Hepatoprotective activity of methanol extract of Litsea glutinosa against hepatotoxin induced toxicity

2016 ◽  
Vol 16 (2) ◽  
pp. 139-146
Author(s):  
Nilanjan Ghosh ◽  
Rituparna Chaki ◽  
Mahadeb Pal ◽  
Subhash C. Mandal
Keyword(s):  
Methanol Extract ◽  
Hepatoprotective Activity ◽  
Litsea Glutinosa

scholarly journals Evaluation of Hepatoprotective and in vivo Antioxidant Potentials of Methanol Extract of Tephrosia pumila against Thioacetamide Induced Liver Toxicity in Wistar Rats

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ramesh C ◽  
Pinkey Rawal ◽  
Soma Pramanik ◽  
Shabana S
Keyword(s):  
Biochemical Parameters ◽  
Methanol Extract ◽  
Liver Toxicity ◽  
Antioxidant Properties ◽  
Total Duration ◽  
Hepatoprotective Activity ◽  
Oral Toxicity ◽  
Standard Drug ◽  
Protein Ions

The objective of the current investigation was performed to assess the hepatoprotective potentials and in vivo antioxidant properties of methanol extract of Tephrosia pumila against thioacetamide induced liver damage in rats. The acute oral toxicity study of methanol extract was determined as per OECD guidelines and the extract was proved to be safe up to the dose of 2000mg/kg. The total duration of the study was 21 days and animals were divided into six groups. Hepatotoxicity was induced in the animals of all groups except normal control by single dose administration of Thioacetamide(100mg/kg) at first day of the study followed by animals were treated daily with standard drug sylimarin and methanol extract of Tephrosia pumila (100mg/kg, 200mg/kg and 400mg/kg) to respective groups for 21 days. Variations in biochemical parameters like alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, total protein, ions and others parameters like clotting time and weight of the liver were considered to determine beneficial effect of the extract. At the end of the study liver samples were collected and subjected to histopathological evaluation. There were significant variations in the above mentioned biochemical parameters in toxic control animals treated with Thioacetamide alone while in the animals treated with methanol extract and standard drug silymarin, all the parameters were normal possibly due to their beneficial property in protecting the liver against thioacetamide induced hepatotoxicity. The results obtained in the above study suggesting that, the methanol extract of Tephrosia pumila possess significant hepatoprotective activity.

Pharmacological and Pathological Studies on Taiwan Folk Medicine (IX): The Hepatoprotective Effect of the Methanolic Extract from Echinops Grijisii

1993 ◽  
Vol 21 (01) ◽  
pp. 33-44 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-Hung Lin
Keyword(s):  
Liver Biopsy ◽  
Ethyl Acetate ◽  
Liver Damage ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Wistar Albino Rats

In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC14-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.

Antioxidant and hepatoprotective activity of the methanol extract of Careya arborea bark in Ehrlich ascites carcinoma-bearing mice

2008 ◽  
Vol 62 (3) ◽  
pp. 336-339 ◽  
Author(s):  
Natesan Senthilkumar ◽  
Shrishailappa Badami ◽  
Santoshkumar H. Dongre ◽  
Suresh Bhojraj
Keyword(s):  
Methanol Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Hepatoprotective Activity ◽  
Ehrlich Ascites

scholarly journals Preliminary phytochemical screening and hepatoprotective activity of methanol extract of Artocarpus hirsutus leaves.

2016 ◽  
Vol 8 (3) ◽  
pp. 379
Author(s):  
Jitendra Patel ◽  
Venkateshwar Reddy ◽  
GS Kumar
Keyword(s):  
Total Bilirubin ◽  
Methanol Extract ◽  
Hepatoprotective Activity ◽  
Direct Bilirubin ◽  
Control Group ◽  
Phytochemical Screening ◽  
Methanolic Extracts ◽  
Group I ◽  
Hepatic Protection

<p>The objective of the present work was investigating the preliminary phytochemical screening and hepatoprotective activity of methanol extract of the leaves of <em>Artocarpus hirsutus</em>.<strong></strong></p><p>Group I served as vehicle control, Group II served CCL<sub>4 </sub>(2ml/kg, s.c.), Group III served as standard Silymarin (50 mg/kg, p.o.)  Group IV and V served as methanolic extracts of <em>Artocarpus hirsutus</em><strong> </strong>(MEAH) at the dose level (250 and 500 mg/kg, p.o.). The degree of protection was determined by measuring level biochemical marker like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin, total bilirubin and Cholesterol. The histopathology study also showed the hepatic protection of extracts. The preliminary phytochemical screening was performed to find out the phytoconstituents responsible for the activity.<strong></strong></p><p>The marker biochemical level such as ALT, AST, ALP, Direct bilirubin, Total bilirubin and Cholesterol were significantly raised in CCL<sub>4 </sub>treated rats when compared with the normal group (p&lt;0.05), but the MEAH (500 mg/kg, bw) treated rats exhibited maximum depletion. The histopathology study also showed the hepatic protection of extracts. Preliminary phytochemical screening showed the presence of glycosides, flavonoids, Tannins, triterpenoids, carbohydrates and steroids.</p><p>The results of <em>in vivo</em> hepatoprotective activity showed that the methanol extract of <em>Artocarpus hirsutus</em><strong> </strong>exhibit significant hepatoprotective activity. This might be due to flavonoids and tannins; which was confirmed their presence in phytochemical tests.  </p>

