Lab-on-a-chip sensing devices for biomedical applications

2019 ◽  
pp. 47-95
Author(s):  
Pavel Sengupta ◽  
Kalap Khanra ◽  
Amit Roy Chowdhury ◽  
Pallab Datta
Keyword(s):  
Biomedical Applications ◽  
Lab On A Chip

Lab-on-a-chip synthesis of inorganic nanomaterials and quantum dots for biomedical applications

2013 ◽  
Vol 65 (11-12) ◽  
pp. 1470-1495 ◽  
Author(s):  
Katla Sai Krishna ◽  
Yuehao Li ◽  
Shuning Li ◽  
Challa S.S.R. Kumar
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Lab On A Chip ◽  
Inorganic Nanomaterials

Emerging Phospholipid Nanobiomaterials for Biomedical Applications to Lab-on-a-Chip, Drug Delivery, and Cellular Engineering

2021 ◽  
Author(s):  
Maedeh Rahimnejad ◽  
Navid Rabiee ◽  
Sepideh Ahmadi ◽  
Sepideh Jahangiri ◽  
S. Mohammad Sajadi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Lab On A Chip ◽  
Cellular Engineering

Electroosmotic micropump for lab-on-a-chip biomedical applications

2016 ◽  
Vol 29 (5) ◽  
pp. 845-858 ◽  
Author(s):  
Mohammad Karim Dehghan Manshadi ◽  
Danial Khojasteh ◽  
Mehdi Mohammadi ◽  
Reza Kamali
Keyword(s):  
Biomedical Applications ◽  
Lab On A Chip

scholarly journals Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 916
Author(s):  
Cristina Elena Staicu ◽  
Florin Jipa ◽  
Emanuel Axente ◽  
Mihai Radu ◽  
Beatrice Mihaela Radu ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
High Throughput ◽  
High Throughput Screening ◽  
Biomedical Applications ◽  
Neurovascular Unit ◽  
Lab On A Chip ◽  
Brain Barrier ◽  
Blood Brain ◽  
Pharmacological Screening ◽  
The Brain

Lab-on-a-chip (LOC) and organ-on-a-chip (OOC) devices are highly versatile platforms that enable miniaturization and advanced controlled laboratory functions (i.e., microfluidics, advanced optical or electrical recordings, high-throughput screening). The manufacturing advancements of LOCs/OOCs for biomedical applications and their current limitations are briefly discussed. Multiple studies have exploited the advantages of mimicking organs or tissues on a chip. Among these, we focused our attention on the brain-on-a-chip, blood–brain barrier (BBB)-on-a-chip, and neurovascular unit (NVU)-on-a-chip applications. Mainly, we review the latest developments of brain-on-a-chip, BBB-on-a-chip, and NVU-on-a-chip devices and their use as testing platforms for high-throughput pharmacological screening. In particular, we analyze the most important contributions of these studies in the field of neurodegenerative diseases and their relevance in translational personalized medicine.

scholarly journals Microfluidic-assisted synthesis and modelling of monodispersed magnetic nanocomposites for biomedical applications

2020 ◽  
Vol 9 (1) ◽  
pp. 1397-1407
Author(s):  
Omid Sartipzadeh ◽  
Seyed Morteza Naghib ◽  
Farhad Shokati ◽  
Mehdi Rahmanian ◽  
Keivan Majidzadeh-A ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Lab On A Chip ◽  
Cell Encapsulation ◽  
Cell Isolation ◽  
Two Phase ◽  
Experimental Procedure ◽  
Velocity Flow

Abstract Droplet microfluidic was devoted to design and fabricate robust devices in the field of biosensing, tissue engineering, drug delivery, cell encapsulation, cell isolation, and lab-on-a-chip. Chitosan was widely used for different biomedical applications because of its unique characteristics such as antibacterial bioactivities, immune-enhancing influences, and anticancer bioactivities. In this research, a model is used for investigating the formation and size of composite droplets in a microfluidic device. The role of the velocity flow ratio in the composite droplet characteristics such as the generation rate and composite droplet size is described. According to the results, a desirable protocol is developed to control the properties of the composite droplets and to compare the size and rate of the composite droplets in a micro device. Furthermore, the level set laminar two-phase flow approach is exploited for studying the composite droplet-breaking procedure. An experimental procedure is used for validation of the simulation process. Various sizes and geometries of the composite droplets are fabricated to depict a potential in biomedical applications such as bioimaging, biosensing, tissue engineering, drug delivery, cell encapsulation, cancer cell isolation, and lab-on-a-chip.

scholarly journals Magnetic control of graphitic microparticles in aqueous solutions

2019 ◽  
Vol 116 (7) ◽  
pp. 2425-2434 ◽  
Author(s):  
Johnny Nguyen ◽  
Dario Valter Conca ◽  
Johannes Stein ◽  
Laura Bovo ◽  
Chris A. Howard ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Biomedical Applications ◽  
Condensed Matter ◽  
Lab On A Chip ◽  
Magnetic Control ◽  
Liquid Media ◽  
Magnetic Manipulation ◽  
Positioning Control ◽  
Remote Manipulation ◽  
Magnetic Transport

Graphite is an inexpensive material with useful electrical, magnetic, thermal, and optical properties. It is also biocompatible and used universally as a substrate. Micrometer-sized graphitic particles in solution are therefore ideal candidates for novel lab-on-a-chip and remote manipulation applications in biomedicine, biophysics, chemistry, and condensed-matter physics. However, submerged graphite is not known to be amenable to magnetic manipulation, the optimal manipulation method for such applications. Here, we exploit the diamagnetism of graphite and demonstrate contactless magnetic positioning control of graphitic microflakes in diamagnetic aqueous solutions. We develop a theoretical model for magnetic manipulation of graphite microflakes and demonstrate experimentally magnetic transport of such particles over distances ∼200 μm with peak velocities ∼15 μm/s in inhomogeneous magnetic fields. We achieve fully biocompatible transport for lipid-coated graphite in NaCl aqueous solution, paving the way for previously undiscovered biomedical applications. Our results prove that micrometer-sized graphite can be magnetically manipulated in liquid media.

Simulation of MEMS Piezoelectric Micropump for Biomedical Applications

2002 ◽  
Author(s):  
Walied A. Moussa ◽  
Ulises F. Gonza´lez
Keyword(s):  
Biomedical Applications ◽  
Piezoelectric Effect ◽  
Lab On A Chip ◽  
Mechanical Efficiency ◽  
Driving Frequency ◽  
Element Analysis ◽  
Pump Performance ◽  
Event Simulation ◽  
Simulation Techniques ◽  
Resonance Behavior

In this study, we demonstrate the usefulness of Finite Element Analysis (FEA) and simulation techniques in the design of MEMS micropumps. Such pumps provide for the handling of milliliter-scaled fluid volumes desired in many lab-on-a-chip chemical and biomedical applications. This work is focused on a micropump driven by the piezoelectric effect, which in turn invokes the dominant resonance behavior. Because the design of the device is the emphasis of this study, the model was originated in CAD and includes the fme-scale geometric details commonly encountered in a wide variety of micropumps. The model considered in this study is a rectangular micropump with a piezoelectrically actuated diaphragm on its top and two valves on its bottom. The mechanical efficiency of the pump hinges on using resonance to generate sufficient motion of the diaphragm. Mechanical Event Simulation (MES) commercial software from ALGOR was utilized to simulate this motion, and thus provide a method for optimizing the design. The results show that consideration needs to be given to the voltage-driving frequency because of its effect on the pump performance and the stress levels within it.

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