Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age

1992 ◽  
Vol 51 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Yves Lamberty ◽  
Alma J. Gower
Keyword(s):  
Old Age ◽  
Nmri Mice ◽  
Age Related ◽  
Spontaneous Behavior ◽  
Age Related Changes

Age-related changes in natural killer cell receptors from childhood through old age

2011 ◽  
Vol 72 (4) ◽  
pp. 319-329 ◽  
Author(s):  
Aline Almeida-Oliveira ◽  
Monique Smith-Carvalho ◽  
Luis Cristovão Porto ◽  
Juliana Cardoso-Oliveira ◽  
Aline dos Santos Ribeiro ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Old Age ◽  
Killer Cell ◽  
Cell Receptors ◽  
Natural Killer Cell Receptors ◽  
Age Related ◽  
Age Related Changes

scholarly journals International relevance of Two Measures of Awareness of Age-Related Change (AARC)

2020 ◽  
Author(s):  
serena sabatini ◽  
Obioha C Ukoumunne ◽  
Clive Ballard ◽  
Allyson Brothers ◽  
Roman Kaspar ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Old Age ◽  
Factor Structure ◽  
Convergent Validity ◽  
University Education ◽  
Cognitive Health ◽  
Age Related ◽  
Gains And Losses ◽  
Functioning Subscale ◽  
Age Related Changes

Abstract Background: A questionnaire assessing awareness of positive and negative age-related changes (AARC gains and losses) was developed in the US and Germany. We validated the short form of the measure (AARC-10 SF) and the cognitive functioning subscale from the 50-item version of the AARC (AARC-50) questionnaire in the UK population aged 50 and over. Methods: Data from 9,410 participants (Mean (SD) age= 65.9 (7.1)) in the PROTECT cohort were used to explore and confirm the psychometric properties of the AARC measures including: validity of the factor structure; reliability; measurement invariance across men and women, individuals with and without a university degree, and in middle age, early old age, and advanced old age; and convergent validity with measures of self-perception of aging and mental, physical, and cognitive health. We explored the relationship between demographic variables (age, sex, marital status, employment, and university education) and AARC. Results: We confirmed the two-factor structure (gains and losses) of the AARC-10 SF and the AARC-50 cognitive functioning subscale. Both scales showed good reliability and good convergent validity for AARC losses, but weak convergent validity for AARC gains. For both scales metric invariance was held for the two subgroups defined by education level and age. For the AARC-50 subscale, but not for the AARC-10 SF, strong invariance was also held for the two subgroups defined by sex. Age, sex, marital status, employment, and university education predicted AARC gains and losses. Conclusions: The AARC-10 SF and AARC-50 cognitive functioning subscale identify UK individuals who perceive age-related changes in their mental, physical, and cognitive health.

scholarly journals Stability and change in well-being among middle-aged and older Japanese

2020 ◽  
Vol 45 (1) ◽  
pp. 78-88
Author(s):  
Takeshi Nakagawa ◽  
Yukiko Nishita ◽  
Chikako Tange ◽  
Makiko Tomida ◽  
Kaori Kinoshita ◽  
...  
Keyword(s):  
Life Satisfaction ◽  
Negative Affect ◽  
Positive Affect ◽  
Old Age ◽  
Middle Age ◽  
Late Life ◽  
Well Being ◽  
Middle Aged ◽  
Age Related ◽  
Age Related Changes

Prior evidence suggests that subjective well-being (SWB) remains relatively stable across adulthood. However, longitudinal evidence is sparse except in Western societies such as North America and Western Europe. We examined age-related changes in SWB (life satisfaction, positive affect, and negative affect) among middle-aged and older Japanese. We applied multilevel growth models to 14-year seven-wave longitudinal data of a dynamic cohort study. A total of 3,890 participants aged 40–81 at first assessment were included in the analysis. The longitudinal results demonstrated differential trajectories of SWB. Life satisfaction exhibited an accelerated increase in middle age but decreased and leveled off in old age. Positive affect increased in midlife and declined in late life. Negative affect remained stable in middle age but increased in old age. Demographics, health, and methodological correlates did not fully account for age-related changes in SWB. Of note, increases in negative affect in old age remained evident even after controlling for the correlates. In conclusion, life satisfaction was stable across adulthood, which was not the case with positive and negative affect. We discussed the possible mechanisms in these observed trajectories of SWB, in particular, negative affect in late life.

