scholarly journals Inhibitory effects of epigallocatechin gallate and its glucoside on the human intestinal maltase inhibition

2012 ◽  
Vol 17 (5) ◽  
pp. 966-971 ◽  
Author(s):  
Thi Thanh Hanh Nguyen ◽  
Sun-Hwa Jung ◽  
Sun Lee ◽  
Hwa-Ja Ryu ◽  
Hee-Kyoung Kang ◽  
...  
Keyword(s):  
Epigallocatechin Gallate ◽  
Inhibitory Effects ◽  
Human Intestinal Maltase

Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75

2007 ◽  
Vol 109 (3) ◽  
pp. 471-479 ◽  
Author(s):  
Teresa Puig ◽  
Alejandro Vázquez-Martín ◽  
Joana Relat ◽  
Jordi Pétriz ◽  
Javier A. Menéndez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Fatty Acid Metabolism ◽  
Breast Cancer Cells ◽  
Acid Metabolism ◽  
Epigallocatechin Gallate ◽  
Inhibitory Effects

scholarly journals Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang) on P-Glycoprotein

2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
Yuka Watanabe ◽  
Nobutomo Ikarashi ◽  
Toshiyuki Satoh ◽  
Kiyomi Ito ◽  
Wataru Ochiai ◽  
...  
Keyword(s):  
Epigallocatechin Gallate ◽  
Licorice Root ◽  
Drug Transporter ◽  
Inhibitory Effects ◽  
Epicatechin Gallate ◽  
Glycoprotein P ◽  
Atpase Assay ◽  
P Glycoprotein ◽  
Herbal Ingredient

We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp), a drug transporter,in vitro. The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang), which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root) and their components by an ATPase assay using human P-gp membrane. Both rhubarb and licorice root significantly inhibited ATPase activity, and the effects of rhubarb were more potent than those of licorice root. The content of rhubarb in Daiokanzoto is double that in licorice root, and the inhibition patterns of Daiokanzoto and rhubarb involve both competitive and noncompetitive inhibition, suggesting that the inhibitory effects of Daiokanzoto are mainly due to rhubarb. Concerning the components of rhubarb, concentration-dependent inhibitory effects were observed for (−)-catechin gallate, (−)-epicatechin gallate, and (−)-epigallocatechin gallate. In conclusion, rhubarb may cause changes in the drug dispositions of P-gp substrates through the inhibition of P-gp. It appears that attention should be given to the interactions between these drugs and Kampo medicines containing rhubarb as an herbal ingredient.

scholarly journals Inhibitory Effects of (-)-Epigallocatechin Gallate on Spontaneous Hepatoma in C3H/HeNCrj Mice and Human Hepatoma-derived PLC/PRF/5 Cells

1994 ◽  
Vol 85 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Hiroshi Nishida ◽  
Masahide Omori ◽  
Yasushi Fukutomi ◽  
Mitsuo Ninomiya ◽  
Shinji Nishiwaki ◽  
...  
Keyword(s):  
Epigallocatechin Gallate ◽  
Human Hepatoma ◽  
Inhibitory Effects

Investigations of the Effects of Epigallocatechin-3-Gallate and Co2+ on Cal-27 Cells In Vitro

2011 ◽  
Vol 140 ◽  
pp. 167-171
Author(s):  
Jian Sheng Su ◽  
Wen Fei Han ◽  
Hai Bo Wang
Keyword(s):  
Trace Elements ◽  
Adverse Effects ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Inhibitory Effects ◽  
Essential Trace Elements ◽  
Dependent Model ◽  
Dose Dependent ◽  
Mtt Assays

Epigallocatechin gallate (EGCG), a major polyphenol of green tea, has been shown to inhibit the growth of various cancer cell lines. Co2+ is one of essential trace elements of human nutrition, both lack and excess have adverse effects on health.In this research, MTT assays were applied to investigate the effects of Co2+, EGCG and their coactions on Cal-27 cells, The results show that Co2+ and EGCG inhibited the growth of Cal-27 cells in a time-and dose-dependent model, and inhibition effects were extremely dependent on their concentrations, added orders and [Co2+]/[EGCG] ratio. Inhibitory effects of Co2+ could be decreased in the presence of EGCG. LC/MS analysis showed that a new component arised when EGCG and Co2+ were mixed together. It was inferred that the new components were [EGCG-2Co] and [EGCG-Co], and the process might be responsible for the observed effect of the bioactivities of Co2+ against Cal-27 cells.

Inhibitory Effects of (−)-Epigallocatechin Gallate on the Mutation, DNA Strand Cleavage, and DNA Adduct Formation by Heterocyclic Amines

2003 ◽  
Vol 51 (17) ◽  
pp. 5150-5153 ◽  
Author(s):  
Sakae Arimoto-Kobayashi ◽  
Naomi Inada ◽  
Yasuko Sato ◽  
Chitose Sugiyama ◽  
Keinosuke Okamoto ◽  
...  
Keyword(s):  
Epigallocatechin Gallate ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Heterocyclic Amines ◽  
Inhibitory Effects ◽  
Dna Strand
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