Psychosocial, Lifestyle, and Body Weight Impact of COVID-19-Related Lockdown in a Sample of Participants with Current or Past History of Obesity in Spain

Obesity is a serious condition that can cause emotional and social problems. A person is considered overweight if his weight is 10% to 20% over his ideal body weight, while obesity occurs when a person has more than 20% over his ideal body weight. The working area of the Community Health Center (Puskesmas) of SuakRibeewas the area with the highest incidence of obesity in West Aceh with 89 cases. This study aims to find out the relationship between the incidenceof obesity and the factor of knowledge, diet, physical activity, family history of obesity, and occupation. This study is an analytical study with cross-sectional design. The sample in this study was all women of reproductive age in the working area ofPuskesmas of SuakRibee of Johan Pahlawan District of West Aceh Regency. The sample was taken using cluster sampling method, with a total of 98 people. The data analysis technique used was correlation test. Based on the results of the correlation test,it can be concluded that there was no relationship between the incidence of obesity and knowledge (p-value = 0.113> α = 0.05).However, there was a relationship between the incidence of obesity and diet (p-value = 0.030 <α = 0.05); physical activity (p-value = 0.021 <α = 0.05); family history of obesity (p-value = 0.034 <α = 0.05);and occupation (p-value = 0.000 <α = 0.05).

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Parental obesity programs pancreatic cancer development in offspring

Endocrine Related Cancer ◽

10.1530/erc-19-0016 ◽

2019 ◽

Vol 26 (5) ◽

pp. 511-523 ◽

Cited By ~ 5

Author(s):

Raquel Santana da Cruz ◽

Johan Clarke ◽

Ana Cristina P Curi ◽

Aseel Al-Yawar ◽

Lu Jin ◽

...

Keyword(s):

Pancreatic Cancer ◽

Body Weight ◽

Control Diet ◽

Epidemiological Studies ◽

Cancer Development ◽

Separate Experiment ◽

Metabolic Dysfunction ◽

History Of ◽

History Of Obesity ◽

The Impact

Epidemiological studies suggest that timing of obesity onset – and underlying metabolic dysfunction – is important in determining pancreatic cancer rates: early and young adult abdominal overweight/obesity is more strongly associated with this cancer than obesity that develops later in life. Parental obesity and overweight are associated with metabolic dysfunction and obesity in their children. Here, we evaluated the impact of parental overweight on offspring’s susceptibility of pancreatic cancer using the P48Cre/+/KrasG12D/+ mouse model. Male mice were fed an obesity-inducing diet (OID) before conception and mated with females raised on a control diet (CO) to generate the offspring. In a separate experiment, pregnant dams were fed CO or OID throughout gestation. The resulting OID offspring from the maternal (OID-m) or paternal lineage (OID-p) were used to study body weight, metabolic parameters and pancreatic cancer development and for molecular analysis. Parental obesity increased offspring’s body weight at birth, weaning and in adulthood compared to CO, with gender- and genotype-specific differences. OID-p and OID-m offspring showed metabolic disorder and accelerated development of high-grade PanIN/PDAC. OID offspring also had higher rates of acinar-to-ductal reprogramming assessed by CPA1+/SOX9+-positive pancreatic cells. Levels of Tenascin C (TNC), an ECM glycoprotein shown to suppress apoptosis, were elevated in OID offspring, particularly females. In line with that, OID offspring displayed increased collagen content and decreased apoptosis in pancreatic lesions compared to CO. An ancestral history of obesity through either the paternal or maternal lineages increases offspring’s susceptibility to pancreatic cancer development.

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Bilateral Glomus Jugularae Paragangliomas Treated with Fractionated Stereotactic Intensity-Modulated Radiotherapy in a Patient with Past History of Bilateral Carotid Body Tumors

Skull Base ◽

10.1055/s-2007-981807 ◽

2007 ◽

Vol 17 (S 2) ◽

Author(s):

Edward Melian ◽

John Leonetti ◽

Elke Aippersbach ◽

Anil Sethi ◽

Douglas Anderson ◽

...

