From biological membrane processes to industrial membrane technologies

1987 ◽  
Vol 17 (1) ◽  
pp. 121-129
Author(s):  
R. Buvet
Keyword(s):  
Biological Membrane ◽  
Membrane Processes ◽  
Membrane Technologies

Membrane-Based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-Coated Crystals/Particles

2017 ◽  
Vol 23 (2) ◽  
pp. 242-249 ◽  
Author(s):  
Dengyue Chen ◽  
Kamalesh K. Sirkar ◽  
Chi Jin ◽  
Dhananjay Singh ◽  
Robert Pfeffer
Keyword(s):  
Organic Solvent ◽  
Hollow Fiber ◽  
Membrane Filtration ◽  
Continuous Production ◽  
Pharmaceutical Compounds ◽  
Biopharmaceutical Industry ◽  
Separation And Purification ◽  
Membrane Processes ◽  
Gaseous Mixtures ◽  
Membrane Technologies

Background: Membrane technologies are of increasing importance in a variety of separation and purification applications involving liquid phases and gaseous mixtures. Although the most widely used applications at this time are in water treatment including desalination, there are many applications in chemical, food, healthcare, paper and petrochemical industries. This brief review is concerned with existing and emerging applications of various membrane technologies in the pharmaceutical and biopharmaceutical industry. Methods: The goal of this review article is to identify important membrane processes and techniques which are being used or proposed to be used in the pharmaceutical and biopharmaceutical operations. How novel membrane processes can be useful for delivery of crystalline/particulate drugs is also of interest. Results: Membrane separation technologies are extensively used in downstream processes for bio-pharmaceutical separation and purification operations via microfiltration, ultrafiltration and diafiltration. Also the new technique of membrane chromatography allows efficient purification of monoclonal antibodies. Membrane filtration techniques of reverse osmosis and nanofiltration are being combined with bioreactors and advanced oxidation processes to treat wastewaters from pharmaceutical plants. Nanofiltration with organic solvent-stable membranes can implement solvent exchange and catalyst recovery during organic solvent-based drug synthesis of pharmaceutical compounds/intermediates. Membranes in the form of hollow fibers can be conveniently used to implement crystallization of pharmaceutical compounds. The novel crystallization methods of solid hollow fiber cooling crystallizer (SHFCC) and porous hollow fiber anti-solvent crystallization (PHFAC) are being developed to provide efficient methods for continuous production of polymer-coated drug crystals in the area of drug delivery. Conclusion: This brief review provides a general introduction to various applications of membrane technologies in the pharmaceutical/biopharmaceutical industry with special emphasis on novel membrane techniques for pharmaceutical applications. The method of coating a drug particle with a polymer using the SHFCC method is stable and ready for scale-up for operation over an extended period.

Membrane Processes in Water and Wastewater Treatment

2020 ◽  
pp. 109-136
Keyword(s):  
Lower Energy ◽  
Energy Requirement ◽  
Membrane Bioreactors ◽  
Water And Wastewater Treatment ◽  
Membrane Processes ◽  
Critical Flux ◽  
Liquid Phases ◽  
Water And Wastewater ◽  
Contaminants Removal ◽  
Membrane Technologies

Membrane technologies play a very important role in water and wastewater treatments. These membrane processes provide key advantages over the conventional processes, such as lower energy requirement, lower footprint, easier to operate, and more effective contaminants removal. This chapter introduces different membrane processes: (1) pressure-driven membrane processes which are the most widely used in water and wastewater treatments, and (2) several advanced membrane processes. These processes perform physical or physicochemical separations. Most of the separations occur between liquid-liquid phases, but liquid-gas and gas-gas separation phases are also performed in the latest membrane development. The contemporary membrane bioreactor is the heart of membrane technologies that are used in various applications. However, fouling is a common phenomenon that reduces the efficiency of the membrane operation. Thus, the concept of critical flux and introduction of some control and preventive mechanism could prevent or reduce the fouling in membrane bioreactors.

scholarly journals Use of Membrane Technologies in Dairy Industry: An Overview

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2768
Author(s):  
Mònica Reig ◽  
Xanel Vecino ◽  
José Luis Cortina
Keyword(s):  
Capital Expenditure ◽  
Dairy Industry ◽  
Value Added ◽  
Water Source ◽  
Added Value ◽  
Yield Enhancement ◽  
Membrane Processes ◽  
Membrane Technologies ◽  
Industrial Solutions ◽  
Traditional Processing

