Background:
Quinoline-containing compounds present in both natural and synthetic products are an
important class of heterocyclic compounds. Many of the substituted quinolines have been used in various areas
including medicine as drugs. Compounds with quinoline skeleton possess a wide range of bioactivities such as
antimalarial, anti-bacterial, anthelmintic, anticonvulsant, antiviral, anti-inflammatory, and analgesic activity.
Due to such a wide range of applicability, the synthesis of quinoline derivatives has attracted a lot of attention
of chemists to develop effective methods. Many known methods have been expanded and improved.
Furthermore, various new methods for quinoline synthesis have been established. This review will focus on
considerable studies on the synthesis of quinolines date which back to 2014.
Objective:
In this review, we discussed recent achievements on the synthesis of quinoline compounds. Some
classical methods have been modified and improved, while other new methods have been developed. A vast
variety of catalysts were used for these transformations. In some studies, quinoline synthesis reaction
mechanisms were also displayed.
Conclusion:
Many methods for the synthesis of substituted quinoline rings have been developed recently. Over
the past five years, the majority of those reported have been based on cycloisomerization and cyclization
processes. Undoubtedly, more imaginative approaches to quinoline synthesis will appear in the literature in the
near future. The application of known methods to natural product synthesis is probably the next challenge in
the field.
3D Structure and Function of Glycosyltransferases Involved in N-glycan Maturation
