:
Thymoquinone (TQ) is one of the leading phytochemicals, which is abundantly found in Nigella sativa L.
seeds. TQ exhibited various biological effects such as antioxidant, anti-inflammatory, antimicrobial, and anti-tumoral in
several pre-clinical studies. Parkinson's disease (PD) is a long-term neurodegenerative disease with movement difficulties,
and the common feature of neurodegeneration in PD patients is caused by dopaminergic neural damage in the substantia
nigra pars compacta. The neuroprotective activity of TQ has been studied in various neurological disorders. TQ-mediated
neuroprotection against PD yet to be reported in a single frame; therefore, this review is intended to narrate the
potentiality of TQ in the therapy of PD. TQ has been shown to protect against neurotoxins via amelioration of
neuroinflammation, oxidative stress, apoptosis, thereby protects neurodegeneration in PD models. TQ could be an
emerging therapeutic intervention in PD management, but mechanistic studies have been remained to be investigated to
clarify its neuroprotective role.