The most frequent complication on initial presentation was cardiogenic shock (20%) accompanied with pulmonary congestion (20%). Interestingly, patients experiencing thromboembolic events had higher C-reactive protein (CRP) levels as compared to the non-thromboembolic group ( P = 0.02). Certain thromboembolic events were characterized by the presence of ST-segment elevation in electrocardiogram ( P 0.02). Chest pain was the primary symptom in these patients ( P 0.09). Furthermore, there was significant right ventricular involvement (as assessed by transthoracic echocardiography) in patients presenting with an acute thromboembolic event ( P 0.08). A Kaplan–Meier analysis indicated a significantly higher mortality rate over a mean follow-up of three years in the thromboembolic group than the non-thromboembolic group (log-rank, P = 0.02). Conclusions Our results confirmed the relative common occurrence of thromboembolic events in the setting of TTC. Inflammation might play an important role in the development of thromboembolic events, and a right ventricular involvement and ST-segment elevation could be positive predictors for this occurrence. In order to circumvent the risk of a negative outcome, it is recommended that an anticoagulation therapy be initiated in all high-risk patients.

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