The Effect of Different Doses and Different Routes of Acetylsalicylic Acid Administration on Platelet Aggregation in Healthy Volunteers and Ischemic Stroke Patients

2014 ◽  
Vol 6 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Miroslava Chýlová ◽  
Zuzana Moťovská ◽  
Pavel Osmančík ◽  
Bohumír Procházka ◽  
Pavel Kalvach
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Acetylsalicylic Acid ◽  
Healthy Volunteers ◽  
Stroke Patients ◽  
Acid Administration ◽  
Different Doses

ASSOCIATION OF PLATELET-DERIVED MICROVESICLES WITH HIGH ON-TREATMENT PLATELET REACTIVITY IN CONVALESCENT ISCHEMIC STROKE PATIENTS TREATED WITH ACETYLSALICYLIC ACID

2019 ◽  
Vol 72 (8) ◽  
pp. 1426-1436
Author(s):  
Justyna Rosińska ◽  
Joanna Maciejewska ◽  
Robert Narożny ◽  
Wojciech Kozubski ◽  
Maria Łukasik
Keyword(s):  
Platelet Aggregation ◽  
Treatment Failure ◽  
Acetylsalicylic Acid ◽  
Platelet Reactivity ◽  
Study Groups ◽  
Surface Expression ◽  
Cerebrovascular Diseases ◽  
Stroke Patients ◽  
Vascular Events ◽  
The Impact

Introduction: Elevated concentrations of platelet-derived microvesicles are found in cerebrovascular diseases. The impact of acetylsalicylic acid on these microvesicles remains inconsistent, despite its well-established effect on platelet aggregation. High residual platelet aggregation is defined as high on-treatment platelet reactivity, while “treatment failure” is the occurrence of vascular events despite antiplatelet treatment. The aim of this study was to determine whether the antiaggregatory effect of acetylsalicylic acid correlates with platelet-derived microvesicles in convalescent ischaemic stroke patients and cardiovascular risk factor controls as well as to evaluate the association between high on-treatment platelet reactivity and recurrent vascular events with the studied platelet-derived microvesicle parameters. Materials and methods: The study groups consisted of 76 convalescent stroke patients and 74 controls. Total platelet-derived microvesicles, annexino-positive microvesicles number, and platelet-derived microvesicles with surface expression of proinflammatory (CD40L, CD62P, CD31) and procoagulant (PS, GPIIb/IIIa) markers were characterized and quantified using flow cytometry. Cyclooxygenase-1-specific platelet responsiveness, with whole blood impedance platelet aggregation under arachidonic acid stimulation and the serum concentration of thromboxane B2, were evaluated. Results: Neither acetylsalicylic acid intake nor modification of its daily dose caused statistically significant differences in the studied microvesicle parameters. Additionally, no statistically significant differences in the studied microvesicle parameters were revealed between high on-treatment platelet reactivity and non-high on-treatment platelet reactivity subjects in either study subgroup. However, elevated concentrations of PAC-1+/CD61+, CD62P+/CD61+ and CD31+/CD61+ microvesicles were found in stroke patients with treatment failure, defined in this study as a recurrent vascular events in a one-year follow-up period. Conclusions: This study revealed no relationship between circulating microvesicle number and platelet aggregation. The procoagulant and proinflammatory phenotype of circulating platelet-derived microvesicles might contribute to acetylsalicylic acid treatment failure.

Acetylsalicylic Acid Daily vs Acetylsalicylic Acid Every 3 Days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa, and Prostaglandin E2Synthesis

2016 ◽  
Vol 56 (7) ◽  
pp. 862-868 ◽  
Author(s):  
Plinio Minghin Freitas Ferreira ◽  
Thiago Gagliano-Jucá ◽  
Tiago Zaminelli ◽  
Marinalva Ferreira Sampaio ◽  
Rory Willian Blackler ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Gastric Mucosa ◽  
Acetylsalicylic Acid ◽  
Healthy Volunteers

Platelet aggregation on whole blood after administration of ultra low dosage acetylsalicylic acid in healthy volunteers

1987 ◽  
Vol 47 (3) ◽  
pp. 373-377 ◽  
Author(s):  
C. Doutremepuich ◽  
O. de Seze ◽  
M.C. Anne ◽  
E. Hariveau ◽  
R. Quilichini
Keyword(s):  
Platelet Aggregation ◽  
Acetylsalicylic Acid ◽  
Healthy Volunteers ◽  
Whole Blood ◽  
Low Dosage

scholarly journals Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Alejandro Roman-Gonzalez ◽  
Carlos Andrés Naranjo ◽  
Walter D. Cardona-Maya ◽  
Dionis Vallejo ◽  
Francisco Garcia ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Univariate Analysis ◽  
Aspirin Resistance ◽  
Aspirin Therapy ◽  
Stroke Recurrence ◽  
Healthy Controls ◽  
Test Results ◽  
Stroke Patients ◽  
Ischemic Cerebrovascular Disease

Objective. To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. Materials and Methods. Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. Results. Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis ( p = 0.004 ). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. Conclusion. Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.

scholarly journals Relationship between Blood Lipids, Lipoproteins and Ischemic Stroke

2014 ◽  
Vol 30 (2) ◽  
pp. 96-103
Author(s):  
Md Rezaul Karim Khan ◽  
AKM Anwarullah ◽  
Md Shafiqus Saleheen ◽  
SK Mahbub Alam ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Healthy Volunteers ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Hdl Cholesterol ◽  
Stroke Patients ◽  
Lipids And Lipoproteins ◽  
Control Study ◽  
Apparently Healthy

Objective: To find out the relationship of different lipids, lipoproteins and ischemic stroke patients in Bangladesh. Methodology: This case control study was conducted among the patients having ischemic stroke who were admitted in Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from July, 1997 to June, 1999 and age, sex matched apparently healthy volunteers. Sixty ischemic stroke patients confirmed by CT scan of brain and sixty age and sex matched apparently healthy volunteers were enrolled as controls. 12 hours fasting lipid profile (Total cholesterol, LDL-cholesterol, HDLcholesterol and Triglyceride) was done for both ischemic stroke patients and healthy volunteers for comparison. The students (unpaired) t test was used to compare group means for lipids and lipoproteins. Chi square test, odds ratio with confidence interval were done to evaluate differences between the groups for other variables. P<0.05 was considered as minimum level of significance. Result: The mean age (±SD) of the patients and controls were 58.45±10.12 and 59.40±10.41 years respectively and 44 (73.3%) were male and 16 (26.7%) were female and male- female ratio was 2.75:1 in both cases and controls. Total cholesterol (Means) was 201.62±5.52 mg/dl and 169.13±3.49 mg/dl in cases and controls respectively (P<0.001). HDL cholesterol (Means) was 38.36±0.81 mg/dl and 44.03±0.84 mg/dl in cases and controls respectively (P<0.001). LDL cholesterol (Mean±SE) in ischemic stroke patients and controls were 125.45±4.63 mg/dl and 96.40±3.23 mg/dl respectively (P<0.001). Triglyceride (Mean±SE) in cases and controls were 188.50±9.35 mg/dl and 142.85±4.72 mg/dl respectively (P<0.001). Conclusion: This case-control study showed significant differences of serum lipids and lipoproteins (Total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in ischemic stroke patients than the controls in our community. Bangladesh Journal of Neuroscience 2014; Vol. 30 (2): 96-103

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