scholarly journals Paving New Roads Towards Biodiversity-Based Drug Development in Brazil: Lessons from the Past and Future Perspectives

2021 ◽  
Author(s):  
Fernão Castro Braga
Keyword(s):  
Drug Development ◽  
Future Perspectives ◽  
The Past

Integrating Bioinformatics Strategies in Cancer Immunotherapy: Current and Future Perspectives

2020 ◽  
Vol 23 (8) ◽  
pp. 687-698 ◽  
Author(s):  
Houda N. Washah ◽  
Elliasu Y. Salifu ◽  
Opeyemi Soremekun ◽  
Ahmed A. Elrashedy ◽  
Geraldene Munsamy ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Therapeutic Potential ◽  
Cell Cancer ◽  
Full Potential ◽  
Future Perspectives ◽  
The Past ◽  
Bioinformatics Tools ◽  
Treatment Paradigm ◽  
Immunotherapy Of Cancer ◽  
Significant Attention

For the past few decades, the mechanisms of immune responses to cancer have been exploited extensively and significant attention has been given into utilizing the therapeutic potential of the immune system. Cancer immunotherapy has been established as a promising innovative treatment for many forms of cancer. Immunotherapy has gained its prominence through various strategies, including cancer vaccines, monoclonal antibodies (mAbs), adoptive T cell cancer therapy, and immune checkpoint therapy. However, the full potential of cancer immunotherapy is yet to be attained. Recent studies have identified the use of bioinformatics tools as a viable option to help transform the treatment paradigm of several tumors by providing a therapeutically efficient method of cataloging, predicting and selecting immunotherapeutic targets, which are known bottlenecks in the application of immunotherapy. Herein, we gave an insightful overview of the types of immunotherapy techniques used currently, their mechanisms of action, and discussed some bioinformatics tools and databases applied in the immunotherapy of cancer. This review also provides some future perspectives in the use of bioinformatics tools for immunotherapy.

scholarly journals Past, Present and Future Perspectives on Groundnut Breeding in Burkina Faso

Agronomy ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 704
Author(s):  
Moumouni Konate ◽  
Jacob Sanou ◽  
Amos Miningou ◽  
David Kalule Okello ◽  
Haile Desmae ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Development Research ◽  
Future Perspectives ◽  
Major Drawback ◽  
Essential Information ◽  
Biotic Stresses ◽  
The Past ◽  
Political Independence ◽  
Arachis Hypogaea L ◽  
Yield Penalty

Groundnut (Arachis hypogaea L.) is a major food and cash crop in Burkina Faso. Due to the growing demand for raw oilseeds, there is an increasing interest in groundnut production from traditional rain-fed areas to irrigated environments. However, despite implementation of many initiatives in the past to increase groundnut productivity and production, the groundnut industry still struggles to prosper due to the fact of several constraints including minimal development research and fluctuating markets. Yield penalty due to the presence of drought and biotic stresses continue to be a major drawback for groundnut production. This review traces progress in the groundnut breeding that started in Burkina Faso before the country’s political independence in 1960 through to present times. Up to the 1980s, groundnut improvement was led by international research institutions such as IRHO (Institute of Oils and Oleaginous Research) and ICRISAT (International Crops Research Institute for the Semi-Arid Tropics). However, international breeding initiatives were not sufficient to establish a robust domestic groundnut breeding programme. This review also provides essential information about opportunities and challenges for groundnut research in Burkina Faso, emphasising the need for institutional attention to genetic improvement of the crop.

scholarly journals Interfacing cells with organic transistors: a review of in vitro and in vivo applications

Lab on a Chip ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 795-820
Author(s):  
Andrea Spanu ◽  
Laura Martines ◽  
Annalisa Bonfiglio
Keyword(s):  
Organic Transistors ◽  
Future Perspectives ◽  
The Past ◽  
The Future

This review focuses on the applications of organic transistors in cellular interfacing. It offers a comprehensive retrospective of the past, an overview of the latest innovations, and a glance on the future perspectives of this fast-evolving field.

scholarly journals Modelling and forecasting stock–recruitment: current and future perspectives

2014 ◽  
Vol 71 (8) ◽  
pp. 2307-2322 ◽  
Author(s):  
Sam Subbey ◽  
Jennifer A. Devine ◽  
Ute Schaarschmidt ◽  
Richard D.M. Nash
Keyword(s):  
Present State ◽  
Future Perspectives ◽  
Environmental Covariates ◽  
Explanatory Variables ◽  
Fisheries Science ◽  
The Past ◽  
Methodological Challenges ◽  
Stock Recruitment ◽  
Modelling And Forecasting

AbstractThis paper presents a brief review of the present state of knowledge in stock–recruitment forecasting, including process and current methodological challenges to predicting stock–recruitment. The discussion covers the apparent inability of models to accurately forecast recruitment even when environmental covariates are included as explanatory variables. The review shows that despite the incremental success in the past hundred years, substantial challenges remain if the process of modelling and forecasting stock–recruitment is to become relevant to fisheries science and management in the next 100 years.

Future Perspectives in Drug Development

2005 ◽  
pp. 479-484
Author(s):  
Mei-Ling Chen ◽  
Benjamin Lee ◽  
Christopher Wu
Keyword(s):  
Drug Development ◽  
Future Perspectives

scholarly journals The trends of uveal melanoma research in the past two decades and future perspectives.

