Recent Progress in the Synthesis of Quinolines

2019 ◽  
Vol 16 (5) ◽  
pp. 671-708 ◽  
Author(s):  
Duc Dau Xuan
Keyword(s):  
Reaction Mechanisms ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Natural Product Synthesis ◽  
Important Class ◽  
The Past ◽  
New Methods ◽  
Substituted Quinolines ◽  
Wide Range ◽  
Near Future

Background: Quinoline-containing compounds present in both natural and synthetic products are an important class of heterocyclic compounds. Many of the substituted quinolines have been used in various areas including medicine as drugs. Compounds with quinoline skeleton possess a wide range of bioactivities such as antimalarial, anti-bacterial, anthelmintic, anticonvulsant, antiviral, anti-inflammatory, and analgesic activity. Due to such a wide range of applicability, the synthesis of quinoline derivatives has attracted a lot of attention of chemists to develop effective methods. Many known methods have been expanded and improved. Furthermore, various new methods for quinoline synthesis have been established. This review will focus on considerable studies on the synthesis of quinolines date which back to 2014. Objective: In this review, we discussed recent achievements on the synthesis of quinoline compounds. Some classical methods have been modified and improved, while other new methods have been developed. A vast variety of catalysts were used for these transformations. In some studies, quinoline synthesis reaction mechanisms were also displayed. Conclusion: Many methods for the synthesis of substituted quinoline rings have been developed recently. Over the past five years, the majority of those reported have been based on cycloisomerization and cyclization processes. Undoubtedly, more imaginative approaches to quinoline synthesis will appear in the literature in the near future. The application of known methods to natural product synthesis is probably the next challenge in the field.

The chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5- ones as a privileged scaffold in synthesis of heterocycles

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen A.-M. Gomaa ◽  
Huda A. Ali
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Reaction Conditions ◽  
Azacrown Ethers ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Number Of Publications ◽  
Near Future

Background : The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo-imidazoles, - thiazoles, spiropyridines, spiropyrroles, spiropyrans and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule. Objective: This article aims to review the preparation of DCNP, its reactivity and application in heterocyclic and dyes synthesis. Conclusion: In this review we have provided an overview of recent progress in the chemistry of DCNP and its significance in synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.

scholarly journals Innovation in the sphere of advertising: latest innovations and prospects of development

2021 ◽  
Vol 12 (2) ◽  
pp. 140-146
Author(s):  
Мария Олеговна Сураева ◽  
Maria O. Suraeva
Keyword(s):  
Information Technology ◽  
Social Network ◽  
Digital Marketing ◽  
Outdoor Advertising ◽  
The Past ◽  
New Methods ◽  
Contextual Advertising ◽  
Product Value ◽  
Fast Pace ◽  
Near Future

Advertising innovation is growing at a fast pace today. We observe how advertising is becoming more and more digital, it has also become easier to use, now it can be done not only by an agency, but by any person who has one or another category of listeners, an audience in a social network. But it should be noted that digital advertising still does not completely replace outdoor advertising, which has undergone dramatic changes over the past few years: new creative ways of presenting product value to the consumer have appeared, often using information technology. This article discusses the main innovations in the field of digital and outdoor advertising over the past five years, as well as the prospects for their development in the near future. The article reveals new methods of communication between the seller and the client using advertising, the reasons for using contextual advertising (safety, efficiency), reflects how to correctly apply the technologies of innovative types of advertising today and how companies understand what the consumer needs and why they need to focus on social and digital marketing. It also analyzed what factors should be considered when choosing advertising methods.

Recent Progress in the Synthesis of Benzo[b]thiophene

2020 ◽  
Vol 24 (19) ◽  
pp. 2256-2271
Author(s):  
Dau Xuan Duc
Keyword(s):  
Organic Semiconductors ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Medicinal Chemistry ◽  
Building Blocks ◽  
Intensive Research ◽  
Wide Range ◽  
Thiophene Derivatives ◽  
Anti Hiv ◽  
Aromatic Heterocyclic

: Benzo[b]thiophenes are aromatic heterocyclic compounds containing benzene and thiophene rings. This class of heterocycles is present in a large number of natural and non-natural compounds. Benzo[b]thiophene derivatives have a broad range of applications in medicinal chemistry such as antimicrobial, anticancer, antioxidant, anti-HIV and antiinflammatory activities. The use of benzo[b]thiophene derivatives in other fields has also been reported. Various benzo[b]thiophenes compounds have been employed as organic photoelectric materials, while several benzo[b]thiophenes have been used as organic semiconductors. Benzo[b]thiophenes have also been used as building blocks or intermediates for the synthesis of pharmaceutically important molecules. : Due to such a wide range of applicability, the synthesis of benzo[b]thiophene derivatives has attracted intensive research. Numerous mild and efficient approaches for the synthesis of benzo[b]thiophenes have been developed over the years. Different catalysts and substrates have been applied for benzo[b]thiophene synthesis. This review will focus on the studies in the construction of benzo[b]thiophene skeleton, which date back from 2012.

