scholarly journals Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients

Author(s):  
Nobunao Ikewaki ◽  
Masaru Iwasaki ◽  
Samuel J. K. Abraham

Abstract With the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeast Aureobasidium pullulans AFO-202 which has been proven to bring under control blood sugar levels in human subjects and also has potential in enhancing & regulating the immune parameters in relevance to COVID-19. We further recommend that this BRMG be tried in clinical studies of COVID-19 to provide a prophylactic effect for validation.

1994 ◽  
Vol 5 (suppl a) ◽  
pp. 5A-8A
Author(s):  
Jay P Siegel

OBJECTIVE: To present perspectives on selected issues that frequently arise during the clinical development of biological response modifier (BRM) therapies.DATA SOURCES: The perspectives and opinions presented herein were developed over several years of reviewing and consulting on the clinical development of BRM therapies at the United States Food and Drug Administration.CONCLUSIONS: BRM therapies encompass a broad spectrum of products used to treat a wide variety of diseases. Due to this diversity. most principles of clinical trial design and conduct applicable to the majority of BRMS are those that are applicable to all therapies. Nevertheless, the clinical development of BRM therapies often raises specific issues and problems in the areas of selecting animal models, defining the study population, adverse reactions, dosing and defining end-points. Over 10 years’ experience in testing biotechnology derived BRMS in clinical trials has created a database from which we can draw valuable generalizations for guidance in future studies.


2018 ◽  
Vol 41 (5) ◽  
pp. 505-516 ◽  
Author(s):  
Carsten Pelz ◽  
Sonja Häckel ◽  
Geo Semini ◽  
Sandra Schrötter ◽  
Willem Bintig ◽  
...  

1992 ◽  
Vol 235 ◽  
pp. 247-257 ◽  
Author(s):  
David L. Williams ◽  
Henry A. Pretus ◽  
Rose B. McNamee ◽  
Ernest L. Jones ◽  
Harry E. Ensley ◽  
...  

Oncology ◽  
1994 ◽  
Vol 51 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Kenichi Matsunaga ◽  
Mika Aota ◽  
Yuko Nyunoya ◽  
Mitsunori Hakozaki ◽  
Yoshiaki Ishikawa ◽  
...  

BMC Cancer ◽  
2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Christian Sänger ◽  
Andreas Busche ◽  
Gabriele Bentien ◽  
Ralf Spallek ◽  
Fatima Jonas ◽  
...  

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