Effect of Everolimus on Heterogenous Renal Cancer Cells Populations Including Renal Cancer Stem Cells

Renal cell carcinoma (RCC) is a major neoplasm with high incidence in western countries. Tumors are heterogeneous and are composed of differentiated cancer cells, stromal cells, and cancer stem cells (CSCs). CSCs possess two main properties: self-renewal and proliferation. Additionally, they can generate new tumors once transplanted into immunodeficient mice. Several approaches have been described to identify them, through the expression of cell markers, functional assays, or a combination of both. As CSCs are involved in the resistance mechanisms to radio- and chemotherapies, several new strategies have been proposed to directly target CSCs in RCC. One approach drives CSCs to differentiate into cancer cells sensitive to conventional treatments, while the other proposes to eradicate them selectively. A series of innovative therapies aiming at eliminating CSCs have been designed to treat other types of cancer and have not been experimented with on RCC yet, but they reveal themselves to be promising. In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients.

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Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

Cancer Research ◽

10.1158/0008-5472.can-11-0241 ◽

2011 ◽

Vol 71 (15) ◽

pp. 5346-5356 ◽

Cited By ~ 528

Author(s):

Cristina Grange ◽

Marta Tapparo ◽

Federica Collino ◽

Loriana Vitillo ◽

Christian Damasco ◽

...

Keyword(s):

Stem Cells ◽

Cancer Stem Cells ◽

Renal Cancer ◽

Premetastatic Niche ◽

Renal Cancer Stem Cells

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MP067MICRORNA PROFILING USING NEXT-GENERATION SEQUENCING IN RENAL CANCER STEM CELLS: A NEW REGULATORY MECHANISM

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx162.mp067 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii450-iii450

Author(s):

Grazia Serino ◽

Fabio Sallustio ◽

Vanessa Galleggiante ◽

Monica Rutigliano ◽

Claudia Curci ◽

...

Keyword(s):

Stem Cells ◽

Next Generation Sequencing ◽

Cancer Stem Cells ◽

Renal Cancer ◽

Regulatory Mechanism ◽

Next Generation ◽

Renal Cancer Stem Cells ◽

Generation Sequencing

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Targeting Strategies for Renal Cancer Stem Cell Therapy

Current Pharmaceutical Design ◽

10.2174/1381612826666200318153106 ◽

2020 ◽

Vol 26 (17) ◽

pp. 1964-1978 ◽

Cited By ~ 1

Author(s):

Pengchao Fang ◽

Liuting Zhou ◽

Lee Y. Lim ◽

Hualin Fu ◽

Zhi-xiang Yuan ◽

...

Keyword(s):

Stem Cells ◽

Renal Cell Carcinoma ◽

Stem Cell ◽

Targeted Therapy ◽

Cancer Stem Cells ◽

Renal Cancer ◽

Treatment Resistance ◽

Treatment Efficiency ◽

Renal Carcinogenesis ◽

Renal Cancer Stem Cells

Renal cell carcinoma (RCC) is an intractable genitourinary malignancy that accounts for approximately 4% of adult malignancies. Currently, there is no approved targeted therapy for RCC that has yielded durable remissions, and they remain palliative in intent. Emerging evidence has indicated that renal tumorigenesis and RCC treatment-resistance may originate from renal cancer stem cells (CSCs) with tumor-initiating capacity (CSC hypothesis). A better understanding of the mechanism underlying renal CSCs will help to dissect RCC heterogeneity and drug treatment efficiency, to promote more personalized and targeted therapies. In this review, we summarized the stem cell characteristics of renal CSCs. We outlined the targeting strategies and challenges associated with developing therapies that target renal CSCs angiogenesis, immunosuppression, signaling pathways, surface biomarkers, microRNAs and nanomedicine. In conclusion, CSCs are an important role in renal carcinogenesis and represent a valid target for treatment of RCC patients.

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