The use of treatments of segregated process streams as a water source, as well as technical fluid reuse as a source of value-added recovery products, is an emerging direction of resource recovery in several applications. Apart from the desired final product obtained in agro-food industries, one of the challenges is the recovery or separation of intermediate and/or secondary metabolites with high-added-value compounds (e.g., whey protein). In this way, processes based on membranes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO), could be integrated to treat these agro-industrial streams, such as milk and cheese whey. Therefore, the industrial application of membrane technologies in some processing stages could be a solution, replacing traditional processes or adding them into existing treatments. Therefore, greater efficiency, yield enhancement, energy or capital expenditure reduction or even an increase in sustainability by producing less waste, as well as by-product recovery and valorization opportunities, could be possible, in line with industrial symbiosis and circular economy principles. The maturity of membrane technologies in the dairy industry was analyzed for the possible integration options of membrane processes in their filtration treatment. The reported studies and developments showed a wide window of possible applications for membrane technologies in dairy industry treatments. Therefore, the integration of membrane processes into traditional processing schemes is presented in this work. Overall, it could be highlighted that membrane providers and agro-industries will continue with a gradual implementation of membrane technology integration in the production processes, referring to the progress reported on both the scientific literature and industrial solutions commercialized.

Membrane technologies for sports supplementation

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Maciej Staszak
Keyword(s):  
Healthy Food ◽  
Industrial Processes ◽  
Membrane Processes ◽  
Membrane Technologies

Abstract The important developments in membrane techniques used in the dairy industrial processes to whey manufacturing are discussed. Particular emphasis is placed on the description of membrane processes, characterization of protein products, biological issues related to bacteriophages contamination, and modeling of the processes. This choice was dictated by the observed research works and consumer trends, who increasingly appreciate healthy food and its taste qualities.

Separation of Biologically Active Compounds by Membrane Operations

2017 ◽  
Vol 23 (2) ◽  
pp. 218-230 ◽  
Author(s):  
Xiaoying Zhu ◽  
Renbi Bai
Keyword(s):  
Energy Consumption ◽  
Bioactive Compounds ◽  
Membrane Fouling ◽  
Membrane Separation ◽  
Separation Efficiency ◽  
High Energy ◽  
Separation Processes ◽  
Membrane Processes ◽  
Separation Technology ◽  
Pressure Driven

Background: Bioactive compounds from various natural sources have been attracting more and more attention, owing to their broad diversity of functionalities and availabilities. However, many of the bioactive compounds often exist at an extremely low concentration in a mixture so that massive harvesting is needed to obtain sufficient amounts for their practical usage. Thus, effective fractionation or separation technologies are essential for the screening and production of the bioactive compound products. The applicatons of conventional processes such as extraction, distillation and lyophilisation, etc. may be tedious, have high energy consumption or cause denature or degradation of the bioactive compounds. Membrane separation processes operate at ambient temperature, without the need for heating and therefore with less energy consumption. The “cold” separation technology also prevents the possible degradation of the bioactive compounds. The separation process is mainly physical and both fractions (permeate and retentate) of the membrane processes may be recovered. Thus, using membrane separation technology is a promising approach to concentrate and separate bioactive compounds. Methods: A comprehensive survey of membrane operations used for the separation of bioactive compounds is conducted. The available and established membrane separation processes are introduced and reviewed. Results: The most frequently used membrane processes are the pressure driven ones, including microfiltration (MF), ultrafiltration (UF) and nanofiltration (NF). They are applied either individually as a single sieve or in combination as an integrated membrane array to meet the different requirements in the separation of bioactive compounds. Other new membrane processes with multiple functions have also been developed and employed for the separation or fractionation of bioactive compounds. The hybrid electrodialysis (ED)-UF membrane process, for example has been used to provide a solution for the separation of biomolecules with similar molecular weights but different surface electrical properties. In contrast, the affinity membrane technology is shown to have the advantages of increasing the separation efficiency at low operational pressures through selectively adsorbing bioactive compounds during the filtration process. Conclusion: Individual membranes or membrane arrays are effectively used to separate bioactive compounds or achieve multiple fractionation of them with different molecule weights or sizes. Pressure driven membrane processes are highly efficient and widely used. Membrane fouling, especially irreversible organic and biological fouling, is the inevitable problem. Multifunctional membranes and affinity membranes provide the possibility of effectively separating bioactive compounds that are similar in sizes but different in other physical and chemical properties. Surface modification methods are of great potential to increase membrane separation efficiency as well as reduce the problem of membrane fouling. Developing membranes and optimizing the operational parameters specifically for the applications of separation of various bioactive compounds should be taken as an important part of ongoing or future membrane research in this field.

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

2020 ◽  
Vol 20 (3) ◽  
pp. 195-206 ◽  
Author(s):  
Shriya Agarwal ◽  
Vinayak Agarwal ◽  
Mugdha Agarwal ◽  
Manisha Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Immune Responses ◽  
Biological Membrane ◽  
Gene Isolation ◽  
Delivery Vehicle ◽  
Scientific Communities ◽  
Therapeutic Regime ◽  
Targeted Gene Therapy ◽  
Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

Sign in / Sign up

Export Citation Format

Share Document