Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammatory response on titanium implants

Biomaterials ◽  
1989 ◽  
Vol 10 (3) ◽  
pp. 166-175 ◽  
Author(s):  
Pentti Tengvall ◽  
Ingemar Lundström ◽  
Lars Sjöqvist ◽  
Hans Elwing ◽  
Lars Magnus Bjursten
Keyword(s):  
Hydrogen Peroxide ◽  
Inflammatory Response ◽  
Interaction Model ◽  
Titanium Implants ◽  
Model Studies

In Situ Characterization of Surface Evolution on Titanium in Hydrogen Peroxide Containing Solutions

2005 ◽  
Vol 873 ◽  
Author(s):  
Julie J. Muyco ◽  
Jeremy J. Gray ◽  
Timothy V. Ratto ◽  
Christine A. Orme ◽  
Joanna McKittrick ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Raman Spectroscopy ◽  
Inflammatory Response ◽  
Electrochemical Techniques ◽  
Chemical Species ◽  
Sample Surface ◽  
Titanium Implants ◽  
The Body ◽  
Surface Evolution

AbstractTitanium implants have been used for decades with success in various applications. The characteristics of titanium that allows acceptance in the body are not well defined. It is known that hydrogen peroxide is a chemical species produced during the inflammatory response following implantation. When titanium is exposed to hydrogen peroxide, a Ti-peroxy gel (TiOOH) is formed. Three possible functions of Ti-peroxy gel are: reduction of the inflammatory response through the reduction of hydrogen peroxide and other reactive oxygen species; creation of a favorable surface for calcium phosphate nucleation; and as a transitional layer between the soft tissue and the stiff titanium. These studies utilized atomic force microscopy (AFM) force spectroscopy, electrochemical techniques, Raman spectroscopy, and optical transparency in situ to define kinetic and mechanical properties of Ti-peroxy gel as it forms on titanium during exposure to hydrogen peroxide. Peaks attributed to Ti-peroxy gel were seen to emerge over the course of several hours using in situ Raman spectroscopy. Force-distance curves suggest a layer that thickens with time on the titanium sample surface.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

scholarly journals Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

2013 ◽  
Vol 23 (5) ◽  
pp. 424-429 ◽  
Author(s):  
William Razzell ◽  
Iwan Robert Evans ◽  
Paul Martin ◽  
Will Wood
Keyword(s):  
Hydrogen Peroxide ◽  
Inflammatory Response ◽  
Hydrogen Peroxide Release

scholarly journals Biocompatibility of acellular dermal matrix graft evaluated in culture of murine macrophages

2006 ◽  
Vol 14 (2) ◽  
pp. 67-70 ◽  
Author(s):  
Ana Paula Vendramini ◽  
Rafaela Fernanda Melo ◽  
Rosemary Adriana Chiérici Marcantonio ◽  
Iracilda Zepone Carlos
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Statistical Analysis ◽  
Inflammatory Response ◽  
Acellular Dermal Matrix ◽  
Negative Control ◽  
Dermal Matrix ◽  
Murine Macrophages ◽  
Significant Difference ◽  
Acellular Dermal

The acellular dermal matrix allograft has been used as an alternative to autogenous palatal mucosal graft. The aim of this study was the evaluation of the biocompatibility of an acellular dermal matrix (AlloDerm®) in culture of macrophages. For hydrogen peroxidase determination we used the method of Pick & Kesari, and the Griess method for nitric oxide determination,. Statistical analysis showed no significant difference (p < 0,05) in the release of nitric oxide and hydrogen peroxide by the macrophages exposed to acellular dermal matrix and the negative control. The results suggest that acellular dermal matrix did not activate the cell inflammatory response.

In vivo investigation of the inflammatory response against allylamine plasma polymer coated titanium implants in a rat model

2010 ◽  
Vol 6 (2) ◽  
pp. 676-683 ◽  
Author(s):  
A. Hoene ◽  
U. Walschus ◽  
M. Patrzyk ◽  
B. Finke ◽  
S. Lucke ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Rat Model ◽  
Titanium Implants ◽  
Plasma Polymer

Growth Inhibition by Glucose Oxidase of Selected Organisms Associated With the Microbial Spoilage of Shrimp (Pandalus jordani): In Vitro Model Studies

1993 ◽  
Vol 56 (2) ◽  
pp. 147-152 ◽  
Author(s):  
C. A. KANTT ◽  
J. A. TORRES
Keyword(s):  
Hydrogen Peroxide ◽  
Growth Inhibition ◽  
Glucose Oxidase ◽  
Gluconic Acid ◽  
Hansenula Polymorpha ◽  
Model Studies ◽  
Vitro Model ◽  
Effect Of Glucose ◽  
Enzyme Ratio

The effect of glucose oxidase (GOX)-catalase with different GOX-catalase ratios and of the Chemicals produced by GOX, gluconic acid and hydrogen peroxide, were evaluated on four microorganisms usually present in shrimp. Growth inhibition was independent of the enzyme ratio within the limits tested. Hydrogen peroxide inhibited Pseudomonas fluorescens, Hansenula polymorpha and Acinetobacter calcoaceticum. Only Corynebacter aquaticum was inhibited by gluconic acid but was not affected by hydrogen peroxide.

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