Effect of Thyroid Disorders on the Estrous Cycle and its Regulating Hormones of Albino Rats, and the Potential Role of Nigilla Sativa Oil (Nigellar) in Amelioration

2003 ◽  
Vol 33 (3) ◽  
pp. 617-648
Author(s):  
El-Bolkiny E ◽  
Tabl A ◽  
Ghanana Y ◽  
Mansour A
Keyword(s):  
Estrous Cycle ◽  
Potential Role ◽  
Albino Rats ◽  
Thyroid Disorders

scholarly journals Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells

Cephalalgia ◽  
2012 ◽  
Vol 32 (12) ◽  
pp. 924-931 ◽  
Author(s):  
Tanner Boes ◽  
Dan Levy
Keyword(s):  
Mast Cells ◽  
Estrous Cycle ◽  
Potential Role ◽  
Ovarian Hormones ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Migraine Headaches ◽  
Male And Female Rats ◽  
Quantitative Analyses

Background: The frequency of migraine headaches is higher in women than in men and in susceptible women attacks are related to changes in ovarian hormone levels. Intracranial mast cells (MCs) are likely to have a role in migraine headache genesis, and changes in the dural MC population might influence headache susceptibility. The present study thus tested the hypothesis that sex and ovarian hormones influence the density and phenotypic makeup of dural MCs. Methods: Histochemistry combined with quantitative analyses was used to investigate sex differences, estrous cycle and ovarian hormones on dural MC density, phenotype and degranulation level in male and female rats. Results: Our data show that in female rats, dural MC density fluctuates during the estrous cycle and is overall higher than in males. In ovariectomized rats, estradiol, but not progesterone, promoted an increase in dural MC density. This effect was abolished by a splenectomy, suggesting estrogen-related recruitment of MCs from the spleen. Finally, our data suggest that the phenotypic make up of dural MCs, which represents the level of cellular maturity, is also governed by changes in estrogen levels. Conclusions: Given the potential role of dural MCs in triggering headache, our data suggest that estrogen-related modulation of dural MC density and phenotypic makeup could have a role in mediating the higher frequency and severity of headaches such as migraine, in women.

scholarly journals Exploring the Potential Role of Chemopreventive Agent, Hesperetin Conjugated Pegylated Gold Nanoparticles in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Male Wistar Albino Rats

2015 ◽  
Vol 31 (2) ◽  
pp. 171-184 ◽  
Author(s):  
Krishnan Gokuladhas ◽  
Subramaniyan Jayakumar ◽  
Balan Rajan ◽  
Ramasamy Elamaran ◽  
Chengalvarayan Subramani Pramila ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gold Nanoparticles ◽  
Potential Role ◽  
Albino Rats ◽  
Chemopreventive Agent ◽  
Wistar Albino Rats

scholarly journals Potential Role of Thymoquinone in Imidaclopride Induced Testicular Toxicity in Male Albino Rats

2018 ◽  
Vol 34 (3) ◽  
pp. 64-82
Author(s):  
Samy A. Hussein ◽  
Shaaban S. Khalaf-Allah ◽  
Hanan A. Tag El-Din ◽  
Aziza Amin ◽  
Randa M. Khallaf
Keyword(s):  
Potential Role ◽  
Albino Rats ◽  
Testicular Toxicity

Potential Role of Zamzam Water in Some Chronic Diseases in Rats

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Amal S. Abdel-Azeem ◽  
Adel- Elsayed Mubarak ◽  
YahyaAbd- Elmonem Abd-Elhady ◽  
Asmaa Gaber Mohammed Badawi
Keyword(s):  
Diabetes Mellitus ◽  
Potential Role ◽  
Tap Water ◽  
Hdl Cholesterol ◽  
Protective Role ◽  
Serum Glucose ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Normal Rat

Water from holy zamzam is consumed by many Muslims in the world due to its beneficial role for the health of human beings.Therefore the present study was designed to evaluate the effect of zamzam water in diabetes mellitus, nephrotoxicity and hepatotoxicity in rats as well as to determine the chemical analysis of this water. Fifty six male albino rats weighting (150±5gm) were divided into four main groups and each group was divided into two subgroups a and b, one administered tap water (Tw) and the other subgroup administered zamzam water (zw). The 1st main group was normal rat (-ve control), the 2nd group was diabetic (induced by alloxan 150 mg/kg b.w.), the 3rd was nephrotoxic (induced by gentamicin 100 mg/kg b.w.) and the 4th group was hepatotoxic by carbon tetrachloride (2ml/ kg b.w.). The experiment lasted after four weeks. Zamzam water significantly decreased serum glucose, total lipids, total cholesterol, triglycerides, LDL-cholesterol and elevated HDL- cholesterol. Moreover the liver and kidney markers were also improved in the groups that treated with zamzam water relative to its control taking tap water. Zamzam water has a protective role against hazardous effects of diabetes mellitus, nephrotoxicity and hepatotoxicity in rats.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

The Potential Role of the Cytochrome P-450 2D6 Pharmacogenetic Polymorphism in Drug Abuse

1997 ◽  
Author(s):  
Edward M. Sellers ◽  
S. Victoria Otton ◽  
Rachel F. Tyndale
Keyword(s):  
Drug Abuse ◽  
Potential Role ◽  
Cytochrome P 450
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