Keyword(s):

Carotid Body ◽

Past History ◽

Intensity Modulated Radiotherapy ◽

Intensity Modulated ◽

Bilateral Carotid ◽

History Of ◽

Carotid Body Tumors

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PREVALENCE AND RELATED FACTORS OF POSTNATAL DEPRESSION IN HIV INFECTED WOMEN

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.20 ◽

2014 ◽

pp. 140-152

Author(s):

Manh Hoan Nguyen ◽

Ngoc Thanh Cao

Keyword(s):

Regression Analysis ◽

Postpartum Depression ◽

Hiv Infection ◽

Postnatal Depression ◽

Past History ◽

Depression Scale ◽

Multivariate Regression Analysis ◽

Related Factors ◽

History Of ◽

History Of Depression

Background and Objective: HIV infection is also a cause of postpartum depression, however, in Vietnam, there has not yet the prevalence of postpartum depression in HIV infected women. The objective is to determine prevalence and related factors of postpartum depression in HIV infected women. Materials and Methods: From November 30th, 2012 to March 30th, 2014, a prospective cohort study is done at Dong Nai and Binh Duong province. The sample includes135 HIV infected women and 405 non infected women (ratio 1/3) who accepted to participate to the research. We used “Edinburgh Postnatal Depression Scale (EPDS) as a screening test when women hospitalized for delivery and 1 week, 6weeks postpartum. Mother who score EPDS ≥ 13 are likely to be suffering from depression. We exclude women who have EPDS ≥ 13 since just hospitalize. Data are collected by a structural questionaire. Results: At 6 weeks postpartum, prevalence of depression in HIV infected women is 61%, in the HIV non infected women is 8.7% (p < 0.001). There are statistical significant differences (p<0.05) between two groups for some factors: education, profession, income, past history of depression, child’s health, breast feeding. Logistical regression analysis determine these factors are related with depression: late diagnosis of HIV infection, child infected of HIV, feeling guilty of HIV infected and feeling guilty with their family. Multivariate regression analysis showed 4 factors are related with depression: HIV infection, living in the province, child’s health, past history of depression. Conclusion: Prevalence of postpartum depression in HIV infected women is 61.2%; risk of depression of postnatal HIV infected women is 6.4 times the risk of postnatal HIV non infected women, RR=6.4 (95% CI:4.3 – 9.4). Domestic women have lower risk than immigrant women from other province, RR=0.72 (95% CI:0.5 – 0.9). Past history of depression is a risk factor with RR=1.7 (95% CI:1.02 – 0.9. Women whose child is weak or die, RR=1.7(95% CI:0.9 – 3.1). Keywords: Postpartum depression, HIV-positive postpartum women

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Nonlocal Gravity

10.1093/oso/9780198803805.001.0001 ◽

2017 ◽

Cited By ~ 5

Author(s):

Bahram Mashhoon

Keyword(s):

Gravitational Field ◽

Gravitational Lensing ◽

Past History ◽

Lorentz Invariance ◽

Minkowski Spacetime ◽

Field Measurements ◽

Local Principle ◽

History Of ◽

Expansion Of The Universe ◽

Nearby Galaxies

A postulate of locality permeates through the special and general theories of relativity. First, Lorentz invariance is extended in a pointwise manner to actual, namely, accelerated observers in Minkowski spacetime. This hypothesis of locality is then employed crucially in Einstein’s local principle of equivalence to render observers pointwise inertial in a gravitational field. Field measurements are intrinsically nonlocal, however. To go beyond the locality postulate in Minkowski spacetime, the past history of the accelerated observer must be taken into account in accordance with the Bohr-Rosenfeld principle. The observer in general carries the memory of its past acceleration. The deep connection between inertia and gravitation suggests that gravity could be nonlocal as well and in nonlocal gravity the fading gravitational memory of past events must then be taken into account. Along this line of thought, a classical nonlocal generalization of Einstein’s theory of gravitation has recently been developed. In this nonlocal gravity (NLG) theory, the gravitational field is local, but satisfies a partial integro-differential field equation. A significant observational consequence of this theory is that the nonlocal aspect of gravity appears to simulate dark matter. The implications of NLG are explored in this book for gravitational lensing, gravitational radiation, the gravitational physics of the Solar System and the internal dynamics of nearby galaxies as well as clusters of galaxies. This approach is extended to nonlocal Newtonian cosmology, where the attraction of gravity fades with the expansion of the universe. Thus far only some of the consequences of NLG have been compared with observation.

