Age-related changes in B and T lymphocytes and decline of humoral immune responsiveness in aged mice

1977 ◽  
Vol 6 ◽  
pp. 115-129 ◽  
Author(s):  
Diego Segre ◽  
Mariangela Segre
Keyword(s):  
T Lymphocytes ◽  
Immune Responsiveness ◽  
Aged Mice ◽  
Humoral Immune ◽  
Age Related ◽  
Humoral Immune Responsiveness ◽  
B And T Lymphocytes ◽  
Age Related Changes

scholarly journals Rituximab treatment results in impaired secondary humoral immune responsiveness

Blood ◽  
2002 ◽  
Vol 100 (6) ◽  
pp. 2257-2259 ◽  
Author(s):  
Lizet E. van der Kolk ◽  
Joke W. Baars ◽  
Martin H. Prins ◽  
Marinus H. J. van Oers
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Infectious Complications ◽  
Low Grade ◽  
Immune Responsiveness ◽  
B Cell Depletion ◽  
Treatment Results ◽  
Humoral Immune ◽  
Immunoglobulin Levels ◽  
Humoral Immune Responsiveness

Abstract In lymphoma patients, treatment with chimeric CD20 monoclonal antibodies (rituximab) results in a depletion of normal and malignant B cells, persisting for 6 to 9 months. This B-cell depletion leads neither to a decrease in immunoglobulin levels nor an increase in the number of infectious complications. However, the effect of rituximab treatment on the immune responsiveness is unknown. In 11 patients with relapsed, low-grade lymphoma, we investigated the effect of rituximab treatment on the humoral immune response to 2 primary antigens and 2 recall antigens. After rituximab treatment, the humoral immune response to the recall antigens was significantly decreased when compared with the response before treatment. Already before rituximab treatment, none of these patients was able to mount a response to the primary antigens. These findings are relevant regarding the feasibility of rituximab in maintenance treatment and may also offer a rationale for the treatment of antibody-mediated autoimmune diseases with rituximab.

scholarly journals Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
S. S. Jeske ◽  
P. J. Schuler ◽  
J. Doescher ◽  
M. N. Theodoraki ◽  
S. Laban ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Age Related ◽  
Age Related Changes

scholarly journals Antibody-specific immunoregulation and the immunodeficiency of aging.

1981 ◽  
Vol 154 (2) ◽  
pp. 547-551 ◽  
Author(s):  
N R Klinman
Keyword(s):  
B Cells ◽  
Heavy Chain ◽  
Antibody Repertoire ◽  
Causative Role ◽  
Immune Responsiveness ◽  
Spleen Cells ◽  
Humoral Immune ◽  
Humoral Immune Responsiveness ◽  
Young Mice

Experiments were carried out to assess the role of naturally acquired antibody-specific immunoregulation in the immunodeficiency of aged individuals. It was found that greater than 50% of the primary dinitrophenyl-specific BALB/c B cells did not respond in carrier-primed 2-yr-old BALB/c adoptive hosts as compared with similarly primed younger recipients. Similar suppression was observed in carrier-primed younger BALB/c mice that had received 4 x 10(7) spleen cells from 2-yr-old BALB/c mice, as opposed to those that had received 4 x 10(7) spleen cells from younger mice. This diminution in responsiveness was noted only for syngeneic BALB/c B cells because B cells of strains differing from BALB/c in the heavy chain allotype-idiotype locus were not suppressed. These findings indicate that old, but not young, mice had developed the capacity to suppress primary B cells bearing receptors expressing much of the syngeneic antibody repertoire. This suppression may play an important causative role in the relatively poor humoral immune responsiveness of aged individuals.

scholarly journals Humoral immune responsiveness in duck hepatitis B virus-infected ducks.

1987 ◽  
Vol 61 (3) ◽  
pp. 916-920 ◽  
Author(s):  
M S Halpern ◽  
W S Mason ◽  
L Coates ◽  
A P O'Connell ◽  
J M England
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responsiveness ◽  
Duck Hepatitis B Virus ◽  
Humoral Immune ◽  
Duck Hepatitis ◽  
B Virus ◽  
Humoral Immune Responsiveness

scholarly journals Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Marija Holcar ◽  
Aleš Goropevšek ◽  
Alojz Ihan ◽  
Tadej Avčin
Keyword(s):  
Flow Cytometry ◽  
T Lymphocytes ◽  
Lymphocyte Subsets ◽  
Healthy Individuals ◽  
Helper T Lymphocytes ◽  
Age Related ◽  
Healthy Donors ◽  
Adolescents And Adults ◽  
Age Related Changes ◽  
Th Lymphocytes

The dynamic process of the development of the immune system can in itself result in age-related immune malfunctions. In this study, we analysed lymphocyte subsets in the peripheral blood of 60 healthy donors, divided into groups of children, adolescents, and adults, focusing on effector (Teff) and regulatory (Treg) T lymphocytes and STAT1/STAT5 signalling response in helper T lymphocytes (Th) in adults, using flow cytometry. Our results demonstrate a decrease in the percentage of total Tregs and an increase in the percentage of total Teffs with age and a consequential immense increase in the Teff/Treg ratio. The increase of Teffs was most apparent in Th1, Th1Th17, and Th17CD161− subsets. Significant Th lymphocyte STAT1 expression differences were observed between children and adolescents, which were associated with the decrease in activated Tregs. Higher expression of STAT1 was found in FoxP3hi than in FoxP3low Th lymphocytes, while significant IL-2 induced STAT5 phosphorylation differences were found among the subsets of Th lymphocytes in adults. Our study demonstrates age-related changes in circulating Teff and Treg, as well as significant differences in STAT5/STAT1 signalling among FoxP3+ Th lymphocytes, providing new advances in the understanding of immunosenescence.

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