scholarly journals COPB2: a transport protein with multifaceted roles in cancer development and progression

2021 ◽  
Author(s):  
Y. Feng ◽  
X. Lei ◽  
L. Zhang ◽  
H. Wan ◽  
H. Pan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Complex ◽  
Current Knowledge ◽  
Cancer Development ◽  
Tumor Cell Proliferation ◽  
Invasion And Metastasis ◽  
Hallmarks Of Cancer ◽  
Cancer Types ◽  
Beta 2 ◽  
Cellular Organelles

AbstractThe Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an important role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer.

scholarly journals Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression

2019 ◽  
Vol 20 (18) ◽  
pp. 4407 ◽  
Author(s):  
Tayaba Ismail ◽  
Youni Kim ◽  
Hongchan Lee ◽  
Dong-Seok Lee ◽  
Hyun-Shik Lee
Keyword(s):  
Redox Balance ◽  
Cancer Development ◽  
Cancer Therapies ◽  
Lung Cancers ◽  
Micro Rnas ◽  
Cancer Types ◽  
High Level ◽  
Cancerous Cells ◽  
Ros Scavengers ◽  
Cellular Organelles

Mitochondria are multifunctional cellular organelles that are major producers of reactive oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented with different ROS scavengers, including mitochondrial peroxiredoxins (Prdxs). Mitochondrial Prdxs have physiological and pathological significance and are associated with the initiation and progression of various cancer types. In this review, we have focused on signaling involving ROS and mitochondrial Prdxs that is associated with cancer development and progression. An upregulated expression of Prdx3 and Prdx5 has been reported in different cancer types, such as breast, ovarian, endometrial, and lung cancers, as well as in Hodgkin’s lymphoma and hepatocellular carcinoma. The expression of Prdx3 and Prdx5 in different types of malignancies involves their association with different factors, such as transcription factors, micro RNAs, tumor suppressors, response elements, and oncogenic genes. The microenvironment of mitochondrial Prdxs plays an important role in cancer development, as cancerous cells are equipped with a high level of antioxidants to overcome excessive ROS production. However, an increased production of Prdx3 and Prdx5 is associated with the development of chemoresistance in certain types of cancers and it leads to further complications in cancer treatment. Understanding the interplay between mitochondrial Prdxs and ROS in carcinogenesis can be useful in the development of anticancer drugs with better proficiency and decreased resistance. However, more targeted studies are required for exploring the tumor microenvironment in association with mitochondrial Prdxs to improve the existing cancer therapies and drug development.

scholarly journals Expression of Cancer-Associated Molecules in Malignant Mesothelioma

2007 ◽  
Vol 2 ◽  
pp. 117727190700200 ◽  
Author(s):  
Ben Davidson
Keyword(s):  
Malignant Mesothelioma ◽  
Prognostic Markers ◽  
Current Knowledge ◽  
The Body ◽  
Etiologic Factor ◽  
Common Disease ◽  
Invasion And Metastasis ◽  
Hallmarks Of Cancer ◽  
Anatomic Site ◽  
Cytogenetic Changes

Malignant mesothelioma (MM) is a malignant tumor derived from mesothelial cells, native cells of the body cavities. Exposure to asbestos is the most strongly established etiologic factor, predominantly for the most common disease form, pleural mesothelioma. The pathogenesis of MM involves the accumulation of extensive cytogenetic changes, as well as cancer-related phenotypic alterations that facilitate tumor cell survival, invasion and metastasis. This review presents current knowledge regarding the biological characteristics of this disease that are linked to the so-called hallmarks of cancer. In addition, data suggesting that the anatomic site (solid tumor vs. effusion) affects the expression of metastasis-associated and regulatory molecules in MM are presented. Finally, recent work in which high-throughput methodology has been applied to MM research is reviewed. The data obtained in the reviewed research may aid in defining new prognostic markers and therapeutic targets for this aggressive disease in the future.

scholarly journals Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7611
Author(s):  
Eslam B. Elkaeed ◽  
Hayam A. Abd El Salam ◽  
Ahmed Sabt ◽  
Ghada H. Al-Ansary ◽  
Wagdy M. Eldehna
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Multidrug Resistance ◽  
Small Molecules ◽  
Breast Cancer Treatment ◽  
Cancer Cell Proliferation ◽  
Invasion And Metastasis ◽  
Chemical Structures ◽  
Long Time ◽  
Cancer Types

Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases responsible for a large number of cancer-associated deaths among women worldwide, and diagnosed cases are increasing year by year worldwide. For a very long time, hormonal therapy, surgery, chemotherapy, and radiotherapy were used for breast cancer treatment. However, these treatment approaches are becoming progressively futile because of multidrug resistance and serious side effects. Consequently, there is a pressing demand to develop more efficient and safer agents that can fight breast cancer belligerence and inhibit cancer cell proliferation, invasion and metastasis. Currently, there is an avalanche of newly designed and synthesized molecular entities targeting multiple types of breast cancer. This review highlights several important synthesized compounds with promising anti-BC activity that are categorized according to their chemical structures.

FAT10: Function and Relationship with Cancer

2020 ◽  
Vol 13 (3) ◽  
pp. 182-191 ◽  
Author(s):  
Senfeng Xiang ◽  
Xuejing Shao ◽  
Ji Cao ◽  
Bo Yang ◽  
Qiaojun He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hepatocellular Carcinoma ◽  
Current Knowledge ◽  
Therapeutic Strategies ◽  
Functional Change ◽  
Cancer Development ◽  
Cancer Cell Proliferation ◽  
Biological Functions ◽  
Carcinoma Breast ◽  
Cancer Types

Posttranslational protein modifications are known to be extensively involved in cancer, and a growing number of studies have revealed that the ubiquitin-like modifier FAT10 is directly involved in cancer development. FAT10 was found to be highly upregulated in various cancer types, such as glioma, hepatocellular carcinoma, breast cancer and gastrointestinal cancer. Protein FAT10ylation and interactions with FAT10 lead to the functional change of proteins, including proteasomal degradation, subcellular delocalization and stabilization, eventually having significant effects on cancer cell proliferation, invasion, metastasis and even tumorigenesis. In this review, we summarized the current knowledge on FAT10 and discussed its biological functions in cancer, as well as potential therapeutic strategies based on the FAT10 pathway.

Identification of BAP1-associated MicroRNAs and Implications in Cancer Development

2019 ◽  
pp. 1-4
Author(s):  
Tikam Chand ◽  
Tikam Chand
Keyword(s):  
Gene Regulation ◽  
In Silico ◽  
Mirna Target ◽  
Target Prediction ◽  
Differential Regulation ◽  
Cancer Development ◽  
Mirna Target Prediction ◽  
Cancer Types ◽  
In Silico Tools

Having role in gene regulation and silencing, miRNAs have been implicated in development and progression of a number of diseases, including cancer. Herein, I present potential miRNAs associated with BAP1 gene identified using in-silico tools such as TargetScan and Exiqon miRNA Target Prediction. I identified fifteen highly conserved miRNA (hsa-miR-423-5p, hsa-miR-3184-5p, hsa-miR-4319, hsa-miR125b-5p, hsa-miR-125a-5p, hsa-miR-6893-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-505-3p.1, hsa-miR-429, hsa-miR-370-3p, hsa-miR-125a-5p, hsa-miR-141-3p, hsa-miR-200a-3p, and hsa-miR-429) associated with BAP1 gene. We also predicted the differential regulation of these twelve miRNAs in different cancer types.

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