Antioxidant and Hepatoprotective Effects ofAnoectochilus formosanusandGynostemma pentaphyllum

2000 ◽  
Vol 28 (01) ◽  
pp. 87-96 ◽  
Author(s):  
Chun-Ching Lin ◽  
Pei-Chen Huang ◽  
Jer-Min Lin
Keyword(s):  
Liver Injury ◽  
Hepatic Injury ◽  
Methanol Extract ◽  
Antiinflammatory Activity ◽  
Water Extract ◽  
Hepatoprotective Activity ◽  
Central Vein ◽  
Crude Drugs ◽  
Anoectochilus Formosanus ◽  
Antioxidant Effects

Anoectochilus formosanus Hay. and Gynostemma pentaphyllum Makino are popular folk medicines that have been used for treating hepatitis, hypertension and cancer in Taiwan. Our previous studies showed that these crude drugs exert antiinflammatory activity and hepatoprotective activity against CCI4-induced liver damage. In this study, the antioxidant effect of these crude drugs and their hepatoprotective activity on acetaminophen-induced liver injury in rat was evaluated. Our results suggest that A. formosanus and G. pentaphyllum do have antioxidant effects. On acetaminophen-intoxicated model, the increased levels of aspartate aminotransferase (AST) and alanine aminotrans-ferase (ALT) by acetaminophen administration were reduced by treatment with these two herbs. In histological observation, gross necrosis in the centribular area, sinusoidal congestion, infiltration of the lymphocytes and Kupffer cells around the hepatic central vein, and loss of cell boundaries and ballooning degeneration were reduced with herbal treatment. However, the effect of A. formosanus and G. pentaphyllum is biphasic. Methanol extract (100 and 300 mg/kg) and water extract (300 and 500 mg/kg) of A formosanus and water extract (100, 300 and 500 mg/kg) of G. pentaphyllum enhanced the recovery of liver injury while treatment with 500 mg/kg of A. formosanus methanol extract resulted in serious hepatic injury.

Hepatoprotective activity of aqueous-methanol extract ofArtemisia vulgaris

2005 ◽  
Vol 19 (2) ◽  
pp. 170-172 ◽  
Author(s):  
Anwarul Hassan Gilani ◽  
Sheikh Yaeesh ◽  
Qamar Jamal ◽  
M. Nabeel Ghayur
Keyword(s):  
Methanol Extract ◽  
Hepatoprotective Activity ◽  
Aqueous Methanol

scholarly journals HEPATOPROTECTIVE EFFECTS OF PHENOLIC GLYCOSIDES FROM THE METHANOL EXTRACT OF PHYSALIS ANGULATA

2017 ◽  
Vol 55 (2) ◽  
pp. 161 ◽  
Author(s):  
Hoang Le Tuan Anh ◽  
Duong Thi Dung ◽  
Dong Thanh Tuan ◽  
Trieu Quy Hung ◽  
Pham Thi Hai Yen ◽  
...  
Keyword(s):  
Methanol Extract ◽  
2D Nmr ◽  
Hepatoprotective Activity ◽  
Phenolic Glycosides ◽  
Chromatographic Separations ◽  
Spectroscopic Analyses ◽  
Whole Plant ◽  
Physalis Angulata ◽  
Hepatoprotective Effects ◽  
Reported Data

By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-O-triglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and in comparison with the reported data. Compounds 3 exhibited significantly hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata.

scholarly journals Evaluation of Hepatoprotective Activity ofAdansonia digitataExtract on Acetaminophen-Induced Hepatotoxicity in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Abeer Hanafy ◽  
Hibah M. Aldawsari ◽  
Jihan M. Badr ◽  
Amany K. Ibrahim ◽  
Seham El-Sayed Abdel-Hady
Keyword(s):  
Oxidative Stress ◽  
Methanol Extract ◽  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Fruit Pulp ◽  
Adansonia Digitata ◽  
Oxidative Stress Parameter ◽  
Inflammatory Infiltration ◽  
Liver Functions ◽  
Antioxidant Markers

The methanol extract of the fruit pulp ofAdansonia digitataL. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. In addition, hepatospecific serum markers will be disturbed. Treatment of the rats with the methanol extract of the fruit pulp ofAdansonia digitataL. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST. Oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis. Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp ofAdansonia digitataL. to ensure safety of the fruit extract.

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