scholarly journals Evaluation of Blood Pressure and Heart Rate in Patients with Hypertension Who Received Tapentadol Extended Release for Chronic Pain: A Post Hoc, Pooled Data Analysis

2014 ◽  
Vol 34 (8) ◽  
pp. 565-576 ◽  
Author(s):  
David M. Biondi ◽  
Jim Xiang ◽  
Mila Etropolski ◽  
Bruce Moskovitz
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Chronic Pain ◽  
Data Analysis ◽  
Extended Release ◽  
Pooled Data ◽  
Post Hoc

scholarly journals The effects of propranolol on heart rate variability and quantitative, mechanistic, pain profiling: a randomized placebo-controlled crossover study

2018 ◽  
Vol 18 (3) ◽  
pp. 479-489 ◽  
Author(s):  
Kristian Kjær Petersen ◽  
Hjalte Holm Andersen ◽  
Masato Tsukamoto ◽  
Lincoln Tracy ◽  
Julian Koenig ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Chronic Pain ◽  
Pain Sensitivity ◽  
Experimental Pain ◽  
Central Pain ◽  
Healthy Male ◽  
Pain Pathways ◽  
Β Blocker ◽  
Chronic Pain Conditions

AbstractBackground and aimsThe autonomic nervous system (ANS) is capable of modulating pain. Aberrations in heart rate variability (HRV), reflective of ANS activity, are associated with experimental pain sensitivity, chronic pain, and more recently, pain modulatory mechanisms but the underlying mechanisms are still unclear. HRV is lowered during experimental pain as well as in chronic pain conditions and HRV can be increased by propranolol, which is a non-selective β-blocker. Sensitization of central pain pathways have been observed in several chronic pain conditions and human mechanistic pain biomarkers for these central pain pathways include temporal summation of pain (TSP) and conditioned pain modulation (CPM). The current study aimed to investigate the effect of the β-blocker propranolol, and subsequently assessing the response to standardized, quantitative, mechanistic pain biomarkers.MethodsIn this placebo-controlled, double-blinded, randomized crossover study, 25 healthy male volunteers (mean age 25.6 years) were randomized to receive 40 mg propranolol and 40 mg placebo. Heart rate, blood pressure, and HRV were assessed before and during experimental pain tests. Cuff pressure pain stimulation was used for assessment of pain detection (cPDTs) and pain tolerance (cPTTs) thresholds, TSP, and CPM. Offset analgesia (OA) was assessed using heat stimulation.ResultsPropranolol significantly reduced heart rate (p<0.001), blood pressure (p<0.02) and increased HRV (p<0.01) compared with placebo. No significant differences were found comparing cPDT (p>0.70), cPTT (p>0.93), TSP (p>0.70), OA-effect (p>0.87) or CPM (p>0.65) between propranolol and placebo.ConclusionsThe current study demonstrated that propranolol increased HRV, but did not affect pressure pain sensitivity or any pain facilitatory or modulatory outcomes.ImplicationsAnalgesic effects of propranolol have been reported in clinical pain populations and the results from the current study could indicate that increased HRV from propranolol is not associated with peripheral and central pain pathways in healthy male subjects.

scholarly journals Estimating minute ventilation and air pollution inhaled dose using heart rate, breath frequency, age, sex and forced vital capacity: A pooled-data analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0218673 ◽  
Author(s):  
Roby Greenwald ◽  
Matthew J. Hayat ◽  
Evi Dons ◽  
Luisa Giles ◽  
Rodrigo Villar ◽  
...  
Keyword(s):  
Heart Rate ◽  
Air Pollution ◽  
Data Analysis ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Minute Ventilation ◽  
Pooled Data

scholarly journals THE RELATIONSHIP OF BLOOD PRESSURE AND HEART RATE TO VO2MAX IN ADOLESCENT