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The vicious cycle: a history of obesity and COVID-19

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02134-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jacek Bil ◽

Olga Możeńska

Keyword(s):

Enzyme Inhibitors ◽

Angiotensin Converting Enzyme Inhibitors ◽

Obesity Paradox ◽

Lifestyle Changes ◽

Angiotensin Ii Receptor ◽

Converting Enzyme Inhibitors ◽

History Of ◽

Receptor Blockers ◽

History Of Obesity

AbstractRecently, we face a surge in the fast-forward Coronavirus Disease 2019 (COVID-19) pandemic with nearly 170 million confirmed cases and almost 3.5 million confirmed deaths at the end of May 2021. Obesity, also known as the pandemic of the 21st century, has been evolving as an adverse prognostic marker. Obesity is associated with a higher risk of being SARS-CoV-2-positive (46%), as well as hospitalization (113%) and death (48%) due to COVID-19. It is especially true for subjects with morbid obesity. Also, observational studies suggest that in the case of COVID-19, no favorable “obesity paradox” is observed. Therefore, it is postulated to introduce a new entity, i.e., coronavirus disease-related cardiometabolic syndrome (CIRCS). In theory, it applies to all stages of COVID-19, i.e., prevention, acute proceedings (from COVID-19 diagnosis to resolution or three months), and long-term outcomes. Consequently, lifestyle changes, glycemic control, and regulation of the renin-angiotensin-aldosterone pathway have crucial implications for preventing and managing subjects with COVID-19. Finally, it is crucial to use cardioprotective drugs such as angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers and statins. Nevertheless, there is the need to conduct prospective studies and registries better to evaluate the issue of obesity in COVID-19 patients.

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Insulin Dosage Adjustments After Initiation of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes

Journal of Pharmacy Practice ◽

10.1177/0897190021993625 ◽

2021 ◽

pp. 089719002199362

Author(s):

Mandy Chen ◽

Etty Vider ◽

Roda Plakogiannis

Keyword(s):

Type 2 Diabetes ◽

Body Weight ◽

Insulin Therapy ◽

Basal Insulin ◽

Insulin Dose ◽

Retrospective Chart Review ◽

Insulin Dosage ◽

History Of ◽

Bolus Insulin

Background: Combination of insulin and GLP-1RAs have shown reductions in the HbA1c, body weight, and the risk of hypoglycemia. To date, there are conflicting data regarding the effect of GLP-1RAs on insulin dosage(s). Objective: The objective of this study was to evaluate adjustments of insulin doses upon initiation of GLP-1RAs. Methods: This was a retrospective chart review of patients on insulin therapy initiated on GLP-1RAs at NYU Langone Health. Patients were included in the study if they were at least 18 years of age, history of type 2 diabetes, and were on concurrent basal or mixed insulin therapy. 45 patients met inclusion criteria and were included in the study analysis. The primary endpoint was the median change in overall basal insulin doses. Secondary endpoints included median changes in total basal, mixed, and bolus insulin doses, oral antidiabetic medications and GLP-1RA doses, HbA1c, body weight, fasting glucose, and creatinine clearance. Safety results included any adverse reactions to insulin and/or GLP-1RA. Results: In the per-protocol analysis, there was a significant reduction in overall total basal insulin doses from baseline to week 24 (50 units vs. 44 units, p < 0.05). There was a median reduction in patients receiving glargine (50 units vs. 44 units) and detemir (29 units vs. 21.5 units). Conclusions: Use of GLP-1RAs after 24 weeks resulted in a statistically significant reduction in overall total basal insulin dosages from baseline. The median HbA1C in our patient population was >8%. Consider a ≥10% reduction in the overall basal insulin dose upon initiation of GLP-1RA in patients with a HbA1C >8%.

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Do Deeper Levels of Cervical Biopsies Preceded by a Pap Smear Diagnosis of LSIL, ASCUS, or NILM/HPV+ Increase the Yield of Identifying Clinically Significant Lesions?

