Black Seed/Nigella/Black Cumin (Nigella sativa)

2022 ◽  
pp. 235-252
Author(s):  
Jean M. Bokelmann
Keyword(s):  
Nigella Sativa ◽  
Black Cumin ◽  
Black Seed

scholarly journals review of black seed extract as an agent in the wound healing process

2021 ◽  
Vol 1 (2) ◽  
pp. 87-96
Author(s):  
Muhammad Hakeem Mohd Zaid ◽  
Muhammad Faezuddin Hanafi ◽  
Muhammad Salahuddin Haris
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Microscopic Analysis ◽  
Seed Extract ◽  
Flowering Plant ◽  
Wound Healing Process ◽  
Black Cumin ◽  
Black Seed

Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment. Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results. Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis. Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.

scholarly journals Black cumin Potential Anticancer effect of Black Cumin seed (Nigella sativa L.) extracts as determined by Cytotoxicity test against Larvae of Artemia salina Leach using Brine Shrimp Lethality Test (BSLT)

2020 ◽  
Vol 13 (2) ◽  
pp. 25-29
Author(s):  
Rasidah ◽  
Vonna Aulianshah
Keyword(s):  
Brine Shrimp ◽  
Cytotoxic Effect ◽  
Nigella Sativa ◽  
Artemia Salina ◽  
Cytotoxicity Test ◽  
Black Cumin ◽  
Black Seed ◽  
Black Cumin Seed ◽  
Seed Extracts ◽  
Cumin Seed

Black cumin plant seed or black seed (Nigella sativa L.) is among the most commonly used spices. This plant is grown mostly for its spicy seeds. Studies have reported that black cumin seeds have high levels of antioxidant that correlates with anticancer activities. The current study aims to determine the cytotoxic effect of black seed extracts on brine shrimp larvae (Artemia salina Leach) using Brine Shrimp Lethality Test (BSLT). Black cumin seed extract was obtained through percolation method using an extraction solvent (ethanol 96%). The cytotoxicity test was performed at 0 ppm concentration (control) and 10, 50, 100, 250 and 500 ppm concentrations of black seed extracts. We use 10 Brine Shrimp larvae per tube and repeated the test three times for each test group. Our results show that ethanolic extract (90%) of black cumin seeds (Nigella sativa L.) has a strong cytotoxic effect on Artemia salina larvae with the LC50 value of 107.2 ppm.

scholarly journals Determination of chemical composition of local black seeds Nigella sativa L

2007 ◽  
Vol 4 (2) ◽  
pp. 244-247
Author(s):  
Baghdad Science Journal
Keyword(s):  
Fatty Acids ◽  
Chemical Composition ◽  
Nigella Sativa ◽  
Mineral Element ◽  
Black Cumin ◽  
Black Seed ◽  
Cobalt Nickel ◽  
Black Seeds ◽  
Seed Calcium

Chemical analysis for evaluation of Nigella sativa L. (black cumin) seeds showed a composition of Fat 39% ; Protein 28% ; Carbohydrate 21% ; Moisture 6% and Ash 4.5% . It was found that the black seed contains the following mineral element : Magnesium 0.26 gm /100gm seed ; Calcium 0.25 gm /100gm seed and Iron 25 ?g / gm /100gm seed ; zinc 4.51?g /gm /100gm seed and Copper 3.60 ?g /gm /100gm seed. The analysis also showed that mineral element I. e. ; lead ; Cobalt ; Nickel ; Chrom ; Cadmium and Aresenic are not present . It was found that the fat of the black seed contains the following fatty acids : Myristic 2.8%; Palmtic 16.6%; Stearic 0.8 % ; Oleic 13.79% ; Linoleic 64.2% and Arachidic 1.9% .

scholarly journals Nigella sativa (black seed) safety: an overview

2020 ◽  
Vol 14 (4) ◽  
pp. 127-137
Author(s):  
Habibeh Mashayekhi-Sardoo ◽  
Ramin Rezaee ◽  
Gholamreza Karimi
Keyword(s):  
Nigella Sativa ◽  
Aqueous Methanol ◽  
Black Cumin ◽  
Scientific Databases ◽  
Black Seed ◽  
Toxicological Profile ◽  
Cytotoxicity Studies ◽  
The Family ◽  
Long Term Studies

AbstractNigella sativa (commonly known as black seed or black cumin), from the family Ranunculaceae, is a plant that grows in countries bordering the Mediterranean Sea. This narrative review discusses the toxicological profile reported by short- to long-term studies that examined different extracts and oils of N. sativa seeds. Scientific databases including Web of Science, PubMed, Scopus, and Google Scholar were searched using appropriate keywords. LD50 for administered N. sativa seed fixed oil varied from 28.8 mL/kg to 3,371 mg/kg in mice, while 21 g/kg of aqueous, methanol, and chloroform extracts of N. sativa did not lead to any mortality. Subacute toxicity evaluations indicated that aqueous, methanol, and chloroform extracts of N. sativa at doses as high as 6 g/kg do not produce toxicity. Investigation of chronic toxicity found that 2 mL/kg of N. sativa fixed oil is slightly toxic. Cytotoxicity studies indicated that N. sativa chloroform and petroleum ether extracts are more cytotoxic than its other extracts. Although studies that assessed N. sativa toxicity generally introduced it as a safe medicinal herb, to draw a more definitive conclusion on its safety, more detailed studies must be conducted.