2021 ◽  
Vol 5 (1) ◽  
pp. 41-49
Author(s):  
TYAS SARI RATNA NINGRUM
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Data Analysis ◽  
Sampling Technique ◽  
Pulse Frequency ◽  
Purposive Sampling ◽  
A Value ◽  
Blood Pressure Data ◽  
Kolmogorov Smirnov ◽  
The Relationship

ABSTRAK Pendahuluan : Selama aktivitas fisik yang kita lakukan maka akan terjadi perubahan tekanan darah denyut nadi sebagai respon untuk mengangkut O2 ke otot yang sedang beraktivitas. Adolescent usia 18-21 tahun jaman sekarang memiliki masalah terkait dengan gerak yang mengakibatkan menurunnya ketahanan latihan. Tujuan : menganalisa hubungan antara perubahan tekanan darah dan nadi terhadap VO2Max dan menganalisa seberapa erat hubungannya. Metode : penelitian ini merupakan penelitian observatif dengan Teknik pengambilan sampel purposive sampling  dengan desain point time approach sejumlah 183 sampel dengan kriteria usia 18-21 tahun. Variabel independent pada penelitian ini adalah ketahanan latihan, dan variabel dependent adalah perubahan tekanan darah dan perubahan frekuensi nadi. Data diolah menggunakan perangkat lunak untuk Analisa data. Hasil : Dari uji normalitas data menggunakan Kolmogorov Smirnov untuk data tekanan darah dengan nilai 0.509, data nadi  dengan nilai 0.069, data VO2Max dengan nilai 0.060. Uji Analisa data menggunakan uji pearson product moment  menghasilkan nilai tekanan darah -0.000 dengan nilai r -0.029 dan nilai -0.029. Kesimpulan : terdapat hubungan perubahan tekanan darah dan nadi terhadap VO2Max. Kata Kunci : Tekanan darah, Nadi, VO2Max   ABSTRACT Introduction: During the physical activity that we do, there will be a change in pulse blood pressure in response to transporting O2 to the muscles that are on the move. Adolescents 18-21 years of age today have problems related to movement that result in decreased resistance training. Purpose: to analyze the relationship between changes in blood pressure and pulse to VO2Max and to analyze how closely it is. Methods: This study is an observative study using purposive sampling technique with a point time approach design with a total of 183 samples with criteria aged 18-21 years. The independent variable in this study is exercise resistance, and the dependent variable is changes in blood pressure and changes in pulse frequency. The data is processed using software for data analysis. Results: From the data normality test using Kolmogorov Smirnov for blood pressure data with a value of 0.509, pulse data with a value of 0.069, VO2Max data with a value of 0.060. Test Data analysis using the Pearson product moment test resulted in a blood pressure value of -0.000 with a value of r -0.029 and a value of -0.029. Conclusion: there is a relationship between changes in blood pressure and pulse to VO2Max. Keyword : Blood Pressure, Heart Rate, VO2Max

scholarly journals Treatment of intraoperative hypotension with cafedrine/theodrenaline versus ephedrine

2020 ◽  
Author(s):  
L. Eberhart ◽  
◽  
G. Geldner ◽  
A. Kowark ◽  
T.-P. Zucker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Treatment Satisfaction ◽  
Open Label ◽  
Post Hoc Analysis ◽  
Intraoperative Hypotension ◽  
Sympathomimetic Drugs ◽  
Restore Blood Pressure ◽  
Secondary Endpoints ◽  
Post Hoc

