Microwave-Assisted Fabrication of Silver Nanoparticles Utilizing Seed Extract of Areca catechu with Antioxidant Potency and Evaluation of Antibacterial Efficacy Against Multidrug Resistant Pathogenic Bacterial Strains

2022 ◽  
Author(s):  
Shib Shankar Dash ◽  
Jhimli Banerjee ◽  
Sovan Samanta ◽  
Biplab Giri ◽  
Sandeep Kumar Dash
Keyword(s):  
Silver Nanoparticles ◽  
Multidrug Resistant ◽  
Seed Extract ◽  
Antibacterial Efficacy ◽  
Bacterial Strains ◽  
Microwave Assisted ◽  
Areca Catechu ◽  
Antioxidant Potency

scholarly journals Synthesis of silver nanoparticles using Lactobacillus bulgaricus and assessment of their antibacterial potential

2022 ◽  
Vol 82 ◽  
Author(s):  
Q. A. Naseer ◽  
X. Xue ◽  
X. Wang ◽  
S. Dang ◽  
S. U. Din ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antimicrobial Agents ◽  
Raw Milk ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Lactobacillus Bulgaricus ◽  
Health Concern ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Visible Absorption

Abstract Many pathogenic strains have acquired multidrug-resistant patterns in recent a year, which poses a major public health concern. The growing need for effective antimicrobial agents as novel therapies against multidrug-resistant pathogens has drawn scientist attention toward nanotechnology. Silver nanoparticles are considered capable of killing multidrug-resistant isolates due to their oligo-dynamic effect on microorganisms. In this research study NPs were synthesized using the gram-positive bacteria Lactobacillus bulgaricus and its activity against selected pathogenic strains. Lactobacillus bulgaricus pure cultures were isolated from raw milk and grown in “De Man, Rogasa, and Sharp” broth for synthesis of nanoparticles. Lactobacillus bulgaricus culture was centrifuged and Cell- free supernatant of it was employed with aqueous silvery ions and evaluated their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Staphylococcus epidermidis and Salmonella typhi using agar well diffusion assay. Antibiotic profiling against selected pathogenic strains were also conducted using disc diffusion method. The synthesis and characterization of silver nanoparticles were monitored primarily by the conversion of the pale-yellow color of the mixture into a dark-brown color and via ultraviolet-visible absorption spectroscopy and Scanning electron microscopy respectively. The result showed that that AgNPs with size (30.65-100 nm) obtained from Lactobacillus bulgaricus were found to exhibit antibacterial activities against selected bacterial strains. Taken together, these findings suggest that Lactobacillus bulgaricus has great potential for the production of AgNPs with antibacterial activities and highly effective in comparison to tested antibiotics.

scholarly journals Synergistic and Additive Effect of Oregano Essential Oil and Biological Silver Nanoparticles against Multidrug-Resistant Bacterial Strains

2016 ◽  
Vol 7 ◽  
Author(s):  
Sara Scandorieiro ◽  
Larissa C. de Camargo ◽  
Cesar A. C. Lancheros ◽  
Sueli F. Yamada-Ogatta ◽  
Celso V. Nakamura ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Essential Oil ◽  
Multidrug Resistant ◽  
Additive Effect ◽  
Bacterial Strains ◽  
Oregano Essential Oil

scholarly journals Antimicrobial peptide-modified silver nanoparticles for enhancing the antibacterial efficacy

RSC Advances ◽  
2020 ◽  
Vol 10 (64) ◽  
pp. 38746-38754
Author(s):  
Wenxi Li ◽  
Yongchun Li ◽  
Pengchao Sun ◽  
Nan Zhang ◽  
Yidan Zhao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Antimicrobial Peptide ◽  
Multidrug Resistant ◽  
Antibacterial Efficacy ◽  
Multifunctional Peptides

Multifunctional peptides (MFP)-coated silver nanoparticles (MFP@AgNPs) enhanced the antibacterial activity of AgNPs against multidrug-resistant A. baumannii (MDB-AB) strains.

scholarly journals Extracellular Synthesis and Characterization of Silver Nanoparticles—Antibacterial Activity against Multidrug-Resistant Bacterial Strains

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 360 ◽  
Author(s):  
Gajanan Ghodake ◽  
Min Kim ◽  
Jung-Suk Sung ◽  
Surendra Shinde ◽  
Jiwook Yang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Morphological Changes ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Electron Microscopic ◽  
Visible Absorption ◽  
Membrane Function ◽  
Extracellular Synthesis