Preparation for old age in different life domains

2013 ◽  
Vol 38 (3) ◽  
pp. 228-238 ◽  
Author(s):  
Anna E. Kornadt ◽  
Klaus Rothermund
Keyword(s):  
Life Span ◽  
Old Age ◽  
Life Domains ◽  
Personality Profiles ◽  
Large Sample ◽  
Domain Specific ◽  
Age Related ◽  
Financial Arrangements ◽  
Age Related Changes

We investigated preparation for age-related changes from a multidimensional, life span perspective and administered a newly developed questionnaire to a large sample aged 30–80 years. Preparing for age-related changes was organized by life domains, with domain-specific types of preparation addressing obstacles and opportunities in the respective domains. Preparing for a third (focusing on activities, leisure, work, fitness, appearance) and a fourth age (focusing on emergencies, dependence/independence, housing, financial arrangements) emerged as superordinate categories of preparation. Different age gradients were obtained for the factors, the former peaking around the age of 65, whereas the latter increased linearly up to the age of 80. Furthermore, preparation factors were characterized by distinct personality profiles. The findings attest to the importance of a differentiated view on preparation for age-related changes and its relevance across the life span.

scholarly journals The Age and Well-Being Paradox Revisited: A Multidimensional Perspective

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 459-459
Author(s):  
Thomas Hansen
Keyword(s):  
Old Age ◽  
Emotional Regulation ◽  
Fixed Effects ◽  
General Pattern ◽  
Well Being ◽  
Older Age ◽  
Men And Women ◽  
Age Related ◽  
Young Old ◽  
Age Related Changes

Abstract Much gerontological research has focused on the paradoxical observation that older people, despite their lower objective quality of life, report higher well-being than younger people. High well-being in old age is believed to be caused by adaptation, emotional regulation, and accommodative strategies. We aim to add nuance by examining whether the “paradox” holds across dimensions of well-being; for men and women; in young old and old-old age; and before introducing statistical controls (e.g for health and social factors). Using fixed effects models and 15-years panel data from the Norwegian NorLAG study (n=2,700, age 40+), we explore age-related changes in cognitive, affective, and eudaimonic dimensions of wellbeing. Results indicate a general pattern of stability well into older age, but negative changes in advanced age, cross-sectionally and longitudinally, and for each well-being measure. Declines in well-being are less pronounced and with a later onset for the cognitive compared with the other measures. Results are similar for men and women. Loss of health and partner are the main causes of declining well-being in older age. Findings suggest qualifications to the “well-being paradox”, e.g.: some dimensions of well-being remain more stable than others; across dimensions of well-being change is more negative in old-old than in young-old age; and patterns of increasing well-being in older age are more pronounced after controlling for age-related changes in health and social roles. We argue that the use of controls makes for false impressions of the psychological changes that actually occur when people grow older.

scholarly journals The Impact of Milk Fat Globule Membrane with Exercise on Age-Related Degeneration of Neuromuscular Junctions

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2310
Author(s):  
Satoshi Sugita ◽  
Kotaro Tamura ◽  
Michiko Yano ◽  
Yoshihiko Minegishi ◽  
Noriyasu Ota
Keyword(s):  
Old Age ◽  
Milk Fat ◽  
Neuromuscular Junctions ◽  
Motor Dysfunction ◽  
Milk Fat Globule Membrane ◽  
Age Related ◽  
Milk Fat Globule ◽  
Fat Globule ◽  
The Impact ◽  
Age Related Changes

Morphological changes in neuromuscular junctions (NMJs), which are synapses formed between α-motor neurons and skeletal muscle fibers, are considered to be important in age-related motor dysfunction. We have previously shown that the intake of dietary milk fat globule membrane (MFGM) combined with exercise attenuates age-related NMJ alterations in the early phase of aging. However, it is unclear whether the effect of MFGM with exercise on age-related NMJ alterations persists into old age, and whether intervention from old age is still effective when age-related changes in NMJs have already occurred. In this study, 6- or 18-month-old mice were treated with a 1% MFGM diet and daily running wheel exercise until 23 or 24 months of age, respectively. MFGM treatment with exercise was effective in suppressing the progression of age-related NMJ alterations in old age, and even after age-related changes in NMJs had already occurred. Moreover, the effect of MFGM intake with exercise was not restricted to NMJs but extended to the structure and function of peripheral nerves. This study demonstrates that MFGM intake with exercise may be a novel approach for improving motor function in the elderly by suppressing age-related NMJ alterations.

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