scholarly journals Association between psychotropic drug use and handgrip strength in older hospitalized patients

2021 ◽  
Author(s):  
Miriam Kristine Sandvik ◽  
Leiv Otto Watne ◽  
Anniken Brugård ◽  
Marte Sofie Wang-Hansen ◽  
Hege Kersten
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Handgrip Strength ◽  
Threshold Value ◽  
Hospitalized Patients ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Linear Character ◽  
Psychotropic Drug Use

Abstract Purpose Handgrip strength is an indicator of frailty and longevity in older adults. The association between psychotropic drug use and handgrip strength in older hospitalized patients was investigated in this study. Methods A total of 488 patients were included in this retrospective cross-sectional study, 333 women and 155 men, from two different cohorts of older (mean age 84 years) hospitalized in-patients. We used multiple linear regression models to explore the association between psychotropic drug use and handgrip strength. We adjusted for factors known to affect handgrip strength: Age, gender, body mass index (BMI) and comorbidity (Charlson comorbidity index). Results Both unadjusted and adjusted analyses showed that psychotropic drug use was associated with handgrip strength (β = − 0.183, p < 0.0001). The relationship was of a linear character, with no clear threshold value, but with the greatest reduction in handgrip strength between zero and two psychotropic drugs. Conclusion An increasing number of psychotropic drugs were significantly associated with reduced handgrip strength in a linearly pattern. Hence, it is timely to question the guided threshold value of avoidance of three or more psychotropic drugs in older people. Psychotropic drug use should be kept as low as possible in treatment of older patients.

scholarly journals Change in psychotropic drug use among community-dwelling people aged 75 years and older in Finland: repeated cross-sectional population studies

2011 ◽  
Vol 23 (8) ◽  
pp. 1278-1284 ◽  
Author(s):  
Franciska Desplenter ◽  
Charlotte Caenen ◽  
Jolein Meelberghs ◽  
Sirpa Hartikainen ◽  
Raimo Sulkava ◽  
...  
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Adverse Drug Events ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Psychotropic Drug Use ◽  
Random Samples ◽  
Antidepressant Use ◽  
Status Differences ◽  
Compare And Contrast

ABSTRACTBackground: Older people are at high risk of experiencing psychotropic-related adverse drug events. The objective of this study was to compare and contrast the use of psychotropic drugs among community-dwelling people aged ≥75 years in 1998 and 2004.Methods: Comparable random samples of people aged ≥75 years were extracted from the population register in Kuopio, Finland, in 1998 (n = 700) and 2003 (n = 1000). In 1998 and 2004, 523 and 700 community-dwelling people respectively participated in nurse interviews, during which demographic, diagnostic and drug use data were elicited. Logistic regression was used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of psychotropic drug use in 2004 compared to 1998.Results: The unadjusted prevalence of total psychotropic (37.3% and 38.4%, OR 1.05; 95% CI 0.83–1.33), anxiolytic, hypnotic and sedative (29.6% and 31.3%, OR 1.08, 95% CI 0.85–1.38), and antidepressant (10.7% and 11.9%, OR 1.12, 95% CI 0.78–1.61) use were similar in 1998 and 2004. There was a decrease in the unadjusted prevalence of antipsychotic use (9.2% and 5.7%, OR 0.60; 95% CI 0.39–0.93). After adjusting for socioeconomic and health status differences, there was an increase in the prevalence of total psychotropic (adjusted OR 1.31, 95% CI 1.01–1.70) and antidepressant (OR 1.59, 95% CI 1.06–2.40) use.Conclusion: The unadjusted prevalence of psychotropic drug use remained stable between 1998 and 2004. However, in adjusted analyses there was a small increase in the prevalence of any psychotropic drug use and antidepressant use specifically.

Use of Psychotropic Drugs in Gynecological, Surgical, and Medical Wards of General Hospitals

1998 ◽  
Vol 28 (3) ◽  
pp. 303-314 ◽  
Author(s):  
J. Wancata ◽  
N. Benda ◽  
U. Meise ◽  
C. Müller
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychiatric Illness ◽  
Psychiatric Morbidity ◽  
Older Age ◽  
Sociodemographic Characteristics ◽  
General Hospitals ◽  
Psychotropic Drug Use ◽  
Medical Wards

