Basal cell carcinoma in Kauai, Hawaii: The highest documented incidence in the United States

1993 ◽  
Vol 29 (2) ◽  
pp. 184-189 ◽  
Author(s):  
George T. Reizner ◽  
Tsu-Yi Chuang ◽  
David J. Elpern ◽  
Jenny L. Stone ◽  
Evan R. Farmer
2021 ◽  
pp. 1-2
Author(s):  
Aravind Reddy Kuchkuntla ◽  

Basal cell carcinoma (BCC) is the most common cancer worldwide with an estimated annual incidence of 2 million in the United States. Majority of the patients present with a suspicious skin lesion with surrounding soft tissue destruction, but distant metastasis is rare, reportedly in less than 0.05-0.1% of all cases. So far, around 350 cases have been reported with majority of metastases occurring in primary lesions of head and neck. Here, we present a patient with high-risk BCC lesion presenting with distant metastasis.


2011 ◽  
Vol 130 (12) ◽  
pp. 2939-2948 ◽  
Author(s):  
Elizabeth K. Cahoon ◽  
Preetha Rajaraman ◽  
Bruce H. Alexander ◽  
Michele M. Doody ◽  
Martha S. Linet ◽  
...  

Author(s):  
Audris Chiang ◽  
Daniel C. Solis ◽  
Howard Rogers ◽  
Grace K. Sohn ◽  
Hyunje G. Cho ◽  
...  

2014 ◽  
Vol 32 (30_suppl) ◽  
pp. 17-17
Author(s):  
Xinyuan Wu ◽  
Elena B. Elkin ◽  
Jason Chih-Shan Chen ◽  
Ashfaq A. Marghoob

17 Background: Basal cell carcinoma (BCC) is the most common cancer in the US, affecting more than 3 million people every year, and the incidence of BCC is increasing. Traditional management of BCC involves multiple physician visits and a pre-treatment biopsy which may be unnecessary. We assessed the costs of treating BCC, comparing traditional management with a simplified scheme. Methods: We developed a decision analytic model to compare the costs of traditional BCC management with a simplified Detect and Treat (DAT) scheme that eliminates pre-treatment biopsy. We assumed that all patients had an unequivocal BCC diagnosis based on clinical and dermoscopic findings. In the traditional approach, all patients had a biopsy prior to treatment. In the DAT scheme, well delineated lesions ≤1cm in diameter on the trunk and extremities were treated with shave removal and Mohs indicated lesions were referred to Mohs for on-site histologic check, both eliminating pre-treatment biopsy. Distributions of lesion location, size and treatment modality, and estimates of clinical diagnostic accuracy and success of shave removal were from the literature and from an analysis of 240 consecutive BCC cases seen over 5 years at our institution. Costs were based on assumptions about the number of dermatologist visits, tests and procedures required for each strategy, and unit prices from the 2014 Medicare physician fee schedule. Results: The average cost per case in the DAT scheme was $449 for non-Mohs-indicated lesions and $819 for Mohs-indicated lesions, compared with $566 and $864, respectively, with traditional management. DAT was associated with a savings of $117 (21% of total average cost) per non-Mohs-indicated case and $45 (5% of total average cost) per Mohs-indicated case. The combined weighted average savings per case was $95 (15% of total average cost). The magnitude of savings varied with changes in model parameters, but conclusions were similar under a wide range of plausible scenarios. Conclusions: A simplified management strategy that avoids routine pre-treatment biopsy can reduce the cost of treating BCC without compromising quality of care.


2015 ◽  
Vol 148 ◽  
pp. 284-289 ◽  
Author(s):  
D. Michal Freedman ◽  
Cari M. Kitahara ◽  
Martha S. Linet ◽  
Bruce H. Alexander ◽  
Gila Neta ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3870
Author(s):  
James M. Kilgour ◽  
Justin L. Jia ◽  
Kavita Y. Sarin

Basal cell carcinoma (BCC) is a significant public health concern, with more than 3 million cases occurring each year in the United States, and with an increasing incidence. The molecular basis of BCC is complex, involving an interplay of inherited genetic susceptibility, including single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, often induced by carcinogenic exposure to UV radiation. This review outlines the currently known germline and somatic mutations implicated in the pathogenesis of BCC, including the key molecular pathways affected by these mutations, which drive oncogenesis. With advances in next generation sequencing and our understanding of the molecular genetics of BCC, established and emerging targeted therapeutics are offering new avenues for the non-surgical treatment of BCC. These agents, including Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, will also be discussed.


2015 ◽  
Vol 18 (3) ◽  
pp. A193-A194
Author(s):  
G. Goldenberg ◽  
T.S. Karagiannis ◽  
J.B. Palmer ◽  
J. Lotya ◽  
C.B. O’Neill ◽  
...  

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