Abstract Background Sympathomimetic drugs are a therapeutic cornerstone for the management of hypotensive states like intraoperative hypotension (IOH). While cafedrine/theodrenaline (C/T) is widely used in Germany to restore blood pressure in patients with IOH, more research is required to compare its effectiveness with alternatives such as ephedrine (E) that are more commonly available internationally. Methods HYPOTENS (NCT02893241, DRKS00010740) was a prospective, national, multicenter, open-label, two-armed, non-interventional study that compared C/T with E for treatment of IOH. We describe a prospectively defined cohort of patients ≥50 years old with comorbidities undergoing general anesthesia induced with propofol and fentanyl. Primary objectives were to examine treatment precision, rapidity of onset and the ability to restore blood pressure without relevant increases in heart rate. Secondary endpoints were treatment satisfaction and the number of required additional boluses or other accompanying measures. Results A total of 1496 patients were included in the per protocol analysis. Overall, effective stabilization of blood pressure was achieved with both C/T and E. Post-hoc analysis showed that blood pressure increase from baseline was more pronounced with C/T. Fewer additional boluses or other accompanying measures were required in the C/T arm. The incidence of tachycardia was comparable between groups. Post-hoc analysis showed that E produced dose-dependent elevated heart rate values. By contrast, heart rate remained stable in patients treated with C/T. Physicians reported a higher level of treatment satisfaction with C/T, with a higher proportion of anesthetists rating treatment precision and rapidity of onset as good or very good when compared with E. Conclusion Neither drug was superior in restoring blood pressure levels; however, post-hoc analyses suggested that treatment is more goal-orientated and easier to control with C/T. Heart rate was shown to be more stable with C/T and fewer additional interventions were required to restore blood pressure, which could have contributed to the increased treatment satisfaction reported by anesthetists using C/T.

scholarly journals 0556 Sex-Specific Relationship Between Anxiety and Autonomic Nervous System Dysfunction in Obstructive Sleep Apnea

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A213-A213
Author(s):  
A Pal ◽  
M A Akey ◽  
R Chatterjee ◽  
A P Aguila ◽  
F Martinez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sleep Apnea ◽  
Anxiety Symptoms ◽  
Female Age ◽  
Obstructive Sleep ◽  
Post Hoc

Abstract Introduction Cardiovascular co-morbidities in obstructive sleep apnea (OSA) are hard to treat, perhaps due to autonomic nervous system (ANS) dysfunction. In OSA, intermittent hypoxia and poor tissue oxygen perfusion damage endothelial and nervous tissue, potentially underlying the dysfunction. Moreover, OSA is strongly associated with anxiety, which is independently associated with ANS dysfunction. We assessed sex-specific relationships between anxiety and cardiovascular markers of ANS dysfunction in OSA. Methods We studied people diagnosed with OSA and healthy controls. We collected 5 minutes of wakeful resting ECG, continuous non-invasive blood pressure, and respiration data. We calculated heart rate (HR), heart rate variability (HRV; sympathetic-vagal balance related to brainstem ANS output), mean arterial blood pressure (MAP), beat-to-beat MAP variability (BPV; related to peripheral autonomic function) and breathing rate (BR). We analyzed these measures with a multivariate regression model of anxiety symptoms (generalized anxiety disorder; GAD-7 scores), sex, and group (OSA vs. control), age/BMI/AHI covariates, and Bonferroni-corrected post-hoc comparisons (p≤0.05). Results We analyzed 64 subjects (32 OSA: AHI [mean±SEM] 24±4events/hour, 12 female, age 52±21years, BMI 33±2kg/m2; 32 control: 19 female, age 46±2; BMI 26±1). We observed significant main effects of anxiety, BMI, AHI, sex on HRV, but only group on BPV; post-hoc comparisons revealed high BPV only in OSA females. Secondary analyses included classifying by anxiety symptoms (GAD-7≥5), showing only OSA females with anxiety had higher BPV. Males showed higher HRV. AHI and anxiety were positively correlated with HRV in OSA males. AHI was negatively correlated with BR in OSA females. Conclusion We observed higher anxiety associated with higher BPV in OSA, especially in females. Unexpectedly, BR was lower in OSA females; longer breaths may have led to the greater BPV. Higher HRV in males complicated by OSA severity and anxiety could be related to higher sympathetic tone. The slightly older control group may have influenced the findings. Overall, our findings suggest anxiety in OSA is associated with peripheral and centrally-mediated autonomic dysfunction, but in a sex-specific manner. Support National Institutes of Health R56-NR-017435 and RO1-HL-135562.

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