Recent Achievement in the Synthesis of Thiophenes

2020 ◽  
Vol 17 ◽  
Author(s):  
Duc Dau Xuan
Keyword(s):  
Tiaprofenic Acid ◽  
Membered Ring ◽  
Natural Product Synthesis ◽  
Synthetic Methods ◽  
Ring Compounds ◽  
Wide Range ◽  
Drug Synthesis ◽  
Thiophene Derivatives ◽  
Synthetic Approaches ◽  
Near Future

: Thiophene derivatives are aromatic five-membered ring compounds made up of one Sulphur as heteroatom. These compounds are present in a large number of natural and unnatural compounds with valuable bioactivities. Many of them have a wide range of applications in medicinal chemistry such as antimicrobial, anticancer, antiparasitic, anti-inflammatory, and antihypertensive activities. Some of them are famous drugs in the market nowadays such as Cefoxitin, Cephalothin, Cephaloridine, Temocillin, tinoridine, tiaprofenic acid, tenoxicam, suproprofen and Raltitrexed. The use of thiophenes derivatives also has been found in other fields. The application of thiophenes in organic materials thank to their electronic properties has been reported. In organic synthesis, thiophenes also have drawn attention of chemists because of their values as intermediates. The employment of thiophene derivatives in agrochemicals, flavors, and dyes has also been found. Due to diverse applications, the synthesis of thiophene derivatives has attracted a lot of attention. Numerous known synthetic methods such as Gewald and Fiesselmann methods have been modified and improved. Furthermore, a large number of novel synthetic approaches to the synthesis of thiophenes have been developed. This review will focus on considerable studies on the synthesis of thiophenes which date back from 2012. In this review, we discussed recent achievement in the synthesis of thiophene derivatives. Some established methods have been modified and improved, while other novel methods have been discovered. Diverse catalysts were employed for these transformations. In some syntheses, reaction mechanisms were also displayed. Many methods for the synthesis of thiophenes have been developed recently. In the near future, more imaginative approaches for the synthesis of thiophenes will be investigated to improve the efficiency and versatility or to use environmentally friendly and economical procedures. Application to natural product synthesis and drug synthesis is probably the next challenge in the field.

scholarly journals Robotics and Artificial Intelligence in Gastrointestinal Endoscopy: Updated Review of the Literature and State of the Art

2021 ◽  
Author(s):  
Ivo Boškoski ◽  
Beatrice Orlandini ◽  
Luigi Giovanni Papparella ◽  
Maria Valeria Matteo ◽  
Martina De Siena ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Gastrointestinal Endoscopy ◽  
State Of The Art ◽  
Unmet Need ◽  
Diagnostic Techniques ◽  
Review Of The Literature ◽  
The Past ◽  
Wide Range ◽  
Near Future ◽  
Artificial Intelligence Systems

Abstract Purpose of Review Gastrointestinal endoscopy includes a wide range of procedures that has dramatically evolved over the past decades. Robotic endoscopy and artificial intelligence are expanding the horizons of traditional techniques and will play a key role in clinical practice in the near future. Understanding the main available devices and procedures is a key unmet need. This review aims to assess the current and future applications of the most recently developed endoscopy robots. Recent Findings Even though a few devices have gained approval for clinical application, the majority of robotic and artificial intelligence systems are yet to become an integral part of the current endoscopic instrumentarium. Some of the innovative endoscopic devices and artificial intelligence systems are dedicated to complex procedures such as endoscopic submucosal dissection, whereas others aim to improve diagnostic techniques such as colonoscopy. Summary A review on flexible endoscopic robotics and artificial intelligence systems is presented here, showing the m3ost recently approved and experimental devices and artificial intelligence systems for diagnosis and robotic endoscopy.

Recent Advances on Synthesis of 1,4-Benzoxazines and its Derivatives

2021 ◽  
Vol 25 ◽  
Author(s):  
Wei Liang ◽  
Li-Jing Min ◽  
Liang Han ◽  
Xing-Hai Liu
Keyword(s):  
Reaction Mechanisms ◽  
Heterocyclic Compounds ◽  
Synthesis Methods ◽  
Important Class ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Active Structure ◽  
Recent Advances ◽  
The Future

: 1,4-benzoxazine compounds are an important class of heterocyclic compounds. Ever since 1,4-benzoxazine was discovered in 1959, it has attracted chemists due to its unique physiological activities, and their synthesis and application have been studied. However, the traditional synthesis methods of 1,4-benzoxazines have some drawbacks, such as complicated steps, harsh reaction conditions and low yield. Therefore, it is still a significant direction to develop new and efficient synthesis methods. In this paper, the synthesis methods and reaction mechanisms of these compounds are reviewed, and the application prospect of 1,4- benzoxazine and its derivatives as a dominant active structure in the future is discussed.

