Role of Caspase-8 as a Prognostic Biomarker in Breast Cancer—A Pilot Study in Central India

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
Kailas Shrikrishna Kotalwar ◽  
Abhay Vilas Deshmukh ◽  
Nitin M. Gangane
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Prognostic Biomarker ◽  
Central India ◽  
Caspase 8

scholarly journals Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

2020 ◽  
Vol 21 (16) ◽  
pp. 5834
Author(s):  
Anna Maria Grimaldi ◽  
Silvia Nuzzo ◽  
Gerolama Condorelli ◽  
Marco Salvatore ◽  
Mariarosaria Incoronato
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Prognostic Biomarker ◽  
Survival Rates ◽  
Prognostic Significance ◽  
Unmet Need ◽  
Non Invasive ◽  
Clinicopathological Significance ◽  
Present Systematic Review

There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its use as a prognostic biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. We discuss the pitfalls and challenges that need to be assessed to understand the power of miR-155 to respond to real clinical needs, highlighting the consistency, robustness or lack of results obtained to sate in translating this molecule to clinical practice. Our paper suggests that the prognostic role of miR-155 in the management of BC needs to be further verified.

scholarly journals Assessing the functional role of caspase-8 gene variants in breast cancer

2010 ◽  
Vol 12 (S1) ◽  
Author(s):  
SH Rigas ◽  
M Parry ◽  
MW Reed ◽  
N Camp ◽  
A Cox
Keyword(s):  
Breast Cancer ◽  
Functional Role ◽  
Caspase 8 ◽  
Gene Variants

10. DECODING THE ROLE OF CANCER STEM CELLS IN PROGRESSION OF BREAST CANCER: A PILOT STUDY

2020 ◽  
Vol 46 (6) ◽  
pp. e3-e4
Author(s):  
Diptendra K. Sarkar ◽  
Ayan Pradhan ◽  
Ayush Keshav Singhal
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Pilot Study ◽  
Cancer Stem Cells

scholarly journals Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study

2017 ◽  
Vol 29 (4) ◽  
pp. 191-195 ◽  
Author(s):  
Masoumeh Aghababazadeh ◽  
Najmeh Dorraki ◽  
Fahimeh Afzal Javan ◽  
Asieh Sadat Fattahi ◽  
Masoumeh Gharib ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pilot Study ◽  
Cancer Patients ◽  
Caspase 8 ◽  
Breast Cancer Patients

scholarly journals The Role of lncRNA PCAT6 in Cancers

2021 ◽  
Vol 11 ◽  
Author(s):  
Siying Wang ◽  
Zhenyao Chen ◽  
Jingyao Gu ◽  
Xin Chen ◽  
Zhaoxia Wang
Keyword(s):  
Breast Cancer ◽  
Prognostic Biomarker ◽  
Malignant Tumors ◽  
Vital Role ◽  
Cancer Breast ◽  
Non Coding Rna ◽  
Different Types ◽  
Cancer Côlon ◽  
Long Non Coding Rna

Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors. PCAT6 can promote the development and progression of different types of malignant tumors through various mechanisms. Overall, these findings suggest that PCAT6 may play an increasingly vital role in the clinical assessment of these malignant tumors. It can function as an oncogene and may be used as a potential new prognostic biomarker of these tumors.

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