scholarly journals Investigator Initiated Clinical Trials (IICTs): A Systematic Search in Registries to Compare the Czech Republic and Portugal in Terms of Funding Policies and Scientific Outcomes

2021 ◽  
Author(s):  
C. Madeira ◽  
L. Hořavová ◽  
F. dos Santos ◽  
J. R. Batuca ◽  
K. Nebeska ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Czech Republic ◽  
Clinical Research ◽  
Systematic Search ◽  
European Countries ◽  
The Czech Republic ◽  
Research Outcomes ◽  
Funding Policies ◽  
Funding Agencies ◽  
First Time

Abstract Objectives Clinical trials provide one of the highest levels of evidence to support medical practice. Investigator initiated clinical trials (IICTs) answer relevant questions in clinical practice that may not be addressed by industry. For the first time, two European Countries are compared in terms of IICTs, respective funders and publications, envisaging to inspire others to use similar indicators to assess clinical research outcomes. Methods A retrospective systematic search of registered IICTs from 2004 to 2017, using four clinical trials registries was carried out in two European countries with similar population, GDP, HDI and medical schools but with different governmental models to fund clinical research. Each IICT was screened for sponsors, funders, type of intervention and associated publications, once completed. Results IICTs involving the Czech Republic and Portugal were n = 439 (42% with hospitals as sponsors) and n = 328 (47% with universities as sponsors), respectively. The Czech Republic and Portuguese funding agencies supported respectively 61 and 27 IICTs. Among these, trials with medicinal products represent 52% in Czech Republic and 4% in Portugal. In the first, a higher percentage of IICTs’ publications in high impact factor journals with national investigators as authors was observed, when compared to Portugal (75% vs 15%). Conclusion The better performance in clinical research by Czech Republic might be related to the existence of specific and periodic funding for clinical research, although further data are still needed to confirm this relationship. In upcoming years, the indicators used herein might be useful to tracking clinical research outcomes in these and other European countries.

scholarly journals Investigator initiated clinical trials (IICTs): a systematic search in registries comparing Czech Republic and Portugal in terms of funding policies and scientific outcomes

2020 ◽  
Author(s):  
Catarina Madeira ◽  
Lenka Hořavová ◽  
Francisco dos Santos ◽  
Joana Batuca ◽  
Katerina Nebeska ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Czech Republic ◽  
Clinical Research ◽  
Systematic Search ◽  
European Countries ◽  
Level Of Evidence ◽  
Funding Policies ◽  
Funding Agencies ◽  
National Performance ◽  
Health Research Council

Abstract Background: Clinical trials provide one of the highest level of evidence to support medical practice. Investigator initiated clinical trials (IICTs) answer relevant questions in clinical practice that may not be addressed by industry. This study aims to compare, for the first time, two European Countries in terms of registered IICTs, respective funders, scientific outcome and its impact on the national performance in IICTs. Methods: A retrospective systematic search of registered IICTs, over the past 13 years, using four clinical trials registries was carried out in two European countries with similar population and Gross Domestic Product (GDP) but with different governmental models to fund clinical research. Each completed IICT was screened for sponsors, funders, type of intervention and associated publications. Results: IICTs involving Czech Republic and Portugal were n=439 (42 % with hospitals as sponsors) and n=328 (47 % with universities as sponsors), respectively. Funding agencies (national and international) supported only 25 % and 18 % of the IICTs in Czech Republic and Portugal, respectively. The Czech Ministry of Health, through the Health Research Council, supported 61 IICTs and the Portuguese Ministry of Science, Technology and High Education, through Fundação para a Ciência e Tecnologia , supported 27 IICTs. Among these, trials with investigational medicinal products represent 52 % (n= 32/61) and 4 % (n=1/27) in Czech Republic and Portugal, respectively. The Czech Republic presented a higher percentage of IICTs´ publications in high impact factor journals (IF>21) with national investigators as authors, when compared to Portugal (86 % vs 15 %). Conclusion: We found a better performance of Czech Republic in terms of number and scientific outcome of IICTs when compared to Portugal. These findings might be related to the existence of specific and periodic funding for clinical research in Czech Republic, although further data still need to be collected to confirm this relationship.

INTERNATIONAL GRANT COOPERATION AS A TOOL FOR THE DEVELOPMENT OF PROFESSIONAL COMPETENCIES OF UNIVERSITY TEACHERS

2018 ◽  
pp. 4-8
Author(s):  
Milan Chmura
Keyword(s):  
Higher Education ◽  
Czech Republic ◽  
Professional Education ◽  
European Countries ◽  
International Project ◽  
The Czech Republic ◽  
University Teachers ◽  
Quality Of Higher Education ◽  
Education And Development

The education and development of university teachers have its justifcation and its importance is signifcant not only in the Czech Republic but also abroad. This study provides an analysis of further professional education of university teachers in the Czech Republic and in selected European countries. Subsequently, it presents an international project with participants from the Czech Republic, Ukraine, Slovakia and Poland, which, ultimately, plays a role in the improvement of the quality of higher education.