scholarly journals An Overview on Composition and Therapeutic Potentials of the Black Seed (Nigella sativa)

2021 ◽  
Vol 9 (12) ◽  
pp. 1966-1975
Author(s):  
Yusra Tafheem S
Keyword(s):  
Nigella Sativa ◽  
Herbal Medicines ◽  
Extended Period ◽  
Herbaceous Plant ◽  
Medical Systems ◽  
Active Constituent ◽  
Black Cumin ◽  
Toxicological Effects ◽  
Black Seed ◽  
Wide Range

Abstract: Nigella sativa is an annual herbaceous plant that belongs to the Ranunculaceae family and produces seeds known as black seed or black cumin. Black seed has been used in various civilization around the world for centuries to treat various ailments. It is widely used in a variety of traditional medical systems, including Unani, Ayurveda, and Siddha. Black seed is considered to be nutritionally dense, with high levels of fat, protein, dietary fibre, calcium, and iron. The seed is known to have a wide range of pharmacological properties which are supported by numerous studies. Extensive research has been carried out over decades to confirm the seed’s anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, antilipidemic, anti-cancer, gastroprotective, hepatoprotective, neuroprotective properties etc. Black seed has earned a position among the top ranked evidence-based herbal medicines due to its marvellous healing properties. Studies have revealed that the presence of thymoquinone, a major bioactive component of the seed essential oil, is responsible for the majority of its therapeutic properties. Consumption of the seeds for an extended period of time has been shown to have significant effects on lowering blood glucose levels, improving lipid profiles, and other biochemical parameters. The minor or negligible toxicological effects of black seed and its active constituent, thymoquinone, support its long-term use in traditional food and medicine. Because of their low toxicity, black seed is frequently used in food as a flavouring agent, additive in breads, and pickles. The current review summarises the composition, important pharmacological studies, dosage and toxicity of the Blackseed and its application in food industry.

scholarly journals A Review on Extraction, Characterization, and Applications of Bioactive Peptides From Pressed Black Cumin Seed Cake

2021 ◽  
Vol 8 ◽  
Author(s):  
Ahmed A. Zaky ◽  
Jae-Han Shim ◽  
A. M. Abd El-Aty
Keyword(s):  
Bioactive Peptides ◽  
Nigella Sativa ◽  
Antioxidant Properties ◽  
Economic Loss ◽  
Essential Amino Acids ◽  
Food Ingredients ◽  
Black Cumin ◽  
Seed Cake ◽  
Environmental Consequences ◽  
Black Seed

Plenty of black cumin cake was generated as a natural waste material after pressing the oil. Nigella sativa (black cumin) seeds and cakes are of precious nutritional value as they contain proteins, phenolics, essential amino acids, and bioactive compounds. Owing to their antioxidant properties, scientists and food manufacturers have extensively developed them. Notably, global awareness among consumers about the benefits of innovative food ingredients has been increased. Meanwhile, it has to be noted that vast amounts of cake by-products are not effectively utilized, which might cause economic loss and environmental consequences. This review aimed to highlight the antioxidant abilities, extraction, characterization, functional characteristics, and utilization of active peptides acquired from black seed oil cake. This overview would critically evaluate black seed cake proteins, plentiful in bioactive peptides that might be utilized as valuable additives in feed, food, pharmaceutical, and cosmetic industries. The addition of bioactive peptides to restrain the oxidation of fat-based products and preserve food safety is also addressed.

scholarly journals Nigella sativa (Kalonji): A Black Seed of Miracle

2021 ◽  
Vol 8 (4) ◽  
pp. 342-357
Author(s):  
Shifali Thakur ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Nigella Sativa ◽  
Chemical Constituents ◽  
Acne Vulgaris ◽  
World Health ◽  
Pharmacological Properties ◽  
Gulf Region ◽  
Medicinal Uses ◽  
Black Cumin ◽  
Black Seed ◽  
Wide Range

It is recommended by the World health organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa is commonly known as a Black seed, Black cumin or 'Habbatul Barakah' i.e. an annual herb possessing a wide range of medicinal uses apart from its commercial significance as a spice yielding plant. It has long been used in the folk medicine system of the Arabian Gulf region, Far East Asia, and Europe. Seeds and oils of N. Sativa are the primary medicinal source from ancient times. It is one of the most common herbal plants used worldwide and possesses various chemical constituents such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellicine, nigllimine, nigellidine, and alpha-hederin. There are more than 100 constituents isolated from the plant. These chemical compounds have many pharmacological activities such as antibacterial, antiviral, anti-inflammatory, wound healing effect and also for acne vulgaris, skin cancer, pigmentation and many other cosmeceutical properties. Much scientific research on N. sativa has been conducted over the last five decades to investigate chemical and pharmacological properties. In this review, the phytochemicals, pharmacological properties, Ayurvedic properties and folk uses of Nigella sativa are briefly explained. Keywords: Nigella sativa, Kalonji, Antinephrotic, Immunomodulary, Black cumin.

