Additive manufacturing (AM) of medical devices and scaffolds for tissue engineering based on 3D and 4D printing

At present, biomaterials are used in several sectors of medicine such as implant manufacturing, tissue engineering, orthopedic and prosthetic aids, drug delivery systems and many others. The use of biomaterials is increasingly related to the additive manufacturing (AM) of various medical devices and aids. Biomaterials and their use in medicine are important not only in terms of their biocompatibility and direct effect on the human organism, but also in terms of their biodegradability, processability and non-toxicity to the environment either during their production or during their processing after use. Bioplastics of the type Polylactic acid (PLA) appears to be a suitable biomaterials for use in a variety of medical applications in conjunction with an AM process. For this reason, this article discusses 1) description and use of biomaterials in medical applications 2) AM and biomaterials 3) key properties and uses of PLA bioplastics in medicine and 4) the specific AM of an orthopedic corset made of PLA and its benefits.

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Regeneration von Knochendefekten mit computergesteuerter Herstellung von Gerüstträgern

Osteologie/Osteology ◽

10.1055/s-0038-1630122 ◽

2013 ◽

Vol 22 (03) ◽

pp. 180-187 ◽

Cited By ~ 3

Author(s):

J. Henke ◽

J. T. Schantz ◽

D. W. Hutmacher

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

Custom Made

ZusammenfassungDie Behandlung ausgedehnter Knochen-defekte nach Traumata oder durch Tumoren stellt nach wie vor eine signifikante Heraus-forderung im klinischen Alltag dar. Aufgrund der bestehenden Limitationen aktueller Therapiestandards haben Knochen-Tissue-Engineering (TE)-Verfahren zunehmend an Bedeutung gewonnen. Die Entwicklung von Additive-Manufacturing (AM)-Verfahren hat dabei eine grundlegende Innovation ausgelöst: Durch AM lassen sich dreidimensionale Gerüstträger in einem computergestützten Schichtfür-Schicht-Verfahren aus digitalen 3D-Vorlagen erstellen. Wurden mittels AM zunächst nur Modelle zur haptischen Darstellung knöcherner Pathologika und zur Planung von Operationen hergestellt, so ist es mit der Entwicklung nun möglich, detaillierte Scaffoldstrukturen zur Tissue-Engineering-Anwendung im Knochen zu fabrizieren. Die umfassende Kontrolle der internen Scaffoldstruktur und der äußeren Scaffoldmaße erlaubt eine Custom-made-Anwendung mit auf den individuellen Knochendefekt und die entsprechenden (mechanischen etc.) Anforderungen abgestimmten Konstrukten. Ein zukünftiges Feld ist das automatisierte ultrastrukturelle Design von TE-Konstrukten aus Scaffold-Biomaterialien in Kombination mit lebenden Zellen und biologisch aktiven Wachstumsfaktoren zur Nachbildung natürlicher (knöcherner) Organstrukturen.

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Additive Manufacturing in Medicine and Tissue Engineering: Plenary Talk

2021 IEEE 19th World Symposium on Applied Machine Intelligence and Informatics (SAMI) ◽

10.1109/sami50585.2021.9378685 ◽

2021 ◽

Author(s):

Radovan Hudak ◽

Marek Schnitzer ◽

Jozef Zivcak

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

Plenary Talk

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3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽

10.3390/biomedicines9040336 ◽

2021 ◽

Vol 9 (4) ◽

pp. 336

Author(s):

Sven Pantermehl ◽

Steffen Emmert ◽

Aenne Foth ◽

Niels Grabow ◽

Said Alkildani ◽

...

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

Soft Tissue ◽

3D Printing ◽

Tissue Regeneration ◽

Research Area ◽

Modern Medicine ◽

Soft Tissue Regeneration ◽

General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

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Additive Manufacturing in Construction: a review on technologies, processes, materials and their applications of 3D and 4D printing

Material Design & Processing Communications ◽

10.1002/mdp2.253 ◽

2021 ◽

Author(s):

Gerardo Arcangelo Pacillo ◽

Giovanna Ranocchiai ◽

Federica Loccarini ◽

Mario Fagone

Keyword(s):

Additive Manufacturing ◽

4D Printing

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Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽

10.1515/epoly-2020-0046 ◽

2020 ◽

Vol 20 (1) ◽

pp. 571-599

Author(s):

Ricardo Donate ◽

Mario Monzón ◽

María Elena Alemán-Domínguez

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Additive Manufacturing ◽

Bone Regeneration ◽

Polylactic Acid ◽

State Of The Art ◽

Biological Properties ◽

Design Stage ◽

Bone Scaffolds ◽

Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

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Advances in 3D Printing for Tissue Engineering

Materials ◽

10.3390/ma14123149 ◽

2021 ◽

Vol 14 (12) ◽

pp. 3149

Author(s):

Angelika Zaszczyńska ◽

Maryla Moczulska-Heljak ◽

Arkadiusz Gradys ◽

Paweł Sajkiewicz

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

3D Printing ◽

Complex Structure ◽

Three Dimensional ◽

Computer Assisted ◽

Scaffold Fabrication ◽

Manufacturing Techniques ◽

Printing Techniques ◽

State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

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