An overview of the synthetic route to the marketed formulations of pyrimidine: A Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Amit Kumar ◽  
Ankit Siwach ◽  
Prabhakar Verma
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
New Work ◽  
Important Class ◽  
Synthetic Route ◽  
Antiprotozoal Activity ◽  
Pyrimidine Derivatives ◽  
Organic Reaction ◽  
Wide Range ◽  
Pyrimidine Moiety

: Pyrimidine and its derivatives are a very important class of heterocyclic compounds that show interesting applications in the field of medicinal chemistry. Pyrimidine not only plays an important role as an organic reaction intermediate but also has a wide range of interesting biological activities viz. antibacterial, antifungal, anticancer, anti-inflammatory, antiviral, and antiprotozoal activity, etc. Numerous methods are available for the formation of pyrimidine derivatives have been reported in the literature. The advantage of pyrimidine as a starting material for different therapeutically potent derivatives has given momentum to this research. This review aims to report the new work on the synthesis of marketed drugs which consist of pyrimidine moiety.

Recent Progress in the Synthesis of Isoxazoles

2021 ◽  
Vol 25 ◽  
Author(s):  
Dau Xuan Duc ◽  
Vo Cong Dung
Keyword(s):  
High Temperature ◽  
Nitrogen Atom ◽  
Oxygen Atom ◽  
Organic Synthesis ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Membered Ring ◽  
Wide Range ◽  
Anticonvulsant Activities ◽  
Isoxazole Derivatives

: Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad spectrum of applications in medicinal chemistry, such as antimicrobial, anticancer, antitumor, antitubercular, analgesic, anti-inflammatory, antidepressant, and anticonvulsant activities and some of them are well-known drugs for the treatment of various diseases in the market. The use of this class of compounds in agriculture as herbicides, insecticides have been widely reported. In organic materials, these compounds have been applied as semiconductors, single-walled nanotubes, liquid crystals, chiral ligands, scaffolds for peptidomimetics, dyes, and high-temperature lubricants. Isoxazole derivatives also play an important role in organic synthesis because they can be converted into several important synthetic units such as β-hydroxy ketones, γ-amino alcohols, α,β-unsaturated oximes, β-hydroxy nitriles, α-hydroxy-β-diketones, and β-dicarbonyl compounds. Due to such a wide range of applicability, the synthesis of isoxazole derivatives has attracted intensive research from chemists. This review will focus on considerable studies on the synthesis of isoxazoles which date back from 2012.

Sandwich complexes of naphthalocyanine with the rare earth metals

2003 ◽  
Vol 07 (07) ◽  
pp. 459-473 ◽  
Author(s):  
Jianzhuang Jiang ◽  
Wei Liu ◽  
Dennis P. Arnold
Keyword(s):  
Rare Earth ◽  
Recent Progress ◽  
Rare Earth Metals ◽  
Electron System ◽  
Current Status ◽  
Important Class ◽  
Sandwich Complexes ◽  
The Past ◽  
Significant Research ◽  
Sandwich Type

Over the past two decades and in particular the past five years, numerous sandwich-type rare earth complexes containing naphthalocyanine ligands have been synthesized. The more extended delocalized π-electron system of naphthalocyanine in comparison with phthalocyanine generates unique physical, spectroscopic, electrochemical and photoelectrochemical properties which have aroused significant research interest in these compounds. This review summarizes recent progress in research on this important class of molecular materials and overviews the current status of the field.

Recent Progress in the Synthesis of Pyrroles

2020 ◽  
Vol 24 (6) ◽  
pp. 622-657
Author(s):  
Duc Dau Xuan
Keyword(s):  
Biological Activity ◽  
Organic Semiconductors ◽  
Broad Spectrum ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Biological Activities ◽  
Antibacterial Activities ◽  
Synthetic Methods ◽  
Pyrrole Derivatives ◽  
Wide Range

: Pyrrole derivatives are nitrogen-containing heterocyclic compounds and widely distributed in a large number of natural and non-natural compounds. These compounds possess a broad spectrum of biological activities such as anti-infammatory, antiviral, antitumor, antifungal, and antibacterial activities. Besides their biological activity, pyrrole derivatives have also been applied in various areas such as dyes, conducting polymers, organic semiconductors. : Due to such a wide range of applicability, access to this class of compounds has attracted intensive research interest. Various established synthetic methods such as Paal-Knorr, Huisgen, and Hantzsch have been modified and improved. In addition, numerous novel methods for pyrrole synthesis have been discovered. This review will focus on considerable studies on the synthesis of pyrroles, which date back from 2014.

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