Herein, we report the use of a cell-free extract for the extracellular synthesis of silver nanoparticles (AgNPs) and their potential to address the growing threat of multidrug-resistant (MDR) pathogenic bacteria. The reproducibility of AgNP synthesis was good and AgNP formation kinetics were monitored as a function of various reaction factors via ultraviolet-visible absorption spectroscopy. This green method was dependent on the alkaline pH of the reaction mixture. With the addition of dilute sodium hydroxide, well-dispersed AgNPs could be produced in large quantities via the classical nucleation and growth route. The new biosynthetic route enabled the production of AgNPs within a narrow size range of 4 to 17 nm. The AgNPs were characterized using various techniques and their antibacterial activity against MDR pathogenic bacteria was evaluated. Field-emission scanning electron microscopic imaging revealed prominent morphological changes in Staphylococcus aureus cells due to mechanical damage, which led to cell death. Escherichia coli cells showed signs of contraction and intracellular fluid discharge as a consequence of disrupted cell membrane function. This new biologically-assisted extracellular strategy is potentially useful for the decontamination of surfaces and is expected to contribute to the development of new products containing AgNPs.

scholarly journals Biosynthesized Silver Nanoparticles Using an Aqueous Root Extract of Iris germanica as a Reducing Agent and Its Antibacterial Efficacy

2020 ◽  
pp. 1-10
Author(s):  
Vaghela Hiral ◽  
Shah Rahul ◽  
Vajapara Shailesh ◽  
Pathan Amanullakhan
Keyword(s):  
Silver Nanoparticles ◽  
Research Area ◽  
Reduction Reaction ◽  
Reducing Agent ◽  
Biomedical Science ◽  
Root Extract ◽  
Antibacterial Efficacy ◽  
Bacterial Strains ◽  
Iris Germanica ◽  
Aqueous Root Extract

Biosynthesized silver nanoparticles (AgNPs) are environment friendly, cost-effective, bio-compatible and expanding research area due to their potential applications in medical domain. The present study focuses on biologically synthesized of AgNPs using aqueous root extract of  Iris germanica as reducing agent as well as capping agent and examined their potential antibacterial efficacy. In reduction reaction it was observed that silver (Ag+1) ions associate in root extract and reduced in solution (Ag0) leads to formation of stable formation of spherical AgNPs. Biosynthesized AgNPs showed an effective and rapid antibacterial activity against both bacterial strain (gram+ve and gram-ve). Results exhibited that AgNPs were extremely toxic towards Bacillus subtilis and Escherichia coli pathogenic bacterial strains and can be utilized for the applications in biomedical science.

scholarly journals Substituted-Amidine Functionalized Monocyclic β-Lactams: Synthesis and In Vitro Antibacterial Profile

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Lili He ◽  
Lijuan Zhai ◽  
Jian Sun ◽  
Jingwen Ji ◽  
Jinbo Ji ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Gram Negative Bacteria ◽  
Antibacterial Efficacy ◽  
Clinical Use ◽  
Bacterial Strains ◽  
Antibiotic Drug ◽  
Clinical Interest ◽  
Derivatives Of

Background. Owing to the intrinsic stability against common β-lactamases and metallo-lactamases, monobactams gathered special attention in antibiotic drug development. However, so far, aztreonam is the only monobactam approved by FDA for clinical use. We designed new derivatives of aztreonam to enhance its antibacterial efficacy. Methods. We synthesized a series of monocyclic β-lactams by modifying mainly at the C3 position of azetidinone ring. NH2 group at C3 of azetidinone was attached to thiazole and thiadiazole which in turn was linked to nitrogenous heterocyclic rings via amidine moieties. We then investigated the in vitro antibacterial activities of synthesized compounds against ten bacterial strains of clinical interest in comparison to aztreonam and ceftazidime. Results. All compounds showed improved antibacterial activities against tested strains compared to reference drugs. Compounds 14d and 14e were most potent and showed the highest potency against all bacterial strains, with MIC values ranging from 0.25 µg/mL to 8 µg/mL, as compared to aztreonam (MIC 16 µg/mL to >64 µg/mL) and ceftazidime (MIC >64 µg/mL). These compounds (14d and 14e) may be valuable lead targets against multidrug-resistant Gram-negative bacteria.

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