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqaa161.356 ◽

2020 ◽

Vol 154 (Supplement_1) ◽

pp. S163-S164

Author(s):

K G Manjee ◽

W G Watkin

Keyword(s):

Pap Smear ◽

Past History ◽

Prior History ◽

Cervical Biopsy ◽

P16 Immunohistochemistry ◽

Hpv Status ◽

Significant Difference ◽

History Of ◽

Clinically Significant ◽

Almost All

Abstract Introduction/Objective Cervical biopsy is performed following an abnormal pap smear or positive HPV testing in an attempt to uncover clinically significant lesions [HSIL/invasive carcinoma (HSIL+)]. An excisional procedure is considered if biopsy confirms HSIL+. When preceded by pap smear of LSIL, ASCUS, NILM/HPV+ or persistent HPV, continued surveillance is recommended for biopsies showing no SIL or LSIL. In our laboratory, cervical biopsies are routinely sectioned at 3 levels. Deeper levels are often ordered when initial sections are non-diagnostic. p16 immunohistochemistry, with or without deeper levels, is often ordered to confirm HSIL, or to differentiate HSIL from mimics. In this study, we examine whether and in what clinical situations does obtaining additional levels uncover clinically significant lesions. Methods 430 cervical biopsies between January-May 2018, with recent cytology of LSIL, ASCUS or NILM/HPV+ were identified in the pathology database. HPV status (if known), final biopsy diagnosis and past history of LSIL/HSIL were recorded. For each biopsy, orders for additional levels and/or p16 immunohistochemistry were recorded resulting in 4 categories: C1-no additional levels or p16, C2-deeper only, C3-deeper+p16 and C4-p16 only. Final diagnoses were divided into HSIL+, LSIL and no SIL. Results There was no significant difference in prior history of LSIL/HSIL and HPV status between all categories. Biopsy results were as follows: HSIL+: 11/222 (5%) C1; 1/78 (1%) C2; 7/43 (16%) C3; 15/87 (17%) C4 LSIL: 91/222 (41%) C1; 7/78 (9%) C2; 16/43 (37%) C3; 35/87 (40%) C4 No SIL: 120/222 (54%) C1; 70/78 (90%) C2; 20/43 (46%) C3; 37/87 (42%) C4 The average number of additional levels in C2 and C3 was 3.8 and 1.8, respectively. Conclusion Deeper levels alone did not enhance the detection of HSIL+. Almost all LSIL/HSIL were detected when initial levels were diagnostic or suspicious and supported by p16 immunohistochemistry. 3 levels are adequate to detect clinically significant lesions.

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Tapering body stiffness shortens upper gastrointestinal examination via transoral insertion with ultrathin endoscope

Endoscopy International Open ◽

10.1055/a-1266-3203 ◽

2020 ◽

Vol 08 (12) ◽

pp. E1748-E1753

Author(s):

Satoshi Ono ◽

Shun Ito ◽

Kyohei Maejima ◽

Shosuke Hosaka ◽

Kiyotaka Umeki ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Past History ◽

Insertion Time ◽

Trade Off ◽

Examination Time ◽

Total Examination Time ◽

History Of ◽

Food Residues ◽

Gastrointestinal Examination ◽

Upper Gastrointestinal

Abstract Background and study aims Ultrathin endoscopes are commonly used for surveillance esophagogastroduodenoscopy (EGD) to reduce discomfort associated with scope insertion. However, the flexibility of an ultrathin endoscope is a trade-off between reducing discomfort and lengthening examination time. Patients and methods The EG17-J10 (EG17) is a novel ultrathin endoscope characterized by its tapering body stiffness; however, the flexibility of its tip is comparable to that of the traditional ultrathin endoscope EG16-K10 (EG16). We compared EGD examination time between EG17 and EG16. A total of 319 examinees who underwent EGD from November 2019 to January 2020 at the Chiba-Nishi General Hospital were enrolled. Six examinees were excluded due to past history of surgical resection of the upper gastrointestinal tract or too much food residues; 313 examinees (EG17, 209; EG16,104) were retrospectively analyzed. The examination time was divided into three periods: esophageal insertion time (ET), gastroduodenal insertion time (GDT), and surveillance time of the stomach (ST). The total amount of ET, GDT, and ST was defined as total examination time (TT). Results TT of EGD using EG17 was significantly shorter compared to EGD using EG16 (222.7 ± 68.9 vs. 245.7 ± 78.5 seconds) (P = 0.004). Among the three periods of examination time, ET (66.7 ± 24.1 vs. 76.0 ± 24.1 seconds) (P = 0.001) and GDT (47.9 ± 17.4 vs. 55.2 ± 35.2 seconds) (P = 0.007) of EGD using EG17 were significantly shorter compared to EGD using EG16, except for ST (108.1 ± 51.5.1 vs. 114.5 ± 50.1 seconds) (P = 0.148). Conclusion An ultrathin endoscope with tapering body stiffness can shorten EGD examination time, mainly due to the shortening of insertion time.

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