A Mistrustful Society?

2020 ◽  
Vol 10 (2) ◽  
pp. 52-71
Author(s):  
Nicole Horáková
Keyword(s):  
Czech Republic ◽  
Empirical Data ◽  
European Countries ◽  
Eastern European ◽  
The Czech Republic ◽  
State Institutions ◽  
Government Institutions ◽  
European Values ◽  
European Values Study ◽  
Eastern European Countries

The level of trust in politicians also in government institutions is taken as an indicator of the state of society in general. Various studies have shown that the population of the Central Eastern European countries, and especially the citizens of the Czech Republic, lack trust in state institutions and democratic structures. The trust of the Czech population in government institutions is, compared to other (Western) European countries, at a relatively low level. This article aims to discuss different factors that are currently influencing this lack of trust: the historical, cultural, and institutional. The empirical data for this article is based on the European Values Study and Czech surveys of public opinion concerning trust in government institutions.

A Comparative Analysis of the Power of Selected European Countries. The Economic Determinants

2021 ◽  
Vol 37 (37) ◽  
pp. 22-42
Author(s):  
Alicja Paluch ◽  
Henryk Spustek
Keyword(s):  
Czech Republic ◽  
Comparative Analysis ◽  
European Countries ◽  
Economic Power ◽  
Strongly Correlated ◽  
The Czech Republic ◽  
Independent Variables ◽  
Economic Sphere ◽  
National Power

The ever-increasing need for in-depth analysis and quantification of the national power, in particular ‘hard’ and ‘soft’ power-generating factors as well as difficulties in identifying a comprehensive and effective method for scientific determination of the national power, have given rise to research in the indicated scientific issues within this article. The presented considerations aim to define the assumptions for a descriptive sub-model that would enable a comparison of Poland’s power in the economic sphere (which is a component of the non-military sphere) with the power of selected European countries. The research hypothesis is that, among the variety of descriptive variables in the economic sphere of the national power, there is a subset of mutually independent variables, at the same time strongly correlated with the national power, which make it possible to define assumptions for the sub-model of the national power. The steps of the research procedure were carried out using the method of system analysis (multi-criteria comparative analysis) and statistical analysis. The research activities undertaken have shown that the factors that are strongly correlated with the national power in the economic area of the European countries adopted for the analysis are: dynamics of industrial production, private sector credit flows and economic freedom index. The comparative analysis carried out demonstrates that the greatest increase in the economic power in the analysed period took place in Germany (0.68). Slightly smaller growth was recorded in the Czech Republic (0.62) and Poland (0.60), while the lowest value of increase was in Romania (0.23). The conducted qualitative comparative analysis of the economic power of selected European countries allowed to conclude that the independent variables identified are crucial for the formation of the economic power of the analysed countries. At the same time, a fairly strong position of the Czech Republic and Poland in relation to the economic power of Germany was found. The performed quantification of the economic power of the European countries provides a basis for the correct determination of changes in the power distribution of political units, assessment of the power and resources held by the state.

scholarly journals New records of Anthomyiidae (Diptera) from the Czech Republic and Slovakia

2015 ◽  
Vol 64 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Olga Komzáková ◽  
Verner Michelsen
Keyword(s):  
Czech Republic ◽  
New Records ◽  
The Czech Republic ◽  
The Family ◽  
First Time

Abstract Althogether 17 species of the family Anthomyiidae (Diptera) are recorded from the Czech Republic (or Moravia and Bohemia) (16 species) and Slovakia (1 species) for the first time. The most interesting findings are Delia dovreensis Ringdahl 1954 and northamerican species Pegomyia bifurcata Griffiths 1983.

scholarly journals Unusual Occurrence of Salmonella Mikawasima in 2012–2013 in the Czech Republic: Part of a Multistate Outbreak?

2014 ◽  
Vol 63 (3) ◽  
pp. 355-357 ◽  
Author(s):  
PETRA MYŠKOVÁ ◽  
RENÁTA KARPÍŠKOVÁ
Keyword(s):  
Czech Republic ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Antimicrobial Susceptibility Testing ◽  
European Countries ◽  
Quinolone Resistance ◽  
Environmental Isolates ◽  
The Czech Republic ◽  
Unusual Occurrence ◽  
Microbial Agents

An increased number of cases of salmonellosis caused by the rare serotype Mikawasima was noted in the years 2012 and 2013 in the Czech Republic. A potential on-going outbreak caused by this serotype in European countries has also been reported. Altogether 14 human and 1 environmental isolates from the year 2012 and 11 human isolates from the year 2013 from different locations of the Czech Republic were sent to our laboratory for typing. Macrorestriction analysis together with antimicrobial susceptibility testing and PCR for ESBL and plasmid-mediated quinolone resistance detection were performed to compare our isolates. Twenty-one isolates created two very similar clusters and 5 isolates had different profiles. Twenty-five isolates were fully susceptible to all agents used. One isolate showed resistance to 12 microbial agents and possessed blaTEM, blaSHV, blaOXA, blaCTX-M and qnrB genes.