Objective: The purpose of the present study was to investigate the prevalence of psychotropic drug use and the predictors of use during hospitalization. Method: We investigated 728 patients admitted to medical, gynecological, and surgical wards of two non-university general hospitals in Austria for psychotropic drug use, psychiatric morbidity, and sociodemographic characteristics. Results: The use of psychotropics was highest in medical wards (67.6%), followed by surgical (59.3%), and gynecological wards (37.8%). Older age, psychiatric caseness, consultation by psychiatrists and use of psychotropics before admission were predictors for psychotropic drug use. Psychotropics were given for a longer duration to psychiatric cases than to non-cases. Anxiolytics were prescribed most often (39.6%), followed by hypnotics (16.9%), neuroleptics (10.7%), and antidepressants (7.0%). Conclusions: The fact that psychiatric illness is a significant predictor of psychotropic drug use suggests that these drugs were prescribed aptly. The longer duration of use among psychiatric cases supports the idea of appropriate prescriptions.

Prevalence and correlates of psychotropic drug use in community-dwelling people with young-onset dementia: the NeedYD-study

2014 ◽  
Vol 26 (12) ◽  
pp. 1983-1989 ◽  
Author(s):  
Raymond T.C.M. Koopmans ◽  
Renate Reinders ◽  
Deliane van Vliet ◽  
Frans R.J. Verhey ◽  
Marjolein E. de Vugt ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Unmet Needs ◽  
Community Dwelling ◽  
Young Onset ◽  
Disease Awareness ◽  
Psychotropic Drug Use ◽  
Young Onset Dementia

ABSTRACTBackground:Young-onset dementia (YOD) is defined as dementia that develops before the age of 65 years. The prevalence and type of neuropsychiatric symptoms (NPS) in YOD differ from patients with late onset dementia. NPS in dementia patients are often treated with psychotropic drugs. The aim of this study was to investigate psychotropic drug use (PDU) in Dutch community-dwelling YOD patients and the association between age, gender, dementia etiology and severity, symptoms of depression, disease awareness, unmet needs, and type of NPS.Methods:Psychotropic drug use in 196 YOD patients was registered. Drugs were categorized according to the Anatomical Therapeutical Chemical classification. The association between age, gender, dementia type, dementia stage, type of NPS, depressive symptoms, disease awareness, and amount of unmet needs on total PDU was analyzed using binomial logistic regression analysis.Results:Fifty-two percent of the patients were prescribed at least one psychotropic drug; 36.2% of patients used one drug, and 12.2% used two different drugs. Antidepressants (36.2%) and antipsychotic drugs (17.3%) were the most frequently prescribed psychotropic drugs. Anti-dementia drugs were prescribed in 51.5% of the patients. Increasing age and moderate to severe depressive symptoms were positively associated with the total use of psychotropic drugs.Conclusions:Community-dwelling YOD patients have a high prevalence of PDU. More research is needed to study the association between unmet needs, NPS, and PDU, and psychosocial interventions have to be developed to limit the use of psychotropic drugs in YOD.

Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals

2020 ◽  
Vol 53 (03) ◽  
pp. 133-137
Author(s):  
Julia C. Stingl ◽  
Katja S. Just ◽  
Marlen Schurig ◽  
Miriam Böhme ◽  
Michael Steffens ◽  
...  
Keyword(s):  
Older Adults ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Adverse Drug Reactions ◽  
Psychotropic Drugs ◽  
Drug Users ◽  
Prospective Observational Study ◽  
Drug Reactions ◽  
Specific Patient ◽  
Psychotropic Drug Use

Abstract Introduction The prevalence of psychotropic drug use in our society is increasing especially in older adults, thereby provoking severe adverse drug reactions (ADR). To identify specific patient risk profiles associated with psychotropic drug use in the situation of polymedication. Methods Cases of ADRs in general emergency departments (ED) collected within the multi-center prospective observational study (ADRED) were analyzed (n=2215). We compared cases with use of psychotropic drugs and without concerning their clinical presentation at the ED. Results A third of patients (n=731, 33%) presenting to the ED with an ADR took at least 1 psychotropic drug. Patients with psychotropic drug use tended to be older, more often female, and took a higher number of drugs (all p<0.001). The frequency of falls was almost 3 times higher than compared to the non-psychotropic drug group (10.5 vs. 3.9%, p<0.001), and similar syncope was also more often seen in the psychotropic drug users (8.8 vs. 5.5%, p=0.004). The use of psychotropic drugs increased the risk for falls by a factor of 2.82 (OR, 95% CI (1.90–4.18)), when adjusting for gender, age, numbers of pre-existing diseases, and drugs, respectively. Discussion The association of psychotropic drug use with fall and syncope in combination with polymedication and older age leads to the suspicion that psychotropic drugs might be potentially harmful in specific risk populations such as older adults. It may lead us to thoroughly weigh the benefit against risk in a patient-oriented way, leading to an integrative personalized therapy approach.