2021 ◽  
Author(s):  
Khaled Ali Elubous ◽  
Ali Daoud Alebous ◽  
Hebah Ali Abous ◽  
Rawan Ali Elubous
Keyword(s):  
Uveal Melanoma ◽  
Web Of Science ◽  
The United States ◽  
Future Research ◽  
Genetic Mutations ◽  
Future Perspectives ◽  
Molecular Alterations ◽  
The Past ◽  
Clinical Biomarkers

Abstract PURPOSE Evaluation of the research trends in uveal melanoma in the past two decades.METHODS Data were extracted from the Web of Science database website. VOSviewer and Citespace software were used to analyze the retrieved data. RESULTS The leading country in terms of output and international collaboration is the United States. Research interest in genetic mutations, molecular pathways, and immunotherapy was remarkable in recent years. Most of the top ten journals are specialized in ophthalmology. In recent years the hotspots include future perspectives, BAB1 mutation, therapeutic target, and systematic reviews. The keywords with the strongest citation bursts are immunotherapy, outcome, and in situ hybridization. CONCLUSION The output of uveal melanoma research increased during the past two decades. Future research foci may include exploring different mutations role, immunotherapy, molecular alterations, and finding ideal clinical biomarkers.

scholarly journals Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6039
Author(s):  
Bo Xu ◽  
Hao Wang ◽  
Li Tan
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Embryonic Development ◽  
Cellular Differentiation ◽  
Epigenetic Modification ◽  
Current Understanding ◽  
Future Perspectives ◽  
Cancer Hallmarks ◽  
The Past

DNA methylation (5-methylcytosine, 5mC) was once viewed as a stable epigenetic modification until Rao and colleagues identified Ten-eleven translocation 1 (TET1) as the first 5mC dioxygenase in 2009. TET family genes (including TET1, TET2, and TET3) encode proteins that can catalyze 5mC oxidation and consequently modulate DNA methylation, not only regulating embryonic development and cellular differentiation, but also playing critical roles in various physiological and pathophysiological processes. Soon after the discovery of TET family 5mC dioxygenases, aberrant 5mC oxidation and dysregulation of TET family genes have been reported in breast cancer as well as other malignancies. The impacts of aberrant 5mC oxidation and dysregulated TET family genes on the different aspects (so-called cancer hallmarks) of breast cancer have also been extensively investigated in the past decade. In this review, we summarize current understanding of the causes and consequences of aberrant 5mC oxidation in the pathogenesis of breast cancer. The challenges and future perspectives of this field are also discussed.

scholarly journals Past, Present and Future Perspectives on Groundnut Breeding in Burkina Faso

2019 ◽  
Author(s):  
Moumouni Konate ◽  
Jacob Sanou ◽  
Amos Miningou ◽  
David Kalule Okello ◽  
Haile Desmae ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Development Research ◽  
Future Perspectives ◽  
Major Drawback ◽  
Essential Information ◽  
Biotic Stresses ◽  
The Past ◽  
Political Independence ◽  
Arachis Hypogaea L ◽  
Yield Penalty

Groundnut (Arachis hypogaea L.) is a major food and cash crop in Burkina Faso. Due to growing demand for raw oilseeds, there is an increasing interest in groundnut production from traditional rain-fed areas to irrigated environments. However, despite implementation of many initiatives in the past to increase groundnut productivity and production, the groundnut industry still struggles to prosper, due to several constraints including minimal development research and fluctuating markets. Yield penalty due to drought and biotic stresses continue to be a major drawback for groundnut production. This review traces progress in the groundnut breeding that started in Burkina Faso before the country’s political independence in 1960 through to present times. Up to the 1980s, groundnut improvement was led by international research institutions such as IRHO (Institute of Oils and Oleaginous Research) and ICRISAT (International Crops Research Institute for the Semi-Arid Tropics). However, international breeding initiatives were not sufficient to establish a robust domestic groundnut breeding programme. This review also provides essential information about opportunities and challenges of groundnut research in Burkina Faso, emphasising the need for institutional attention to genetic improvement of the crop.

scholarly journals Cognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Gao ◽  
Xue Shen ◽  
Randy Ko ◽  
Cong Huang ◽  
Changbing Shen
Keyword(s):  
Drug Development ◽  
Skin Disease ◽  
Cognitive Process ◽  
Normal Population ◽  
Genetic Associations ◽  
Inflammatory Skin Disease ◽  
Novel Therapy ◽  
The Past ◽  
Genetic Components ◽  
The World

Psoriasis (PsO) is a chronic inflammatory skin disease that affects approximately 2% of the population all over the world. Comorbidities of PsO have increasingly garnered more interest in the past decades. Compared with the normal population, the incidences of comorbidities are higher among patients with PsO. In the last 20 years, researchers have focused on studying the genetic components of PsO, and genetic associations between PsO and its comorbidities were elucidated. This review provides an in-depth understanding and summarization of the connection between PsO and its comorbidities from the perspectives of epidemiology and genetics. Further understanding of PsO and its comorbidities will promote research on the pathogenesis, drug development, novel therapy methods, and personalized and precision treatment of PsO and its comorbidities.

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