scholarly journals Synanthedon mesiaeformis (Herrich-Schäffer) new to the Czech Republic and to Spain (Lepidoptera: Sesiidae)

2008 ◽  
Vol 56 (5) ◽  
pp. 141-146 ◽  
Author(s):  
Zdeněk Laštůvka ◽  
Aleš Laštůvka
Keyword(s):  
Czech Republic ◽  
Close Contact ◽  
Morphological Characters ◽  
Habitat Requirements ◽  
Specific Population ◽  
The Czech Republic ◽  
Southern France ◽  
History Of ◽  
First Time ◽  
The Town

Synanthedon mesiaeformis (Herrich-Schäffer, 1846) has been found in the Czech Republic and in Spain for the first time. The species was found in the south-easternmost part of the Czech Republic, near the town of Břeclav (faunistic quadrat 7267) in May 2008. The holes and pupae were found only in one, solitary growing group of trees about 20 years old. This finding place lies at a distance of more than 250 km from the localities in SW Hungary and about 550 km from the localities in eastern Poland. In June 2008, the species was found also in alders growing in the flat river alluvium on gravel sands between La Jonquera and Figueres in northern Catalonia. This locality is in a close contact with the fin­ding places near Perpignan and Beziers in southern France. The diagnostic morphological characters and bionomics of this species are briefly summarized and figured. The history of its distribution research is recapitulated and the causes of its disjunct range are discussed as follows. The present disjunct range represents a residual of the former distribution over the warmer and moister postglacial period; landscape modifications and elimination of solitary alder trees as „weeds“ from the 18th up to the mid-20th century in large areas of Europe; narrow and partly unknown habitat requirements and specific population ethology; an insufficient level of faunistic investigations in several parts of sou­thern and eastern Europe.

scholarly journals Obstacles in conducting clinical trials in the Saudi Arabia

2017 ◽  
Vol 4 (4) ◽  
pp. 166
Author(s):  
Salem D. Al Suwaidan ◽  
Aseel S. Alsuwaidan
Keyword(s):  
Clinical Trials ◽  
Saudi Arabia ◽  
Clinical Practice ◽  
Clinical Research ◽  
Strategic Plan ◽  
Good Clinical Practice ◽  
European Countries ◽  
Regulatory Authorities ◽  
Research Institution

<p class="abstract"><strong>Background:</strong> Conducting clinical research in accordance with the standards of regulatory authorities and within the guidelines of the good clinical practice (GCP) is a matter of concern.  It has been noticed that some increment in the conduction of clinical trials outside USA and European countries in the last two decades. The main objective of this study is to identify the magnitude of some obstacles that affect the conduction of clinical trials in accordance with the GCP.</p><p class="abstract"><strong>Methods:</strong> Developing questionnaire in accordance with the criteria of the GCP would make assessment on how to buildup infrastructure including policy and procedures of the research institution. Recommendation of the study is to perform this questionnaire every other year to assess the progress and development of the research institution.</p><p><strong>Conclusions:</strong> To identify good clinical researchers, what sort of obstacle(s) regarding conducting clinical trials, and from these obstacles how to resolve it and build up infrastructure for the research institution and also to establish the strategic plan for the research institution.</p>

scholarly journals The Attractiveness of Selected Central European Countries for Winter Sports and Mountain Hiking

Turyzm ◽  
2018 ◽  
Vol 28 (1) ◽  
pp. 35-40
Author(s):  
Kinga Krzesiwo ◽  
Kamila Ziółkowska-Weiss ◽  
Michał Żemła
Keyword(s):  
Czech Republic ◽  
Mass Scale ◽  
European Countries ◽  
Mountainous Areas ◽  
Winter Sports ◽  
The Czech Republic ◽  
Central European ◽  
Downhill Skiing ◽  
Visegrad Group

Abstract Hiking, downhill skiing and snowboarding are among the most popular forms of active tourism in mountainous areas. Their popularity and their mass scale do not only result from the presence of the appropriate landscape, but also from its appropriate development. The objective of the article is to attempt to assess the attractiveness of selected Central European countries in terms of winter sports and mountain hiking, to consider the opinions of students who live in Visegrad Group countries, as well as to evaluate the barriers to development of their competitive offers. According to respondents, the most attractive countries for winter sports are Austria and Slovakia, and the least attractive are Hungary, Romania and Lithuania. In turn, according to the students, the best conditions for mountain hiking are in Slovakia, Austria, the Czech Republic and Poland. In addition, respondents from particular countries assessed domestic offers highly.

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