scholarly journals Amide proton transfer imaging in differentiation of type II and type I endometrial carcinoma: a pilot study

2021 ◽  
Author(s):  
Ryoya Ochiai ◽  
Naoko Mukuda ◽  
Hiroto Yunaga ◽  
Shinichiro Kitao ◽  
Kyohei Okuda ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Endometrial Carcinoma ◽  
Sensitivity And Specificity ◽  
Amide Proton ◽  
Magnetization Transfer Ratio ◽  
Type I ◽  
Type Ii ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
Significant Difference

Abstract Purpose This study aimed at evaluating the efficacy of amide proton transfer (APT) imaging in differentiation of type II and type I uterine endometrial carcinoma. Materials and methods Thirty-three patients diagnosed with uterine endometrial carcinoma, including 24 with type I and 9 with type II carcinomas, underwent APT imaging. Two readers evaluated the magnetization transfer ratio at 3.5 ppm [MTRasym (3.5 ppm)] in each type of carcinoma. The average MTRasym (APTmean) and the maximum MTRasym (APTmax) were analyzed. The receiver operating characteristic (ROC) curve analysis was performed. Results The APTmax was significantly higher in type II carcinomas than in type I carcinomas (reader1, p = 0.004; reader 2, p = 0.014; respectively). However, APTmean showed no significant difference between type I and II carcinomas. Based on the results reported by reader 1, the area under the curve (AUC) pertaining to the APTmax for distinguishing type I from type II carcinomas was 0.826, with a cut-off, sensitivity, and specificity of 9.90%, 66.7%, and 91.3%, respectively. Moreover, based on the results reported by reader 2, the AUC was 0.750, with a cut-off, sensitivity, and specificity of 9.80%, 62.5%, and 87.5%, respectively. Conclusion APT imaging has the potential to determine the type of endometrial cancer.

scholarly journals Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77019 ◽  
Author(s):  
Osamu Togao ◽  
Chase W. Kessinger ◽  
Gang Huang ◽  
Todd C. Soesbe ◽  
Koji Sagiyama ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mouse Model ◽  
Proton Transfer ◽  
In Vivo Study ◽  
Amide Proton ◽  
Orthotopic Mouse Model ◽  
Amide Proton Transfer ◽  
Apt Imaging

Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors

2020 ◽  
Vol 129 ◽  
pp. 109047 ◽  
Author(s):  
Takeshi Kamitani ◽  
Koji Sagiyama ◽  
Osamu Togao ◽  
Yuzo Yamasaki ◽  
Tomoyuki Hida ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Amide Proton ◽  
Benign Tumors ◽  
Amide Proton Transfer ◽  
Parotid Tumors ◽  
Apt Imaging ◽  
Malignant And Benign Tumors

Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T1-Relaxation properties

2016 ◽  
Vol 77 (4) ◽  
pp. 1525-1532 ◽  
Author(s):  
Vitaliy Khlebnikov ◽  
Daniel Polders ◽  
Jeroen Hendrikse ◽  
Pierre A. Robe ◽  
Eduard H. Voormolen ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Proton Transfer ◽  
Amide Proton ◽  
Tissue Water ◽  
Relaxation Properties ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
T1 Relaxation

scholarly journals Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging

2008 ◽  
Vol 60 (4) ◽  
pp. 842-849 ◽  
Author(s):  
Jinyuan Zhou ◽  
Jaishri O. Blakeley ◽  
Jun Hua ◽  
Mina Kim ◽  
John Laterra ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Proton Transfer ◽  
Human Brain ◽  
Data Acquisition ◽  
Amide Proton ◽  
Human Brain Tumor ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
Acquisition Method

scholarly journals Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke

2008 ◽  
Vol 59 (5) ◽  
pp. 1175-1182 ◽  
Author(s):  
Phillip Zhe Sun ◽  
Yoshihiro Murata ◽  
Jie Lu ◽  
Xiaoying Wang ◽  
Eng H. Lo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Proton Transfer ◽  
Acute Ischemic Stroke ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Apt Imaging

scholarly journals Amide Proton Transfer-Weighted (APTw) Imaging of Intracranial Infection in Children: Initial Experience and Comparison with Gadolinium-Enhanced T1-Weighted Imaging

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Hong Zhang ◽  
Xiaolu Tang ◽  
Yanqiu Lv ◽  
Di Hu ◽  
Jihang Sun ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Predictive Value ◽  
Amide Proton ◽  
High Signal ◽  
Noninvasive Technique ◽  
Intracranial Infection ◽  
Amide Proton Transfer ◽  
Significant Difference ◽  
Sensitivity Specificity ◽  
Age Range

Purpose. To evaluate the performance of amide proton transfer-weighted (APTw) imaging against the reference standard of gadolinium-enhanced T1-weighted imaging (Gd-T1w) in children with intracranial infection. Materials and Methods. Twenty-eight pediatric patients (15 males and 13 females; age range 1-163 months) with intracranial infection were recruited in this study. 2D APTw imaging and conventional MR sequences were conducted using a 3 T MRI scanner. Kappa (κ) statistics and the McNemar test were performed to determine whether the hyperintensity on APTw was related to the enhancement on Gd-T1w. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of APTw imaging to predict lesion enhancement were calculated. Result. In twelve patients with brain abscesses, the enhancing rim of the abscesses on the Gd-T1w images was consistently hyperintense on the APTw images. In eight patients with viral encephalitis, three showed slight spotted gadolinium enhancement, while the APTw image also showed a slight spotted high signal. Five of these patients showed no enhancement on Gd-T1w and isointensity on the APTw image. In eleven patients with meningitis, increased APTw signal intensities were clearly visible in gadolinium-enhancing meninges. Sixty infectious lesions (71%) showed enhancement on Gd-T1w images. The sensitivity and specificity of APTw were 93.3% (56/60) and 91.7% (22/24). APTw demonstrated excellent agreement (κ=0.83) with Gd-T1w, with no significant difference (P=0.69) in detection of infectious lesions. Conclusions. These initial data show that APTw MRI is a noninvasive technique for the detection and characterization of intracranial infectious lesions. APTw MRI enabled similar detection of infectious lesions to Gd-T1w and may provide an injection-free means of evaluation of intracranial infection.

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