Self-reported psychotropic drug use and associated factors in a French community sample

1992 ◽  
Vol 22 (1) ◽  
pp. 181-190 ◽  
Author(s):  
P. Pariente ◽  
J. P. Lépine ◽  
J. Lellouch
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Community Sample ◽  
Age Groups ◽  
Household Survey ◽  
Well Being ◽  
Cross Sectional ◽  
Logistic Analysis ◽  
Psychotropic Drug Use ◽  
History Of

SYNOPSISDrug use was examined in a French general population adult sample from a household survey conducted in 1987–8 in a newly built town near Paris. Psychotropic drug use was measured by the percentage of subjects reporting their use during the past week. It was prominently represented by benzodiazepines (90% of psychotropic users), differed strongly between genders (4·6% in men, 10·2% in women) and age groups (higher after 40 years). A lifetime history of major depressive episode (MDE) or of anxiety disorders was associated with a higher proportion of psychotropic drug use. Psychotropic drug use also went with a current well-being questionnaire score. Using a logistic analysis, the following set of variables held for women: well-being score, history of both MDE and anxiety disorder, age, and marital status. Making allowance for the cross-sectional nature of this retrospective survey, these finding confirmed the relatively high level of benzodiazepine drug use in an urban French community sample and emphasized its association with mental health status.

Psychotropic drug use in relation to mental disorders and institutionalization among 95-year-olds: a population-based study

2011 ◽  
Vol 23 (8) ◽  
pp. 1270-1277 ◽  
Author(s):  
Eva Lesén ◽  
Anders Carlsten ◽  
Ingmar Skoog ◽  
Margda Waern ◽  
Max Petzold ◽  
...  
Keyword(s):  
Drug Use ◽  
Mental Disorders ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychotic Disorders ◽  
Rating Scale ◽  
The Elderly ◽  
Population Based ◽  
Prescribing Patterns ◽  
Psychotropic Drug Use

ABSTRACTBackground: The prevalence of psychotropic drug use is high among the elderly, but research on how psychotropic drugs are used among individuals aged 90 years and older is limited. An increased knowledge on this topic may contribute to improved prescribing patterns in this vulnerable population. The aim of this study was to assess the use of psychotropic drugs in relation to mental disorders and institutionalization among 95-year-olds and to identify use of potentially inappropriate psychotropic drugs.Methods: All 95-year-olds born in 1901–1903 living in nursing homes or community settings in Gothenburg, Sweden were invited to participate. The response rate was 65% and 338 95-year-olds were examined (263 women, 75 men). Psychotropic drug use in relation to mental disorders and institutionalization was assessed. Information on drug use was collected primarily from multi-dose drug dispensing lists. Participants were examined by trained psychiatrists using the Comprehensive Psychopathological Rating Scale and a battery of cognitive tests. Dementia, depression, anxiety and psychotic disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (DSM-III-R).Results: Sixty percent of the 95-year-old participants used psychotropic drugs; hypnotics were most common (44%). Potentially inappropriate psychotropics were observed in one third (33%). Antidepressants were used by 7% of the participants without dementia who fulfilled criteria for a depressive disorder, while 56% used hypnotics and 30% used anxiolytics.Conclusions: The high prevalence of psychotropic drug use and the nonspecific nature of these treatments among 95-year-olds indicate a need for improvement in prescribing patterns.

Utilization of Psychotropic Drugs in Saskatchewan: 1977–1980

1983 ◽  
Vol 28 (7) ◽  
pp. 547-551 ◽  
Author(s):  
Bob Power ◽  
Winanne Downey ◽  
Bruce R. Schnell
Keyword(s):  
Drug Use ◽  
Drug Utilization ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Entire Population ◽  
Sample Surveys ◽  
Psychotropic Drug Use ◽  
Drug Utilization Studies ◽  
Combination Analgesics

Psychotropic drug use in Saskatchewan during 1977, 1978, 1979 and 1980 was determined. Approximately one in five prescriptions dispensed was for a psychotropic. About 20% of the population received psychotropic drugs in each year but use has declined slightly, especially that of tranquilizers. Psychotropic use increased with the patient's age and nearly two-thirds were women. Considerable caution should be exercised in making comparisons with other drug utilization studies. There may be substantial differences in the drugs selected for study, the categorization of these drugs, and the methodology used to analyze drug use. Also, most studies are based on data that is from a decade old or older. Moreover, most if not all other studies on drug use are based on sample surveys (from different sampling universes), whereas the present study is based on the entire population. Nevertheless, some generalizations may be valid. Since non-formulary drugs are excluded, the findings should be regarded as conservative. Examples of non-formulary drugs considered to be psychotropic include antispasmodic / tranquilizer / sedative combinations (example: Librax, Donnatal), combination hypnotics (example: Tuinal, Mandrax), and some combination analgesics (example: propoxyphene compounds, pentazocine compound, oxycodone compound).

