One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T1-Weighted Magnetic Resonance Imaging In vivo

2019 ◽  
Vol 35 (3) ◽  
pp. 537-541 ◽  
Author(s):  
Sa Huang ◽  
Qinghe Han ◽  
Lei Wang ◽  
Tingting Gong ◽  
Qinghai Yuan
RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50557-50564 ◽  
Author(s):  
Longyun Wu ◽  
ChunYan Yang ◽  
Zhongwen Lv ◽  
FengWen Cui ◽  
Lijun Zhao ◽  
...  

A facile and efficient one-pot solvothermal strategy is described to synthesize Fe3O4 nanoparticles (NPs) modified with sodium citrate, polyvinylpyrrolidone and l-asparagine for in vivo magnetic resonance (MR) imaging of melanoma cells.


2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>


Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2855-2860 ◽  
Author(s):  
Haibo Wang ◽  
Wei Lu ◽  
Tianmei Zeng ◽  
Zhigao Yi ◽  
Ling Rao ◽  
...  

A new type of multi-functional NaErF4 nanoprobe with enhanced red upconversion emission was developed and used for in vitro cell, in vivo X-ray and T2-weighted magnetic resonance imaging for the first time.


2019 ◽  
Vol 10 (13) ◽  
pp. 3770-3778 ◽  
Author(s):  
Huan Wang ◽  
Dongqin Yu ◽  
Bo Li ◽  
Zhen Liu ◽  
Jinsong Ren ◽  
...  

Novel ROS-activated contrast agents are designed for magnetic resonance imaging of ROS for early diagnosis of sepsis.


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