scholarly journals Efektivitas Minyak Habbatussauda (Nigella Sativa) terhadap Pertumbuhan Staphylococcus Aureus

2019 ◽  
Vol 3 (2) ◽  
pp. 14-24
Author(s):  
Nevi Sulvita
Keyword(s):  
Staphylococcus Aureus ◽  
Nigella Sativa ◽  
Disc Diffusion ◽  
Black Cumin ◽  
Black Seed

Latar belakang: Jintan hitam (Nigella sativa) atau habbatussauda,black cumin, atau pun black seed merupakan salah satu tanaman rempah yang sangat popular. Dari ekstrak biji jintan hitam yang mengandung thymoquinone, fixed oil dan turunannya ditemukan efek farmakologi yang berspektrum luas diantaranya sebagai imunopotensiasi dan anti histamine, anti diabetik, anti hipertensi, anti inflamasi dan anti mikroba. Penyakit infeksi merupakan jenis penyakit yang paling banyak diderita oleh penduduk di negara berkembang, termasuk Indonesia. Penyebab infeksi yang sering terjadi di rumah sakit salah satunya disebabkan oleh Methicillin Resistent Staphylococcus aureus. Berdasarkan hal tersebut maka perlu dilakukan penelitian untuk mengetahui efektivitas anti bakteri minyak habbatussauda pada Staphylococcus aureus yang merupakan penyebab infeksi yang memiliki prevalensi cukup tinggi di Indonesia. Penelitian ini meliputi uji efektivitas minyak habbatussauda (Nigella sativa) dalam berbagai konsentrasi dengan pertumbuhan bakteri Staphyloccoccus aureus. Tujuan: Penelitian ini bertujuan Untuk mengetahui efektivitas minyak habbatussauda terhadap pertumbuhan bakteri Staphylococcus aureus. Metode: Penelitian ini merupakan penelitian secara eksperimental laboratorium dengan metode disc diffusion. Hasil: Minyak habbatussauda ini terbukti kuat menghambat pertumbuhan bakteri Staphylococcus aureus pada konsentrasi 50% dengan daya hambat 36 mm, 40% daya hambat 29 mm, dan 30% daya hambat 26,5 mm. Kesimpulan: Minyak habbatussauda pada konsentrasi 50%, 40%, 30% berdasarkan klasifikasi Greenwood memiliki daya hambat kuat terhadap pertumbuhan bakteri Staphylococcus aureus. Pada konsentrasi 20% berdasarkan klasifikasi Greenwood memiliki daya hambat lemah terhadap pertumbuhan bakteri Staphylococcus aureus. pada konsentrasi 10% berdasarkan klasifikasi Greenwood tidak memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus. Minyak habbatussauda efektif dalam menghambat pertumbuhan Staphylococcus aureus pada konsentrasi 30%.

scholarly journals Uji Potensi Daya Hambat Ekstrak Metanol Biji Jintan Hitam (Nigella Sativa L.) Terhadap Bakteri Streptococcus

2020 ◽  
Vol 6 (1) ◽  
pp. 18-21
Author(s):  
Guntur Satrio Pratomo ◽  
Nurul Chusna ◽  
Muhammad Priyadi
Keyword(s):  
Seed Oil ◽  
Methanol Extract ◽  
Nigella Sativa ◽  
High Concentration ◽  
Black Cumin ◽  
Black Seed ◽  
Anti Cancer ◽  
Black Cumin Seed ◽  
Streptococcus Mutants ◽  
Cumin Seed

One of the plants that are often used as medicinal plants is Black Seed, Black Seed is a medicinal plant known in Indonesia by the name of black cumin. Black cumin seeds and essential oils (Nigella sativa L.) have been widely used in traditional medicine. Many studies have proven the effects of Nigella sativa extract. In various studies, black cumin seed oil shows efficacy as an anti-cancer, anti-free radical and immunomodulator, analgesic, antimicrobial, anti-inflammatory, a spasmolytic, bronchodilator, hepatoprotective, and anti-hypertensive Advanced chemical analysis found that Black Seed contains carotene that is converted into vitamin A by heart. The purpose of this study was to determine the potential inhibition of methanol extract of black cumin seeds (Nigella Sativa L.) against Streptococcus. This research uses a quantitative approach with an experimental method. This research was conducted in the Pharmacognition and Microbiology Laboratory of the Faculty of Health Sciences, Muhammadiyah University, Palangkaraya. The sample used was a sample of plant material, namely Black Cumin Seed (Nigella sativa L) which had been dried and pollinated and then extracted and then tested against bacteria. The results of testing the antibacterial activity showed that from low concentration to high concentration the diameter of the resulting inhibition showed that the activity could inhibit the bacteria streptococcus mutants. The highest inhibition at a concentration of 6% is 0.83 mm and the lowest concentration at a concentration of 3% against Streptococcus mutants.

Sign in / Sign up

Export Citation Format

Share Document