Only 10% of the psychotropic drug use for neuropsychiatric symptoms in patients with dementia is fully appropriate. The PROPER I-study

2016 ◽  
Vol 28 (10) ◽  
pp. 1589-1595 ◽  
Author(s):  
Klaas van der Spek ◽  
Debby L. Gerritsen ◽  
Martin Smalbrugge ◽  
Marjorie H. J. M. G. Nelissen-Vrancken ◽  
Roland B. Wetzels ◽  
...  
Keyword(s):  
Nursing Home ◽  
Drug Use ◽  
Psychotropic Drug ◽  
Neuropsychiatric Symptoms ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Inappropriate Use ◽  
Psychotropic Drug Use ◽  
Nursing Home Patients ◽  
Sum Score

ABSTRACTBackground:This study explores the appropriateness of psychotropic drug (PD) use for neuropsychiatric symptoms (NPS) in nursing home patients with dementia.Methods:A cross-sectional study on 559 patients with dementia residing on dementia special care units in Dutch nursing homes was conducted. Appropriateness of PD use was assessed using the Appropriate Psychotropic drug use In Dementia (APID) index. The APID index score is calculated using information about individual PDs from patients’ medical records. The index encompasses seven (different) domains of appropriateness, i.e. indication, evaluation, dosage, drug-drug interactions, drug-disease interactions, duplications, and therapy duration.Results:A total of 578 PDs were used for NPS by 60% of the nursing home patients. Indication, evaluation, and therapy duration contributed the most to inappropriate use. Ten per cent of the PDs scored fully appropriate according to the APID index sum score, 36% scored fully appropriate for indication, 46% scored fully appropriate for evaluation, and 58% scored fully appropriate for therapy duration. Antidepressants were used the most appropriately, and antiepileptics the most inappropriately.Conclusions:The minority of the PD use was fully appropriate. The results imply that PD use for NPS in dementia can be improved; the appropriateness should be optimized with a clinical focus on the appropriate indications, evaluations, and therapy duration.

The effects of medication assessment on psychotropic drug use in the community-dwelling elderly

2010 ◽  
Vol 23 (3) ◽  
pp. 473-484 ◽  
Author(s):  
Maria Rikala ◽  
Maarit Jaana Korhonen ◽  
Raimo Sulkava ◽  
Sirpa Hartikainen
Keyword(s):  
Drug Use ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Intervention Group ◽  
Community Dwelling ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Psychotropic Drug Use ◽  
And Control

ABSTRACTBackground:The study evaluated the effects of an annual medication assessment conducted as part of a Comprehensive Geriatric Assessment (CGA) on the prevalence of psychotropic drug use in community-dwelling elderly people.Methods:Randomly selected persons (n = 1000) aged ≥75 years living in the city of Kuopio, Finland were randomized to intervention and control groups. The intervention group underwent an annual (2004–2006) medication assessment as part of a CGA by physicians. Data on drug use were gathered by interviews at baseline (2004) and in three following years (2005–2007). Generalized estimating equations (GEE) were applied to explore whether the prevalence of psychotropic drug use differed between the community-dwelling participants of the intervention (n = 361) and control groups (n = 339) over time.Results:At baseline, nearly 40% of the participants used psychotropic drugs in each group. In the intervention group, the study physicians implemented 126 psychotropic drug-related changes, 39% of which were persistent after one year. The prevalence of use of psychotropic drugs, antipsychotics and anxiolytic/hypnotics did not differ between the groups over time. The prevalence of antidepressant use remained constant in the intervention group, but increased in the control group (p-value for interaction = 0.039). The prevalence of concomitant use of psychotropic drugs decreased non-significantly in the intervention group, but increased in the control group (p-value for interaction = 0.009).Conclusions:Conducting an annual medication assessment outside the usual primary health care system does not appear to reduce the prevalence of psychotropic drug use in community-dwelling elderly people. However, it may prevent concomitant use of psychotropic drugs.

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